May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: Golgi membrane; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; integral to plasma membrane; endoplasmic reticulum; lipid particle; cytosol
Molecular Function: protein binding
Biological Process: vesicle-mediated transport; intracellular protein transport; elevation of cytosolic calcium ion concentration; antigen processing and presentation of peptide antigen via MHC class I; apoptosis; reduction of endoplasmic reticulum calcium ion concentration; positive regulation of caspase activity; spermatogenesis; immune response; cell structure disassembly during apoptosis; elevation of mitochondrial calcium ion concentration
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.