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SHOT1 (human)

Overview SHOT1 Involved in the generation of internal asymmetric signals required for neuronal polarization. Acts upstream of PI3K (phosphoinositide 3-kinase), by being required for spatially localized PI3K activity. Accumulates asymmetrically in a single neurite before polarization, leading to axon induction for polarization, its absence from the nascent axon's siblings by competition preventing the formation of surplus axons. Interacts with RUFY3. Belongs to the shootin family. 7 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Unknown function Cellular Component: axon; cytosol Molecular Function: kinase binding Biological Process: axon guidance Reference #:  A0MZ66 (UniProtKB) Alt. Names/Synonyms: DKFZp686A0439; KIAA1598; MGC40476; Shootin-1; SHOOTIN1; SHOT1 Gene Symbols: KIAA1598 Molecular weight: 71,640 Da Basal Isoelectric point: 5.27  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SHOT1

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S3	_____MNSSDEEKQL
0	1		S4	____MNSSDEEKQLQ
0	1		K17-u	LQLITSLkEQAIGEy
0	7		Y24-p	kEQAIGEyEDLRAEN
0	1		K35-a	RAENQKTkEkCDKIR
0	1		K37-a	ENQKTkEkCDKIRQE
0	1		S59	LEEFQKISHMVIEEV
0	1		K89	SAEALATKLNKENKT
1	1		S101-p	NKTLKRIsMLyMAKL
0	2		Y104-p	LKRIsMLyMAKLGPD
0	1		Y214-p	SMLAVEEyEEMQVNL
0	1		K244	EMFIEQNKLKRQsHL
1	8		S249-p	QNKLKRQsHLLLQSS
0	1		S375	NPIRSLMSMIRKRSH
0	1		S381	MSMIRKRSHPsGSGA
0	1		S384-p	IRKRSHPsGSGAKKE
0	1		K392	GSGAKKEKATQPETT
0	4		K406-a	TEEVTDLkRQAVEEM
0	1		K406-u	TEEVTDLkRQAVEEM
0	1		S459	ILGTLNKSTSSRsLk
0	2		S464-p	NKSTSSRsLksLDPE
0	1		K466-u	STSSRsLksLDPENS
0	2		S467-p	TSSRsLksLDPENSE
0	1		S473	ksLDPENSETELERI
0	1		K485-u	ERILRRRkVtAEADs
0	10		T487-p	ILRRRkVtAEADsSs
0	1		S492-p	kVtAEADsSsPtGIL
0	5		S494-p	tAEADsSsPtGILAT
0	2		T496-p	EADsSsPtGILATSE
0	1		S504	GILATSESKsMPVLG
0	13		S506-p	LATSESKsMPVLGSV
0	2		S515-p	PVLGSVSsVTKTALN
0	1		K524-u	TKTALNKkTLEAEFN
0	2		S532-p	TLEAEFNsPsPPtPE
0	1		S534-p	EAEFNsPsPPtPEPG
0	3		T537-p	FNsPsPPtPEPGEGP
0	1		K616-u	GEIQPENkEDSIENV

	mouse
S3-p	_____MNssDEEKQL
S4-p	____MNssDEEKQLQ
K17	LQLITSLKEQAIGEy
Y24-p	KEQAIGEyEDLRAEN
K35	RAENQKTKEKCDKIR
K37	ENQKTKEKCDKIRQE
S59-p	LEEFQKIsHMVIEEV
K89-u	SAEALATkLNKENKT
S101-p	NKTLKRIsMLYMAKL
Y104	LKRIsMLYMAKLGPD
Y214	SMLAVEEYEELQVNL
K244-u	EMFIEQNkLKRQsHL
S249-p	QNkLKRQsHLLLQSS
S375-p	NPIRSLMsMIRKRsH
S381-p	MsMIRKRsHPSGNSA
S384	IRKRsHPSGNSAKKE
K392-m1	GNSAKKEkTTQPETA
K406	AEEVTDLKRQAVEEM
K406	AEEVTDLKRQAVEEM
S459-p	ILGTLNKsTSSRsLK
S464-p	NKsTSSRsLKsLGPE
K466	sTSSRsLKsLGPENs
S467-p	TSSRsLKsLGPENsE
S473-p	KsLGPENsETELERI
K485	ERILRRRKLtAEADS
T487-p	ILRRRKLtAEADSSs
S492	KLtAEADSSsPTGIL
S494-p	tAEADSSsPTGILAT
T496	EADSSsPTGILATSE
S504-p	GILATSEsKsMPVLG
S506-p	LATSEsKsMPVLGSV
S515	PVLGSVSSVTKSALN
K524	TKSALNKKTLEAEFN
N532	TLEAEFNNPCPLTPE
C534	EAEFNNPCPLTPEPG
T537	FNNPCPLTPEPGEGP
K616	GETQPEYKEDSGGKT

	rat
S3	_____MNSSDEEKQL
S4	____MNSSDEEKQLQ
K17	LQLITSLKEQAIGEY
Y24	KEQAIGEYEDLRAEN
K35	RAENQKTKETCDKIR
T37	ENQKTKETCDKIRQE
S59	LEEFQKISHMVIEEV
K89	SAEALATKLNKENKT
S101-p	NKTLKRIsMLYMAKL
Y104	LKRIsMLYMAKLGPD
Y214	SVLAVEEYEELQVNL
K244	EMFIEQNKLKRQsHL
S249-p	QNKLKRQsHLLLQSS
S375	NPIRSLMSMIRKRSH
S381	MSMIRKRSHPSGGST
S384	IRKRSHPSGGSTKKE
K392	GGSTKKEKATQPETA
K406	AEEVTDLKRQAVEEM
K406	AEEVTDLKRQAVEEM
S459	ILGTLNKSTSSRSLK
S464	NKSTSSRSLKSLGPE
K466	STSSRSLKSLGPENS
S467	TSSRSLKSLGPENSE
S473	KSLGPENSETELERI
K485	ERILRRRKLTAEADS
T487	ILRRRKLTAEADSSS
S492	KLTAEADSSSPTGIL
S494	TAEADSSSPTGILAT
T496	EADSSSPTGILATSE
S504	GILATSESKSMPVLG
S506	LATSESKSMPVLGSV
S515	PVLGSVSSVTKSALN
K524	TKSALNKKTLEAEFN
N532	TLEAEFNNPCPLTPE
C534	EAEFNNPCPLTPEPG
T537	FNNPCPLTPEPGEGP
K617	GETQPEFKEDSSGGK

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