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Protein Page:
nAChRA2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
nAChRA2 After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Defects in CHRNA2 are the cause of nocturnal frontal lobe epilepsy type 4 (ENFL4). ENFL4 is an autosomal dominant epilepsy characterized by nocturnal seizures associated with fear sensation, tongue movements, and nocturnal wandering, closely resembling nightmares and sleep walking. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 2/CHRNA2 sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, misc.; Channel, ligand-gated; Channel, cation
Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; postsynaptic membrane; integral to membrane; plasma membrane; cell junction
Molecular Function: acetylcholine receptor activity; drug binding; nicotinic acetylcholine-activated cation-selective channel activity; acetylcholine binding
Biological Process: synaptic transmission; protein heterooligomerization; ion transport; signal transduction; cation transport
Reference #:  Q15822 (UniProtKB)
Alt. Names/Synonyms: ACHA2; cholinergic receptor, nicotinic, alpha 2 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal); CHRNA2; Neuronal acetylcholine receptor subunit alpha-2
Gene Symbols: CHRNA2
Molecular weight: 59,765 Da
Basal Isoelectric point: 5.69  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease
Select Structure to View Below

nAChRA2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S81 ARPVPNTSDVVIVRF
0 1 K200 DQQNCKMKFGSWTYD
0 1 K208 FGSWTYDKAKIDLEQ
0 1 Y225-p QTVDLKDyWESGEWA
0 1 Y240-p IVNATGTyNSKKYDC
  mouse

 
S58-p ARPVPNTsDVVIVRF
K177-ac DQQNCKMkFGSWTYD
K185-ac FGSWTYDkAKIDLEQ
Y202 RTVDLKDYWESGEWA
Y217 IINATGTYNSKKYDC
  rat

 
S58 ARPVPNTSDVVIVRF
K177 DQQNCKMKFGSWTYD
K185 FGSWTYDKAKIDLEQ
Y202 RTVDLKDYWESGEWA
Y217 IINATGTYNSKKYDC
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