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Protein Page:
ADAMTS10 (human)

Overview
ADAMTS10 Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues. Defects in ADAMTS10 are the cause of Weill-Marchesani syndrome 1 (WMS1). WMS1 is a rare connective tissue disorder characterized by short stature, brachydactyly, joint stiffness, and eye abnormalities including microspherophakia, ectopia lentis, severe myopia and glaucoma. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; Protease; EC 3.4.24.-
Cellular Component: extracellular matrix; microfibril
Molecular Function: protein binding; zinc ion binding; metalloendopeptidase activity
Biological Process: proteolysis
Reference #:  Q9H324 (UniProtKB)
Alt. Names/Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 10; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10; ADAM metallopeptidase with thrombospondin type 1 motif, 10; ADAM-TS 10; ADAM-TS10; ADAMTS-10; ADAMTS10; ATS10; WMS; zinc metalloendopeptidase
Gene Symbols: ADAMTS10
Molecular weight: 120,874 Da
Basal Isoelectric point: 8.34  Predict pI for various phosphorylation states
Select Structure to View Below

ADAMTS10

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S34 RSQDEFLSSLESYEI
0 1 S35 SQDEFLSSLESYEIA
0 1 Y39 FLSSLESYEIAFPTR
0 1 T68-p PRRQRRGtGAtAEsR
0 1 T71-p QRRGtGAtAEsRLFY
0 2 S74-p GtGAtAEsRLFYKVA
0 1 Y240-p RSVSRERyVETLVVA
0 1 Y254-p ADKMMVAyHGRRDVE
0 1 S278-p VAKLFQDssLGstVN
0 1 S279-p AKLFQDssLGstVNI
0 1 S282-p FQDssLGstVNILVT
0 1 T283-p QDssLGstVNILVTR
0 1 T428 AAHITMKTNPFVWSS
0 1 S870 PHYCSAHSKLPKRQR
0 1 T1050-p EALRPPTtQQCEAKC
  mouse

 
S34 RSQDELLSSLESYEI
S35 SQDELLSSLESYEIA
Y39 LLSSLESYEIAFPTR
A68 FRRQRRGAGATTESR
T71 QRRGAGATTESRLFY
S74 GAGATTESRLFYKVA
Y240 RSVSRERYVETLVVA
Y254 ADKMMVAYHGRRDVE
S278 VAKLFQDSSLGNIVN
S279 AKLFQDSSLGNIVNI
N282 FQDSSLGNIVNILVT
I283 QDSSLGNIVNILVTR
T428-p AAHITMKtNPFVWSS
S870-p PHYCSGHsKLPKRQR
M1050 EALRPSTMQQCEAKC
  rat

 
S34-p RSQDELLssLESyEI
S35-p SQDELLssLESyEIA
Y39-p LLssLESyEIAFPTR
V68 LRRQRRGVGAAAESR
A71 QRRGVGAAAESRLFY
S74 GVGAAAESRLFYKVT
Y240 RSVSRERYVETLVVA
Y254 ADKMMVAYHGRRDVE
S278 VAKLFQDSSLGNIVN
S279 AKLFQDSSLGNIVNI
N282 FQDSSLGNIVNILVT
I283 QDSSLGNIVNILVTR
T428 AAHITMKTNPFVWSS
- gap
- gap
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