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Protein Page:
FGF9 (human)

Overview
FGF9 Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors. Defects in FGF9 are the cause of multiple synostoses syndrome type 3 (SYNS3). Multiple synostoses syndrome is an autosomal dominant condition characterized by progressive joint fusions of the fingers, wrists, ankles and cervical spine, characteristic facies and progressive conductive deafness. Belongs to the heparin-binding growth factors family. Note: This description may include information from UniProtKB.
Protein type: Cytokine
Cellular Component: extracellular space; cytoplasm; extracellular region; basement membrane
Molecular Function: heparin binding; growth factor activity; fibroblast growth factor receptor binding
Biological Process: negative regulation of Wnt receptor signaling pathway; nerve growth factor receptor signaling pathway; embryonic skeletal development; negative regulation of transcription from RNA polymerase II promoter; signal transduction; positive regulation of vascular endothelial growth factor receptor signaling pathway; substantia nigra development; positive regulation of MAPKKK cascade; cell-cell signaling; protein import into nucleus; male sex determination; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; positive regulation of smoothened signaling pathway; chondrocyte differentiation; angiogenesis; regulation of timing of cell differentiation; embryonic gut development; positive regulation of cardiac muscle cell proliferation; embryonic limb morphogenesis; epidermal growth factor receptor signaling pathway; inner ear morphogenesis; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; male gonad development; osteoblast differentiation; positive regulation of cell division; insulin receptor signaling pathway; innate immune response; positive regulation of epithelial cell proliferation
Reference #:  P31371 (UniProtKB)
Alt. Names/Synonyms: FGF-9; FGF9; Fibroblast growth factor 9; fibroblast growth factor 9 (glia-activating factor); GAF; Glia-activating factor; HBFG-9; HBGF-9; Heparin-binding growth factor 9; MGC119914; MGC119915; SYNS3
Gene Symbols: FGF9
Molecular weight: 23,441 Da
Basal Isoelectric point: 7.06  Predict pI for various phosphorylation states
Select Structure to View Below

FGF9

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y163-p VDTGRRYyVALNKDG
0 1 T176-p DGTPREGtRtKRHQK
0 1 T178-p TPREGtRtKRHQKFT
  mouse

 
Y163 VDTGRRYYVALNKDG
T176 DGTPREGTRTKRHQK
T178 TPREGTRTKRHQKFT
  rat

 
Y163 VDTGRRYYVALNKDG
T176 DGTPREGTRTKRHQK
T178 TPREGTRTKRHQKFT
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