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Protein Page:
nAChRA2 (human)

nAChRA2 After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Defects in CHRNA2 are the cause of nocturnal frontal lobe epilepsy type 4 (ENFL4). ENFL4 is an autosomal dominant epilepsy characterized by nocturnal seizures associated with fear sensation, tongue movements, and nocturnal wandering, closely resembling nightmares and sleep walking. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 2/CHRNA2 sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: Receptor, misc.; Membrane protein, multi-pass; Membrane protein, integral; Channel, cation; Channel, ligand-gated
Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; postsynaptic membrane; plasma membrane; integral to membrane; cell junction
Molecular Function: acetylcholine receptor activity; drug binding; nicotinic acetylcholine-activated cation-selective channel activity; acetylcholine binding
Biological Process: synaptic transmission; protein heterooligomerization; ion transport; signal transduction; cation transport
Reference #:  Q15822 (UniProtKB)
Alt. Names/Synonyms: ACHA2; cholinergic receptor, nicotinic, alpha 2 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal); CHRNA2; Neuronal acetylcholine receptor subunit alpha-2
Gene Symbols: CHRNA2
Molecular weight: 59,765 Da
Basal Isoelectric point: 5.69  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease
Select Structure to View Below


Protein Structure Not Found.

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