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Protein Page:
ASF1B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ASF1B Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for spermatogenesis. Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4. Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex. Interacts with HAT1, NASP, TAF1, TLK1 and TLK2. Highly expressed in testis and at lower levels in colon, small intestine and thymus. Belongs to the ASF1 family. Note: This description may include information from UniProtKB.
Cellular Component: protein complex; nuclear chromatin; nucleolus; nucleus
Molecular Function: protein binding; histone binding
Biological Process: regulation of transcription, DNA-dependent; DNA replication-independent nucleosome assembly; transcription, DNA-dependent; multicellular organismal development; spermatogenesis; chromatin modification; cell differentiation; DNA replication-dependent nucleosome assembly
Reference #:  Q9NVP2 (UniProtKB)
Alt. Names/Synonyms: Anti-silencing function protein 1 homolog B; ASF1 anti-silencing function 1 homolog B (S. cerevisiae); ASF1B; CCG1-interacting factor A-II; CIA-II; FLJ10604; hAsf1; hAsf1b; hCIA-II; Histone chaperone ASF1B
Gene Symbols: ASF1B
Molecular weight: 22,434 Da
Basal Isoelectric point: 4.46  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ASF1B

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y111-p QEFIRVGyYVNNEyL
0 3 Y117-p GyYVNNEyLNPELRE
0 4 K129-ub LRENPPMkPDFSQLQ
0 3 T179-p CGLPLNCtPIKGLGL
1 11 S198-p PGLLPENsMDCI___
  mouse

 
Y111 QEFIRVGYYVNNEYP
Y117 GYYVNNEYPDPELRE
K129 LRENPPPKPDFSQLQ
T179 FSLSLSCTPVKSLGL
S198-p PGLLPENsMDCI___
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