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BCAT2 (human)

Overview BCAT2 Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. Homodimer. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Mitochondrial; EC 2.6.1.42; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Transferase; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis Cellular Component: mitochondrion; mitochondrial matrix; nucleus Molecular Function: branched-chain-amino-acid transaminase activity Biological Process: lactation; valine metabolic process; branched chain family amino acid catabolic process; leucine biosynthetic process; branched chain family amino acid biosynthetic process; isoleucine catabolic process Reference #:  O15382 (UniProtKB) Alt. Names/Synonyms: BCAM; BCAT(m); BCAT2; BCATM; BCT2; branched chain aminotransferase 2, mitochondrial; branched-chain amino acid aminotransferase; Branched-chain-amino-acid aminotransferase, mitochondrial; ECA40; Placental protein 18; PP18 Gene Symbols: BCAT2 Molecular weight: 44,288 Da Basal Isoelectric point: 8.88  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below BCAT2 1EKF - A/B=28-392 (human) 1EKP - A/B=28-392 (human) 1EKV - A/B=28-392 (human) 1KT8 - A/B=28-392 (human) 1KTA - A/B=28-392 (human) 2A1H - A/B=28-392 (human) 2HDK - A/B=28-392 (human) 2HG8 - A/B=28-392 (human) 2HGW - A/B=28-392 (human) 2HGX - A/B=28-392 (human) 2HHF - A/B=28-392 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 1EKF 1EKP 1EKV 1KT8 1KTA 2A1H 2HDK 2HG8 2HGW 2HGX 2HHF  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K44-a	LQLEMTQkPHKKPGP
0	1		K141	LCLPSFDKLELLECI
0	7		Y228-p	WVGGVGNykLGGNYG
0	1		K229-a	VGGVGNykLGGNYGP
0	1		K229-u	VGGVGNykLGGNYGP
0	50		K246-a	LVQQEALkRGCEQVL
0	1		K246-u	LVQQEALkRGCEQVL
0	1		K321-a	VERTITMkQLLRALE
0	1		K321-u	VERTITMkQLLRALE
0	1		K353-a	PVHRILYkDRNLHIP
0	5		K377-a	LRFQKELkEIQYGIR

	mouse
E44	LQIQMTKEPQKKPAP
K142-a	LCLPDFDkQELLECI
C229	WIGGVGDCKLGGNYG
K230	IGGVGDCKLGGNYGP
K230	IGGVGDCKLGGNYGP
K247	AVQREAQKRGCEQVL
K247	AVQREAQKRGCEQVL
K322	AERKVTMKELKRALE
K322	AERKVTMKELKRALE
E354	PVHQILYEGKQLHIP
K378	LRFQKELKAIQYGAS

	rat
E44	LQVQVTREPQKKPAP
K142	LCLPDFDKQELLECI
C229	WIGGVGDCKLGGNYG
K230	IGGVGDCKLGGNYGP
K230	IGGVGDCKLGGNYGP
K247	AVQQEAQKKGCEQVL
K247	AVQQEAQKKGCEQVL
K322	AERKVTMKELKRALE
K322	AERKVTMKELKRALE
E354	PVHQILYEGKQLHIP
K378	LRFQKELKAIQYGTS

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