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ASF1B (human)

Overview ASF1B Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for spermatogenesis. Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4. Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex. Interacts with HAT1, NASP, TAF1, TLK1 and TLK2. Highly expressed in testis and at lower levels in colon, small intestine and thymus. Belongs to the ASF1 family. Note: This description may include information from UniProtKB. Cellular Component: nucleus; chromatin Molecular Function: histone binding Biological Process: nucleosome assembly; regulation of transcription, DNA-dependent; transcription, DNA-dependent; multicellular organismal development; spermatogenesis; chromatin modification; cell differentiation Reference #:  Q9NVP2 (UniProtKB) Alt. Names/Synonyms: Anti-silencing function protein 1 homolog B; ASF1 anti-silencing function 1 homolog B (S. cerevisiae); ASF1B; CCG1-interacting factor A-II; CIA-II; FLJ10604; hAsf1; hAsf1b; hCIA-II; Histone chaperone ASF1B Gene Symbols: ASF1B Molecular weight: 22,434 Da Basal Isoelectric point: 4.46  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ASF1B

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		Y111-p	QEFIRVGyYVNNEyL
0	3		Y117-p	GyYVNNEyLNPELRE
0	4		K129-u	LRENPPMkPDFSQLQ
0	2		T179-p	CGLPLNCtPIKGLGL
1	11		S198-p	PGLLPENsMDCI___

	mouse
Y111	QEFIRVGYYVNNEYP
Y117	GYYVNNEYPDPELRE
K129	LRENPPPKPDFSQLQ
T179	FSLSLSCTPVKSLGL
S198-p	PGLLPENsMDCI___

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