|
A6
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. Interacts with G-actin; ADP-actin form and capping protein (CP). May also be able to interact with TWF2 and phosphoinositides, PI(4,5)P2. When bound to PI(4,5)P2, it is down- regulated. Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver. Belongs to the actin-binding proteins ADF family. Twinfilin subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
|
| Protein type: Motility/polarity/chemotaxis |
|
Cellular Component: myofibril; perinuclear region of cytoplasm; cytoplasm; intercellular junction; actin cytoskeleton; filopodium
|
|
Molecular Function: actin monomer binding; phosphatidylinositol-4,5-bisphosphate binding; protein-tyrosine kinase activity; ATP binding
|
|
Biological Process: sequestering of actin monomers; negative regulation of actin filament polymerization; regulation of actin phosphorylation; barbed-end actin filament capping
|
|
Reference #:
Q12792 (UniProtKB)
|
| Alt. Names/Synonyms: A6; A6 protein tyrosine kinase; MGC23788; MGC41876; Protein A6; Protein tyrosine kinase 9; PTK9; PTK9 protein tyrosine kinase 9; TWF1; twinfilin, actin-binding protein, homolog 1 (Drosophila); Twinfilin-1 |
| Gene Symbols: TWF1 |
|
Molecular weight: 40,283 Da
|
|
Basal Isoelectric point: 6.48
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
|
