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Protein Page:
PIK3R5 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PIK3R5 Regulatory subunit of the PI3K gamma complex. Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with G beta gamma proteins. Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli. Greatly activated by G gamma proteins. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis
Cellular Component: membrane; cytoplasm; nucleus; cytosol
Molecular Function: G-protein beta/gamma-subunit binding; 1-phosphatidylinositol-3-kinase regulator activity
Biological Process: cell death; positive regulation of MAP kinase activity; positive regulation of protein kinase B signaling cascade; G-protein coupled receptor protein signaling pathway; platelet activation; phosphoinositide 3-kinase cascade; phospholipid metabolic process; phosphatidylinositol biosynthetic process; blood coagulation
Reference #:  Q8WYR1 (UniProtKB)
Alt. Names/Synonyms: F730038I15Rik; FOAP-2; p101; p101-PI3K; Phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit; Phosphoinositide 3-kinase regulatory subunit 5; phosphoinositide-3-kinase, regulatory subunit 5; phosphoinositide-3-kinase, regulatory subunit 5, p101; phosphoinositide-3-kinase, regulatory subunit, polypeptide p101; PI3-kinase p101 subunit; PI3-kinase regulatory subunit 5; PI3R5; PIK3R5; Protein FOAP-2; PtdIns-3-kinase p101; PtdIns-3-kinase regulatory subunit
Gene Symbols: PIK3R5
Molecular weight: 97,348 Da
Basal Isoelectric point: 6.3  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis Regulation  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-├č Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PIK3R5

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K429-u IRIYKLFkSTsQLVL
0 4 S432-p YKLFkSTsQLVLRRD
0 1 S440-p QLVLRRDsRSLEGSs
0 1 S447-p sRSLEGSsDTALPLR
0 3 S458-p LPLRRAGsLCSPLDE
0 1 S478 SRAQRSRSLPQPKLG
0 6 S507-p QRRRPFLsGDEDPKA
0 2 K782-a LNLTEVVkRQNSKSK
  mouse

 
K422 NRFYKLLKSTsQLVL
S425-p YKLLKSTsQLVLRRD
S433 QLVLRRDSRSLESSV
V440 SRSLESSVDPTLPLR
S451-p LPLRRAGsLCSPLDC
S471-p SRAQRSRsLPQAKLT
S500-p QRRRPFLsGDEDPKA
K775 LTLTEVVKRQNPKSK
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