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B2M
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Heterodimer of an alpha chain and a beta chain. Beta-2- microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Belongs to the beta-2-microglobulin family. Note: This description may include information from UniProtKB.
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| Protein type: Secreted; Secreted, signal peptide |
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Cellular Component: Golgi membrane; extracellular space; phagocytic vesicle membrane; endoplasmic reticulum lumen; early endosome membrane; plasma membrane; extracellular region; MHC class I protein complex; external side of plasma membrane
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Molecular Function: protein binding
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Biological Process: response to drug; regulation of immune response; viral reproduction; positive regulation of T cell mediated cytotoxicity; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; cytokine and chemokine mediated signaling pathway; T cell differentiation in the thymus; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of defense response to virus by virus; antigen processing and presentation of peptide antigen via MHC class I; response to cadmium ion; response to molecule of bacterial origin; antigen processing and presentation of exogenous peptide antigen via MHC class I; protein refolding; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
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Reference #:
P61769 (UniProtKB)
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| Alt. Names/Synonyms: B2M; B2MG; beta chain of MHC class I molecules; beta-2-microglobin; Beta-2-microglobulin; Beta-2-microglobulin form pI 5.3 |
| Gene Symbols: B2M |
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Molecular weight: 13,715 Da
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Basal Isoelectric point: 6.06
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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