Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface. Interacts with GLUT4. Ubiquitous. Highly expressed in testis, heart, skeletal muscle and pancreas. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, peripheral; Vesicle protein
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: internal side of plasma membrane; extrinsic to membrane; perinuclear region of cytoplasm; endomembrane system; vesicle membrane; cytosol; nucleus
Molecular Function: protein binding
Biological Process: intracellular protein transport; regulation of glucose import; glucose homeostasis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.