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FGF9 (human)

Overview FGF9 Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors. Defects in FGF9 are the cause of multiple synostoses syndrome type 3 (SYNS3). Multiple synostoses syndrome is an autosomal dominant condition characterized by progressive joint fusions of the fingers, wrists, ankles and cervical spine, characteristic facies and progressive conductive deafness. Belongs to the heparin-binding growth factors family. Note: This description may include information from UniProtKB. Protein type: Cytokine Cellular Component: extracellular space; cytoplasm; extracellular region; basement membrane Molecular Function: heparin binding; growth factor activity; fibroblast growth factor receptor binding Biological Process: inner ear morphogenesis; negative regulation of Wnt receptor signaling pathway; fibroblast growth factor receptor signaling pathway; embryonic skeletal development; male gonad development; signal transduction; positive regulation of vascular endothelial growth factor receptor signaling pathway; osteoblast differentiation; cell-cell signaling; positive regulation of MAPKKK cascade; protein import into nucleus; positive regulation of cell division; male sex determination; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; insulin receptor signaling pathway; chondrocyte differentiation; positive regulation of smoothened signaling pathway; angiogenesis; embryonic gut development; regulation of timing of cell differentiation; positive regulation of epithelial cell proliferation; embryonic limb morphogenesis; positive regulation of cardiac muscle cell proliferation Reference #:  P31371 (UniProtKB) Alt. Names/Synonyms: FGF-9; FGF9; Fibroblast growth factor 9; fibroblast growth factor 9 (glia-activating factor); GAF; Glia-activating factor; HBFG-9; HBGF-9; Heparin-binding growth factor 9; MGC119914; MGC119915; SYNS3 Gene Symbols: FGF9 Molecular weight: 23,441 Da Basal Isoelectric point: 7.06  Predict pI for various phosphorylation states

Select Structure to View Below FGF9 1IHK - A=35-208 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE 600921 612961  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y163-p	VDTGRRYyVALNKDG
0	1		T176-p	DGTPREGtRtKRHQK
0	1		T178-p	TPREGtRtKRHQKFT

	mouse
Y163	VDTGRRYYVALNKDG
T176	DGTPREGTRTKRHQK
T178	TPREGTRTKRHQKFT

	rat
Y163	VDTGRRYYVALNKDG
T176	DGTPREGTRTKRHQK
T178	TPREGTRTKRHQKFT

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