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PIK3R5 (human)

Overview PIK3R5 Regulatory subunit of the PI3K gamma complex. Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with G beta gamma proteins. Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli. Greatly activated by G gamma proteins. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis Cellular Component: membrane; cytoplasm; cytosol; nucleus Molecular Function: G-protein beta/gamma-subunit binding; 1-phosphatidylinositol-3-kinase regulator activity Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of protein kinase B signaling cascade; positive regulation of MAP kinase activity; platelet activation; phosphoinositide 3-kinase cascade; phospholipid metabolic process; phosphatidylinositol biosynthetic process; blood coagulation Reference #:  Q8WYR1 (UniProtKB) Alt. Names/Synonyms: F730038I15Rik; FOAP-2; p101; p101-PI3K; Phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit; Phosphoinositide 3-kinase regulatory subunit 5; phosphoinositide-3-kinase, regulatory subunit 5; phosphoinositide-3-kinase, regulatory subunit 5, p101; phosphoinositide-3-kinase, regulatory subunit, polypeptide p101; PI3-kinase p101 subunit; PI3-kinase regulatory subunit 5; PI3R5; PIK3R5; Protein FOAP-2; PtdIns-3-kinase p101; PtdIns-3-kinase regulatory subunit Gene Symbols: PIK3R5 Molecular weight: 97,348 Da Basal Isoelectric point: 6.3  Predict pI for various phosphorylation states CST Pathways:  Adherens Junction Dynamics  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Inhibition of Apoptosis  |  Jak/Stat/IL-6 Signaling  |  MAPK/Erk in Growth and Differentiation  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  Regulation of Actin Dynamics  |  Regulation of Microtubule Dynamics  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PIK3R5

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	4		S432-p	YKLFkSTsQLVLRRD
0	1		T114-p	STYHRFLtWPVPYCs
0	1		S121-p	tWPVPYCsICQELLT
0	1		K429-u	IRIYKLFkSTsQLVL
0	1		S440-p	QLVLRRDsRSLEGSs
0	1		S447-p	sRSLEGSsDTALPLR
0	3		S458-p	LPLRRAGsLCSPLDE
0	1		S478	SRAQRSRSLPQPKLG
0	1		S497	SWLLAPASRPQRRRP
0	6		S507-p	QRRRPFLsGDEDPKA
0	2		K782-a	LNLTEVVkRQNSKSK

	mouse
S425-p	YKLLKSTsQLVLRRD
T114	STYHCFLTWPVPYCS
S121	TWPVPYCSICREMLT
K422	NRFYKLLKSTsQLVL
S433	QLVLRRDSRSLESSV
V440	SRSLESSVDPTLPLR
S451-p	LPLRRAGsLCSPLDC
S471-p	SRAQRSRsLPQAKLT
S490-p	RWLLAPPsHHQRRRP
S500	QRRRPFLSGDEDPKA
K775	LTLTEVVKRQNPKSK

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