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Protein Page:
CREB3L3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CREB3L3 Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE. Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Belongs to the bZIP family. ATF subfamily. Binds DNA as a dimer. Probably homodimerizes. Probably forms a heterodimer with ATF6. Interacts with ATF6. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Transcription factor
Cellular Component: endoplasmic reticulum membrane; integral to membrane; nucleus
Molecular Function: protein binding
Biological Process: transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; response to unfolded protein
Reference #:  Q68CJ9 (UniProtKB)
Alt. Names/Synonyms: cAMP responsive element binding protein 3-like 3; cAMP-responsive element-binding protein 3-like protein 3; CR3L3; CREB-H; CREB/ATF family transcription factor; CREB3L3; CREBH; Cyclic AMP-responsive element-binding protein 3-like protein 3; HYST1481; MGC126553; MGC126557; Processed cyclic AMP-responsive element-binding protein 3-like protein 3; Transcription factor CREB-H
Gene Symbols: CREB3L3
Molecular weight: 49,077 Da
Basal Isoelectric point: 4.99  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CREB3L3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S173-p PADPVDLsPRCNLTV
0 1 K225 DEKKLLAKEGItLPT
0 1 T229-p LLAKEGItLPTQLPL
0 1 S256-p RKIRNKQsAQEsRKK
0 1 S260-p NKQsAQEsRKKKKEy
0 2 Y267-p sRKKKKEyIDGLEtR
0 1 T273-p EyIDGLEtRMsACTA
0 1 S276-p DGLEtRMsACTAQNQ
0 1 K294-ac RKVLHLEkQNLSLLE
0 1 K294 RKVLHLEKQNLSLLE
  mouse

 
S168 YPEEPAGSPSRFNLT
K221-ub DEKKLLAkEGVTLPT
T225 LLAkEGVTLPTQLPL
S252 RKIRNKQSAQESRKK
S256 NKQSAQESRKKKKEY
Y263 SRKKKKEYIDGLENR
N269 EYIDGLENRMSACTA
S272 DGLENRMSACTAQNQ
K290 RKVLHLEKQNLSLLE
K290-ub RKVLHLEkQNLSLLE
  rat

 
S168 YPEEQAGSPSRFNLT
K221 DEKKLLAKEGVTLPT
T225 LLAKEGVTLPTQLPL
S252 RKIRNKQSAQESRKK
S256 NKQSAQESRKKKKEY
Y263 SRKKKKEYIDGLENR
N269 EYIDGLENRMSACTA
S272 DGLENRMSACTAQNQ
K290 RKVLHLEKQNLSLLE
K290 RKVLHLEKQNLSLLE
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