Home

CARD9 (human)

Overview CARD9 Activates NF-kappa-B via BCL10. Defects in CARD9 are the cause of familial candidiasis type 2 (CANDF2). Chronic mucocutaneous candidiasis is characterized by impaired clearance of fungal infections and results in colonization and infections of the mucosa or skin, predominantly with Candida albicans. CANDF2 is an autosomal recessive chronic mucocutaneous candidiasis. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Adaptor/scaffold Cellular Component: cytoplasm Molecular Function: protein homodimerization activity; CARD domain binding Biological Process: response to drug; response to fungus; I-kappaB kinase/NF-kappaB cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of interleukin-2 biosynthetic process; regulation of interleukin-6 biosynthetic process; positive regulation of interleukin-6 production; positive regulation of JNK cascade; positive regulation of tumor necrosis factor production; positive regulation of stress-activated MAPK cascade; regulation of apoptosis; defense response to Gram-positive bacterium; response to exogenous dsRNA; response to muramyl dipeptide; innate immune response; defense response to virus; regulation of tumor necrosis factor biosynthetic process Reference #:  Q9H257 (UniProtKB) Alt. Names/Synonyms: CARD9; caspase recruitment domain family, member 9; Caspase recruitment domain-containing protein 9; hCARD9 Gene Symbols: CARD9 Molecular weight: 62,241 Da Basal Isoelectric point: 5.79  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CARD9

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
inhibition: T531‑p, T533‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y76-p	QRTGHKGyVAFLESL
0	1		S82	GyVAFLESLELyyPQ
0	1		Y86-p	FLESLELyyPQLyKK
0	1		Y87-p	LESLELyyPQLyKKV
0	1		Y91-p	ELyyPQLyKKVtGKE
1	1		T95-p	PQLyKKVtGKEPARV
1	0		T231-p	CKVERKHtLKLRHAM
0	1		Y339-p	LRKDSKMyKDRIEAI
0	1		A354	LLQMEEVAIERDQAI
0	1		S424	QLETLVLSsDLEDGs
0	2		S425-p	LETLVLSsDLEDGsP
0	2		S431-p	SsDLEDGsPRRSQEL
0	3		S450	DLEDTQLSDKGCLAG
0	5		S460-p	GCLAGGGsPKQPFAA
1	1		T531-p	NTTGSDNtDtEGS__
1	1		T533-p	TGSDNtDtEGS____

	mouse
Y76	QRTGHKGYVAFLESL
S82	GYVAFLESLELYYPQ
Y86	FLESLELYYPQLYRK
Y87	LESLELYYPQLYRKV
Y91	ELYYPQLYRKVtGKE
T95-p	PQLYRKVtGKEPARV
T231	CKVERKHTLKLRHAM
Y339	LRKDAKMYKDRIEAI
S354-p	LLQMEEVsIERDQAM
S424-p	QLDMLILssDLEDSs
S425-p	LDMLILssDLEDSsP
S431-p	ssDLEDSsPRNSQEL
S451-p	LEEDAQLsDKGVLAD
S461-p	GVLADREsPEQPFMA
T531	NTTGSDNTDTEGS__
T533	TGSDNTDTEGS____

	rat
Y76	QRTGHKGYVAFLEsL
S82-p	GYVAFLEsLELYyPQ
Y86	FLEsLELYyPQLyRK
Y87-p	LEsLELYyPQLyRKV
Y91-p	ELYyPQLyRKVTGKE
T95	PQLyRKVTGKEPARV
T231	CKVERKHTLKLRHAM
Y339	LRKDAKMYKDRIEAI
S354	LQQMEEVSIERDQAM
S424	QLDMLILSSDLEDSS
S425	LDMLILSSDLEDSSP
S431	SSDLEDSSPRNSQEL
S451	LEEDAQLSDKGVLAD
S461	GVLADRESPEQPFVV
T531	NTTGSDNTDTEGS__
T533	TGSDNTDTEGS____

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.