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Protein Page:
eIF3K (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
eIF3K Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Belongs to the eIF-3 subunit K family. Note: This description may include information from UniProtKB.
Protein type: Translation initiation; Translation
Cellular Component: eukaryotic translation initiation factor 3 complex; cytosol; nucleus
Molecular Function: protein binding; translation initiation factor activity; ribosome binding
Biological Process: cellular protein metabolic process; translation; translational initiation; gene expression; formation of translation preinitiation complex; regulation of translational initiation
Reference #:  Q9UBQ5 (UniProtKB)
Alt. Names/Synonyms: ARG134; eIF-3 p25; eIF-3 p28; EIF3-p28; EIF3K; EIF3S12; Eukaryotic translation initiation factor 3 subunit 12; Eukaryotic translation initiation factor 3 subunit K; eukaryotic translation initiation factor 3, subunit 12; eukaryotic translation initiation factor 3, subunit K; HSPC029; M9; MSTP001; muscle specific; Muscle-specific gene M9 protein; PLAC-24; PLAC24; PRO1474; PTD001
Gene Symbols: EIF3K
Molecular weight: 25,060 Da
Basal Isoelectric point: 4.81  Predict pI for various phosphorylation states
CST Pathways:  Translational Control
Select Structure to View Below

eIF3K

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 8 K13-ub QMRANVGkLLkGIDR
0 3 K16-ub ANVGkLLkGIDRyNP
0 1 Y21-p LLkGIDRyNPENLAt
0 1 T28-p yNPENLAtLERYVET
0 10 K38-ub RYVETQAkENAYDLE
0 2 K140-ub GFEDSVRkFICHVVG
0 2 K204-ub KPKNIVEkIDFDsVS
0 1 S209-p VEkIDFDsVSSIMAS
0 10 S217-p VSSIMASsQ______
  mouse

 
K13 QMRANVGKLLKGIDR
K16 ANVGKLLKGIDRYNP
Y21 LLKGIDRYNPENLAT
T28 YNPENLATLERYVET
K38 RYVETQAKENAYDLE
K140 GFEDSVRKFICHVVG
K204-ub KPKNIVEkIDFDSVS
S209 VEkIDFDSVSSIMAS
S217-p VSSIMASsQ______
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