May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis. Homodimer and heterodimer with BCAP29. Binds CASP8 (isoform 9) as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1. Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1 and non-muscle myosin II. Interacts with PTPLB. Ubiquitous. Belongs to the BCAP29/BCAP31 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: endoplasmic reticulum membrane; clathrin-coated vesicle; mitochondrion; integral to plasma membrane; cell; endoplasmic reticulum; integral to membrane; lipid particle; cytosol; Golgi membrane; membrane; cytoplasm; plasma membrane; intracellular
Molecular Function: protein binding; MHC class I protein binding; protein complex binding
Biological Process: vesicle-mediated transport; intracellular protein transport; ER to Golgi vesicle-mediated transport; protein transport; elevation of cytosolic calcium ion concentration; transport; apoptosis; reduction of endoplasmic reticulum calcium ion concentration; positive regulation of caspase activity; immune response; elevation of mitochondrial calcium ion concentration
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.