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Protein Page:
CD8A (human)

Overview
CD8A Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers. Shown to be expressed as heterodimer on thymocytes and as homodimer on peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Cellular Component: T cell receptor complex; integral to plasma membrane; plasma membrane; extracellular region; external side of plasma membrane
Molecular Function: protein binding; protein homodimerization activity; MHC class I protein binding; coreceptor activity; protein kinase binding
Biological Process: antigen processing and presentation; regulation of immune response; T cell activation; T cell mediated immunity; positive regulation of calcium-mediated signaling; cytotoxic T cell differentiation; immune response; defense response to virus; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P01732 (UniProtKB)
Alt. Names/Synonyms: CD8; CD8 antigen alpha polypeptide; CD8 antigen, alpha polypeptide (p32); CD8A; CD8a molecule; Leu2; Leu2 T-lymphocyte antigen; MAL; OKT8 T-cell antigen; p32; T cell co-receptor; T-cell antigen Leu2; T-cell surface glycoprotein CD8 alpha chain; T-lymphocyte differentiation antigen T8/Leu-2; T8 T-cell antigen
Gene Symbols: CD8A
Molecular weight: 25,729 Da
Basal Isoelectric point: 9.64  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CD8A

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S158 TIASQPLSLRPEACR
0 1 S224-p CPRPVVKsGDKPsLs
0 1 S229-p VKsGDKPsLsARYV_
0 1 S231-p sGDKPsLsARYV___
  CD8A iso2  
S158-p TIASQPLsLRPEACR
S187 CPRPVVKSGDKPSLS
S192 VKSGDKPSLSARYV_
S194 SGDKPSLSARYV___
  mouse

 
P172 HPTGTSQPQRPEDCR
- gap
R241 VRQEGKPRPSEKIV_
S243 QEGKPRPSEKIV___
  rat

 
P163 PPTGTPRPLRPEACR
- gap
R230 PRPLVKPRPSEKFV_
S232 PLVKPRPSEKFV___
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