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Protein Page:
B2M (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
B2M Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Heterodimer of an alpha chain and a beta chain. Beta-2- microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Belongs to the beta-2-microglobulin family. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted
Cellular Component: Golgi membrane; Golgi apparatus; extracellular space; phagocytic vesicle membrane; membrane; early endosome membrane; endoplasmic reticulum lumen; cytoplasm; extracellular region; plasma membrane; MHC class I protein complex; external side of plasma membrane
Molecular Function: identical protein binding; protein binding
Biological Process: response to drug; regulation of immune response; viral reproduction; positive regulation of T cell mediated cytotoxicity; cytokine and chemokine mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; T cell differentiation in the thymus; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of defense response to virus by virus; retinal homeostasis; antigen processing and presentation of peptide antigen via MHC class I; response to cadmium ion; response to molecule of bacterial origin; antigen processing and presentation of exogenous peptide antigen via MHC class I; innate immune response; protein refolding; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
Reference #:  P61769 (UniProtKB)
Alt. Names/Synonyms: B2M; B2MG; beta chain of MHC class I molecules; beta-2-microglobin; Beta-2-microglobulin; Beta-2-microglobulin form pI 5.3
Gene Symbols: B2M
Molecular weight: 13,715 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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B2M

Protein Structure Not Found.


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1A1M
1A1N
1A1O
1A6Z
1A9B
1A9E
1AGB
1AGC
1AGD
1AGE
1AGF
1C16
1CE6
1CG9
1E27
1E28
1EXU
1HSA
1HSB
1JGD
1JGE
1JNJ
1K5N
1LDS
1M05
1M6O
1MI5
1N2R
1ONQ
1PY4
1Q94
1QLF
1QQD
1QVO
1R3H
1SYV
1TMC
1UXS
1UXW
1VGK
1X7Q
1XH3
1XR8
1XZ0
1YDP
1YPZ
1ZHK
1ZHL
1ZS8
1ZSD
1ZT4
1ZVS
2A83
2AK4
2AXF
2AXG
2BSR
2BSS
2BST
2BVO
2BVP
2BVQ
2CII
2CIK
2D4D
2D4F
2E8D
2F74
2F8O
2FYY
2FZ3
2H26
2H6P
2HJK
2HJL
2HLA
2HN7
2NW3
2NX5
2PO6
2RFX
2VB5
2VLJ
2VLK
2VLL
2VLR
2X4N
2X4O
2X4P
2X4Q
2X4R
2X4S
2X4T
2X4U
2X70
2X89
2XKS
2XKU
2XPG
2YPK
2YPL
2YXF
2Z9T
3AM8
3B3I
3B6S
3BGM
3BH8
3BH9
3BHB
3BO8
3BP4
3BP7
3BVN
3BW9
3BWA
3BXN
3BZE
3BZF
3C9N
3CDG
3CII
3CIQ
3CZF
3D18
3D25
3D2U
3D39
3D3V
3DBX
3DHJ
3DHM
3DTX
3DX6
3DX7
3DX8
3DXA
3EKC
3FFC
3FQN
3FQR
3FQT
3FQU
3FQW
3FQX
3FT2
3FT3
3FT4
3GIV
3GJF
3GSN
3GSO
3GSQ
3GSR
3GSU
3GSV
3GSW
3GSX
3H7B
3H9H
3H9S
3HAE
3HCV
3HG1
3HPJ
3HUJ
3I6G
3I6K
3I6L
3IB4
3IXA
3JTS
3KLA
3KPL
3KPM
3KPN
3KPO
3KPP
3KPQ
3KPR
3KPS
3KWW
3KXF
3KYN
3KYO
3L3D
3L3G
3L3I
3L3J
3L3K
3LKN
3LKO
3LKP
3LKQ
3LKR
3LKS
3LN4
3LN5
3LOW
3LOZ
3LV3
3M17
3M1B
3MGO
3MGT
3MR9
3MRB
3MRC
3MRD
3MRE
3MRF
3MRG
3MRH
3MRI
3MRJ
3MRK
3MRL
3MRM
3MRN
3MRO
3MRP
3MRQ
3MRR
3MV7
3MV8
3MV9
3MYJ
3MYZ
3MZT
3NA4
3NFN
3O3A
3O3B
3O3D
3O3E
3O4L
3OV6
3OX8
3OXR
3OXS
3PWJ
3PWL
3PWN
3PWP
3QDA
3QDG
3QDJ
3QDM
3QEQ
3QFD
3QFJ
3QZW
3REW
3RL1
3RL2
3RWJ
3S6C
3SDX
3SJV
3SKM
3SKO
3SPV
3T8X
3TID
3TIE
3TLR
3TM6
3TO2
3TZV
3U0P
3UPR
3UTQ
3UTS
3UTT
3V5D
3V5H
3V5K
3VCL
3VFM
3VFN
3VFO
3VFP
3VFR
3VFS
3VFT
3VFU
3VFV
3VFW
3VH8
3VRI
3VRJ
3VWJ
3VWK
3VXM
3VXN
3VXO
3VXP
3VXR
3VXS
3VXU
3W0W
3W39
3WL9
3WLB
3WUW
4BEO
4E5X
4EN3
4EUP
4EUQ
4F7M
4F7P
4F7T
4FTV
4FXL
4G8G
4G8I
4G9D
4G9F
4GKS
4GUP
4HKJ
4HWZ
4HX1
4I48
4I4W
4JFD
4JFE
4JFF
4JFO
4JFP
4JFQ
4JQV
4JQX
4JRX
4JRY
4K71
4K7F
4KDT
4L29
4L3C
4L3E
4L4T
4L4V
4LCW
4LCY
4LHU
4LNR
4MJI
4MNQ
4N0F
4N0U
4N8V
4NQC
4NQD
4NQE
4NQV
4NQX
4NT6
4O2C
4O2E
4O2F
4PJ5
4PJ7
4PJ8
4PJ9
4PJA
4PJB
4PJC
4PJD
4PJE
4PJF
4PJG
4PJH
4PJI
4PJX
4PR5
4PRA
4PRB
4PRD
4PRE
4PRH
4PRI
4PRN
4PRP
4QRT
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S4-p ____MSRsVALAVLA
0 1 S14-p LAVLALLsLSGLEAI
0 1 T24-p GLEAIQRtPKIQVys
0 4 Y30-p RtPKIQVysRHPAEN
0 1 S31-p tPKIQVysRHPAENG
0 4 K61-ub DIEVDLLkNGERIEk
0 2 K68-ub kNGERIEkVEHSDLS
0 1 T106-ga ACRVNHVtLSQPkIV
0 1 K111-ub HVtLSQPkIVkWDRD
0 2 K114-ub LSQPkIVkWDRDM__
  mouse

 
S4 ____MARSVTLVFLV
S14 LVFLVLVSLTGLYAI
T24 GLYAIQKTPQIQVyS
Y30-p KTPQIQVySRHPPEN
S31 TPQIQVySRHPPENG
K61 HIEIQMLKNGKKIPK
K68 KNGKKIPKVEMSDMS
S106 ACRVKHASMAEPKTV
K111 HASMAEPKTVYWDRD
Y114 MAEPKTVYWDRDM__
  rat

 
S4 ____MARSVTVIFLV
S14 VIFLVLVSLAVVLAI
T24 VVLAIQKTPQIQVYS
Y30 KTPQIQVYSRHPPEN
S31 TPQIQVYSRHPPENG
K61 QIEIELLKNGKKIPN
N68 KNGKKIPNIEMSDLS
T106 ACRVKHVTLKEPKTV
K111 HVTLKEPKTVTWDRD
T114 LKEPKTVTWDRDM__
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