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ASPSCR1 (human)

Overview ASPSCR1 Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface. Interacts with GLUT4. Ubiquitous. Highly expressed in testis, heart, skeletal muscle and pancreas. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Cellular Component: internal side of plasma membrane; extrinsic to membrane; perinuclear region of cytoplasm; vesicle membrane; cytosol Molecular Function: protein binding Biological Process: intracellular protein transport; regulation of glucose import; glucose homeostasis Reference #:  Q9BZE9 (UniProtKB) Alt. Names/Synonyms: Alveolar soft part sarcoma chromosomal region candidate gene 1 protein; alveolar soft part sarcoma chromosome region, candidate 1; Alveolar soft part sarcoma locus; ASPC1; ASPCR1; ASPL; ASPS; ASPSCR1; FLJ45380; RCC17; renal cell carcinoma gene on chromosome 17; renal cell carcinoma, papillary, 17; Renal papillary cell carcinoma protein 17; Tether containing UBX domain for GLUT4; TUG; UBX domain protein 9; UBX domain-containing protein 9; UBXD9; UBXN9 Gene Symbols: ASPSCR1 Molecular weight: 60,183 Da Basal Isoelectric point: 6.23  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ASPSCR1

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  DISEASE 605074 606236 606243  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		T23	APNGRRHTVKVTPST
0	1		K75-u	ANLPNNAkLEMVPAS
0	1		T167	GLTGGSATIRFVMKC
0	6		S184	PVGKTPGSLGSSASA
0	1		S187	KTPGSLGSSASAGQA
0	2		S190	GSLGSSASAGQAAAS
0	1		P258	RLGGPPGPTRPLtss
0	1		T263-p	PGPTRPLtsssAKLP
0	6		S264-p	GPTRPLtsssAKLPK
0	1		S265-p	PTRPLtsssAKLPKS
0	1		S266-p	TRPLtsssAKLPKSL
0	1		K281-a	SSPGGPSkPKKSKSG
0	1		K374	EEAPLVTKAFREAQI
0	1		-	gap
0	2		A498	ARYMSRAAGsPsPLP
0	6		S500-p	YMSRAAGsPsPLPAP
0	4		S502-p	SRAAGsPsPLPAPDP
0	1		P511	LPAPDPAPKSEPAAE
0	1		S513	APDPAPKSEPAAEEG
0	9		K552-a	WLKLPASkR______

	ASPSCR1 iso2
T23	APNGRRHTVKVTPST
K75	ANLPNNAKLEMVPAS
T167	GLTGGSATIRFVMKC
S184	PVGKTPGSLGSSASA
S187	KTPGSLGSSASAGQA
S190	GSLGSSASAGQAAAS
P258	RLGGPPGPTRPLTSS
T263	PGPTRPLTSSSAKLP
S264	GPTRPLTSSSAKLPK
S265	PTRPLTSSSAKLPKS
S266	TRPLTSSSAKLPKSL
K281	SSPGGPSKPKKSKSG
K374	EEAPLVTKAFREAQI
S499-p	RLLFWGPsRGRASPS
A592	ARYMSRAAGSPSPLP
S594	YMSRAAGSPSPLPAP
S596	SRAAGSPSPLPAPDP
P605	LPAPDPAPKSEPAAE
S607	APDPAPKSEPAAEEG
K646	WLKLPASKR______

	mouse
T23	APNGRRHTVKVTPST
K75	ANLPNNAKLEMVPVS
T167-p	GLTGGSAtIRFVIKQ
S193-p	VRSKAPGsPVsSLsA
S196-p	KAPGsPVsSLsADQA
S199-p	GsPVsSLsADQASSS
S273-p	RLGGPSAsLRPLtsP
T278-p	SAsLRPLtsPSANSS
S279-p	AsLRPLtsPSANSSK
P280	sLRPLtsPSANSSKS
S281	LRPLtsPSANSSKSF
K296	SGPGGPSKPKKPKPG
K370-u	EEAPLVTkAFREAQM
-	gap
S494-p	ARCMSRAsGsPPLLP
S496-p	CMSRAsGsPPLLPAP
P498	SRAsGsPPLLPAPDP
S507-p	LPAPDPVsLEsEPIA
S510-p	PDPVsLEsEPIAEDG
K549	WLKLPASKR______

	rat
T23-p	APNGRRHtVKVTPST
K75	ANLPNNAKLEMVPAS
T167	GLTGGSATIRFVIKQ
S193-p	VRSKPPGsPVSSMSA
S196	KPPGsPVSSMSADQA
S199	GsPVSSMSADQASSS
S274	RLGGPSVSLRSLTSP
T279	SVSLRSLTSPAAKSS
S280	VSLRSLTSPAAKSST
P281	SLRSLTSPAAKSSTS
A282	LRSLTSPAAKSSTSF
K297	SGPGGPSKPKKSKPG
K371	EEAPLVTKAFREAQM
-	gap
A474	ARCMSRAAGSPSLLP
S476	CMSRAAGSPSLLPAP
S478	SRAAGSPSLLPAPDP
S487	LPAPDPVSLDSEPIA
S490	PDPVSLDSEPIAEEG
K529	WLKLPASKR______

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