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Protein Page:
SHOT1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SHOT1 Involved in the generation of internal asymmetric signals required for neuronal polarization. Acts upstream of PI3K (phosphoinositide 3-kinase), by being required for spatially localized PI3K activity. Accumulates asymmetrically in a single neurite before polarization, leading to axon induction for polarization, its absence from the nascent axon's siblings by competition preventing the formation of surplus axons. Interacts with RUFY3. Belongs to the shootin family. 7 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Cellular Component: axon
Molecular Function: kinase binding
Biological Process: axon guidance
Reference #:  A0MZ66 (UniProtKB)
Alt. Names/Synonyms: DKFZp686A0439; KIAA1598; MGC40476; Shootin-1; SHOOTIN1; SHOT1
Gene Symbols: KIAA1598
Molecular weight: 71,640 Da
Basal Isoelectric point: 5.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SHOT1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S3 _____MNSsDEEKQL
0 2 S4-p ____MNSsDEEKQLQ
0 1 S15-p KQLQLITsLkEQAIG
0 1 K17-ub LQLITsLkEQAIGEy
0 9 Y24-p kEQAIGEyEDLRAEN
0 1 K35-ac RAENQKTkEkCDKIR
0 1 K37-ac ENQKTkEkCDKIRQE
0 1 S59 LEEFQKISHMVIEEV
0 1 K89 SAEALATKLNKENKT
1 1 S101-p NKTLKRIsMLyMAKL
0 4 Y104-p LKRIsMLyMAKLGPD
0 1 Y214-p SMLAVEEyEEMQVNL
0 1 K244 EMFIEQNKLKRQsHL
1 14 S249-p QNKLKRQsHLLLQSS
0 4 S375-p NPIRSLMsMIRKRSH
0 1 S381 MsMIRKRSHPsGSGA
0 1 S384-p IRKRSHPsGSGAKKE
0 1 K392 GSGAKKEKATQPETT
0 4 K406-ac TEEVTDLkRQAVEEM
0 1 K406-ub TEEVTDLkRQAVEEM
0 2 S459-p ILGTLNKsTSSRsLk
0 3 S464-p NKsTSSRsLksLDPE
0 1 K466-ub sTSSRsLksLDPENs
0 4 S467-p TSSRsLksLDPENsE
0 4 S473-p ksLDPENsETELERI
0 1 K485-ub ERILRRRkVtAEADs
0 14 T487-p ILRRRkVtAEADsss
0 2 S492-p kVtAEADsssPtGIL
0 1 S493-p VtAEADsssPtGILA
0 10 S494-p tAEADsssPtGILAT
0 4 T496-p EADsssPtGILATSE
0 1 S504 GILATSESKsMPVLG
0 20 S506-p LATSESKsMPVLGSV
0 5 S515-p PVLGSVSsVTKTALN
0 1 K524-ub TKTALNKkTLEAEFN
0 5 S532-p TLEAEFNsPsPPtPE
0 4 S534-p EAEFNsPsPPtPEPG
0 7 T537-p FNsPsPPtPEPGEGP
0 1 K616-ub GEIQPENkEDsIENV
0 2 S619-p QPENkEDsIENVRET
  mouse

 
S3-p _____MNssDEEKQL
S4-p ____MNssDEEKQLQ
S15 KQLQLITSLKEQAIG
K17 LQLITSLKEQAIGEy
Y24-p KEQAIGEyEDLRAEN
K35 RAENQKTKEKCDKIR
K37 ENQKTKEKCDKIRQE
S59-p LEEFQKIsHMVIEEV
K89-ub SAEALATkLNKENKT
S101-p NKTLKRIsMLYMAKL
Y104 LKRIsMLYMAKLGPD
Y214 SMLAVEEYEELQVNL
K244-ub EMFIEQNkLKRQsHL
S249-p QNkLKRQsHLLLQSS
S375-p NPIRSLMsMIRKRsH
S381-p MsMIRKRsHPSGNSA
S384 IRKRsHPSGNSAKKE
K392-m1 GNSAKKEkTTQPETA
K406 AEEVTDLKRQAVEEM
K406 AEEVTDLKRQAVEEM
S459-p ILGTLNKsTSSRsLK
S464-p NKsTSSRsLKsLGPE
K466 sTSSRsLKsLGPENs
S467-p TSSRsLKsLGPENsE
S473-p KsLGPENsETELERI
K485 ERILRRRKLtAEADs
T487-p ILRRRKLtAEADsSs
S492-p KLtAEADsSsPtGIL
S493 LtAEADsSsPtGILA
S494-p tAEADsSsPtGILAT
T496-p EADsSsPtGILATSE
S504-p GILATSEsKsMPVLG
S506-p LATSEsKsMPVLGSV
S515 PVLGSVSSVTKSALN
K524 TKSALNKKTLEAEFN
N532 TLEAEFNNPCPLtPE
C534 EAEFNNPCPLtPEPG
T537-p FNNPCPLtPEPGEGP
K616 GETQPEYKEDSGGKT
S619 QPEYKEDSGGKTGET
  rat

 
S3 _____MNSSDEEKQL
S4 ____MNSSDEEKQLQ
S15 KQLQLITSLKEQAIG
K17 LQLITSLKEQAIGEY
Y24 KEQAIGEYEDLRAEN
K35 RAENQKTKETCDKIR
T37 ENQKTKETCDKIRQE
S59 LEEFQKISHMVIEEV
K89 SAEALATKLNKENKT
S101-p NKTLKRIsMLYMAKL
Y104 LKRIsMLYMAKLGPD
Y214 SVLAVEEYEELQVNL
K244 EMFIEQNKLKRQsHL
S249-p QNKLKRQsHLLLQSS
S375 NPIRSLMSMIRKRSH
S381 MSMIRKRSHPSGGST
S384 IRKRSHPSGGSTKKE
K392 GGSTKKEKATQPETA
K406 AEEVTDLKRQAVEEM
K406 AEEVTDLKRQAVEEM
S459 ILGTLNKSTSSRSLK
S464 NKSTSSRSLKSLGPE
K466 STSSRSLKSLGPENS
S467 TSSRSLKSLGPENSE
S473 KSLGPENSETELERI
K485 ERILRRRKLTAEADS
T487 ILRRRKLTAEADSSS
S492 KLTAEADSSSPTGIL
S493 LTAEADSSSPTGILA
S494 TAEADSSSPTGILAT
T496 EADSSSPTGILATSE
S504 GILATSESKsMPVLG
S506-p LATSESKsMPVLGSV
S515 PVLGSVSSVTKSALN
K524 TKSALNKKTLEAEFN
N532 TLEAEFNNPCPLTPE
C534 EAEFNNPCPLTPEPG
T537 FNNPCPLTPEPGEGP
K617 GETQPEFKEDSSGGK
S620 QPEFKEDSSGGKTGE
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