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CREB3L3 (human)

Overview CREB3L3 Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE. Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Belongs to the bZIP family. ATF subfamily. Binds DNA as a dimer. Probably homodimerizes. Probably forms a heterodimer with ATF6. Interacts with ATF6. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Transcription factor; Membrane protein, integral Cellular Component: endoplasmic reticulum membrane; cytoplasm; integral to membrane; nucleolus; nucleus Molecular Function: protein binding; sequence-specific DNA binding; transcription factor activity Biological Process: transcription, DNA-dependent; response to unfolded protein Reference #:  Q68CJ9 (UniProtKB) Alt. Names/Synonyms: cAMP responsive element binding protein 3-like 3; cAMP-responsive element-binding protein 3-like protein 3; CR3L3; CREB-H; CREB/ATF family transcription factor; CREB3L3; CREBH; Cyclic AMP-responsive element-binding protein 3-like protein 3; HYST1481; MGC126553; MGC126557; Processed cyclic AMP-responsive element-binding protein 3-like protein 3; Transcription factor CREB-H Gene Symbols: CREB3L3 Molecular weight: 49,077 Da Basal Isoelectric point: 4.99  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CREB3L3

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T229-p	LLAKEGItLPTQLPL
0	1		K225	DEKKLLAKEGItLPT
0	2		Y267-p	SRKKKKEyIDGLEtR
0	1		T273-p	EyIDGLEtRMsACTA
0	1		S276-p	DGLEtRMsACTAQNQ
0	1		K294-a	RKVLHLEkQNLSLLE
0	1		K294	RKVLHLEKQNLSLLE

	mouse
T225	LLAkEGVTLPTQLPL
K221-u	DEKKLLAkEGVTLPT
Y263	SRKKKKEYIDGLENR
N269	EYIDGLENRMSACTA
S272	DGLENRMSACTAQNQ
K290	RKVLHLEKQNLSLLE
K290-u	RKVLHLEkQNLSLLE

	rat
T225	LLAKEGVTLPTQLPL
K221	DEKKLLAKEGVTLPT
Y263	SRKKKKEYIDGLENR
N269	EYIDGLENRMSACTA
S272	DGLENRMSACTAQNQ
K290	RKVLHLEKQNLSLLE
K290	RKVLHLEKQNLSLLE

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