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Protein Page:
NSAP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NSAP1 a heterogeneous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. A component of the spliceosome. Five alternatively spliced isoforms have been described. Isoform 1, 2 and 3 are associated with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to ACF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Note: This description may include information from UniProtKB.
Protein type: RNA binding protein; RNA splicing; Spliceosome; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6q14-q15
Cellular Component: nucleoplasm; membrane; endoplasmic reticulum; nucleus; ribonucleoprotein complex
Molecular Function: protein binding; RNA binding; nucleotide binding; poly(A) binding
Biological Process: osteoblast differentiation; RNA processing; nuclear mRNA splicing, via spliceosome; viral reproduction; RNA splicing; negative regulation of translation
Reference #:  O60506 (UniProtKB)
Alt. Names/Synonyms: dJ3J17.2; FLJ31626; Glycine- and tyrosine-rich RNA-binding protein; GRY-RBP; GRYRBP; Heterogeneous nuclear ribonucleoprotein Q; hnRNP Q; hnRNP-Q; HNRPQ; HNRPQ1; NS1-associated protein 1; NSAP1; PP68; synaptotagmin binding, cytoplasmic RNA interacting protein; Synaptotagmin-binding, cytoplasmic RNA-interacting protein; SYNCRIP
Gene Symbols: SYNCRIP
Molecular weight: 69,603 Da
Basal Isoelectric point: 8.68  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NSAP1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y47-p AEKLDEIyVAGLVAH
0 1 K66-ub ERAIEALkEFNEDGA
0 1 K81 LAVLQQFKDSDLSHV
0 1 K81-ub LAVLQQFkDSDLSHV
0 8 K100-ac AFLCGVMkTYRQREk
0 2 K100-ub AFLCGVMkTYRQREk
0 1 K107-ub kTYRQREkQGtkVAD
0 1 T110-p RQREkQGtkVADssk
0 6 K111-ub QREkQGtkVADsskG
0 1 S115-p QGtkVADsskGPDEA
0 1 S116-p GtkVADsskGPDEAk
0 5 K117-ub tkVADsskGPDEAkI
0 1 K123-m3 skGPDEAkIkALLER
1 2 K123-ub skGPDEAkIkALLER
0 1 K125-m3 GPDEAkIkALLERTG
0 1 Y144-p VTTGQRKyGGPPPDS
0 3 S159-p VYSGQQPsVGTEIFV
0 2 K168-ub GTEIFVGkIPRDLFE
0 1 K213-m1 AFVTFCTkEAAQEAV
0 1 K221-ac EAAQEAVkLYNNHEI
0 25 K221-ub EAAQEAVkLYNNHEI
0 5 S249-p NNRLFVGsIPKSKTk
0 6 K256-ub sIPKSKTkEQILEEF
0 2 K265-ub QILEEFSkVTEGLTD
0 5 K282-ac LYHQPDDkkkNRGFC
0 1 K282-ub LYHQPDDkkkNRGFC
0 1 K283-ub YHQPDDkkkNRGFCF
0 2 K283-ac YHQPDDkkkNRGFCF
0 1 K284-ub HQPDDkkkNRGFCFL
0 1 Y293-p RGFCFLEyEDHkTAA
0 7 K297-ub FLEyEDHkTAAQARR
0 1 K310-ub RRRLMSGkVkVWGNV
0 3 K312-ub RLMSGkVkVWGNVGT
0 25 K336-ub PDPEVMAkVkVLFVR
0 11 K338-ub PEVMAkVkVLFVRNL
0 1 T348-p FVRNLANtVTEEILE
0 28 K356-ub VTEEILEkAFSQFGk
0 1 K363-ac kAFSQFGkLERVKKL
0 76 K363-ub kAFSQFGkLERVKKL
0 9 K371-ub LERVKKLkDyAFIHF
1 18 Y373-p RVKKLkDyAFIHFDE
0 1 K386-ub DERDGAVkAMEEMNG
0 3 K412-ac FAKPPDQkRKERKAQ
0 5 K412-ub FAKPPDQkRKERKAQ
0 1 Y431-p KNQMYDDyyYyGPPH
0 2 Y432-p NQMYDDyyYyGPPHM
0 1 Y434-p MYDDyyYyGPPHMPP
0 4 R444-m1 PHMPPPTrGrGrGGR
0 1 R446-m1 MPPPTrGrGrGGRGG
0 1 R448-m1 PPTrGrGrGGRGGYG
0 1 Y472-p DYYDYYGyDyHNYRG
0 4 Y474-p YDYYGyDyHNYRGGY
0 8 Y485-p RGGYEDPyYGyEDFQ
0 4 Y488-p YEDPyYGyEDFQVGA
0 4 R496-m1 EDFQVGArGrGGRGA
0 1 R498-m1 FQVGArGrGGRGARG
0 1 S509-p GARGAAPsRGRGAAP
0 1 S524-p PRGRAGYsQrGGPGs
0 4 R526-m1 GRAGYsQrGGPGsAr
0 1 R526-m2 GRAGYsQrGGPGsAr
0 1 S531-p sQrGGPGsArGVRGA
0 1 R533-m1 rGGPGsArGVRGARG
0 1 K566-ac GNVGGKRkADGYNQP
0 12 K576-ac GYNQPDSkRRQtNNQ
0 2 T580-p PDSkRRQtNNQNWGs
0 5 S587-p tNNQNWGsQPIAQQP
0 1 S601-p PLQGGDHsGNYGYKS
0 10 Y614-p KSENQEFyQDTFGQQ
0 21 K623-ac DTFGQQWk_______
  mouse

 
Y47 AEKLDEIYVAGLVAH
K66 ERAIEALKEFNEDGA
K81-ac LAVLQQFkDSDLSHV
K81 LAVLQQFKDSDLSHV
K100 AFLCGVMKTYRQREK
K100-ub AFLCGVMkTYRQREK
K107 kTYRQREKQGTKVAD
T110 RQREKQGTKVADSSK
K111 QREKQGTKVADSSKG
S115 QGTKVADSSKGPDEA
S116 GTKVADSSKGPDEAK
K117 TKVADSSKGPDEAKI
K123 SKGPDEAKIKALLER
K123 SKGPDEAKIKALLER
K125 GPDEAKIKALLERTG
Y144 VTTGQRKYGGPPPDS
S159 VYSGQQPSVGTEIFV
K168-ub GTEIFVGkIPRDLFE
K213 AFVTFCTKEAAQEAV
K221 EAAQEAVKLYNNHEI
K221-ub EAAQEAVkLYNNHEI
S249-p NNRLFVGsIPKSKTK
K256 sIPKSKTKEQILEEF
K265 QILEEFSKVTEGLTD
K282 LYHQPDDKKKNRGFC
K282 LYHQPDDKKKNRGFC
K283 YHQPDDKKKNRGFCF
K283 YHQPDDKKKNRGFCF
K284 HQPDDKKKNRGFCFL
Y293 RGFCFLEYEDHKTAA
K297 FLEYEDHKTAAQARR
K310 RRRLMSGKVKVWGNV
K312 RLMSGKVKVWGNVGT
K336-ub PDPEVMAkVkVLFVR
K338-ub PEVMAkVkVLFVRNL
T348 FVRNLANTVTEEILE
K356-ub VTEEILEkSFSQFGk
K363 kSFSQFGKLERVKKL
K363-ub kSFSQFGkLERVKKL
K371 LERVKKLKDyAFIHF
Y373-p RVKKLKDyAFIHFDE
K386 DERDGAVKAMEEMNG
K412 FAKPPDQKRKERKAQ
K412 FAKPPDQKRKERKAQ
Y431 KNQMYDDYyYYGPPH
Y432-p NQMYDDYyYYGPPHM
Y434 MYDDYyYYGPPHMPP
R444 PHMPPPTRGRGRGGR
R446 MPPPTRGRGRGGRGG
R448 PPTRGRGRGGRGGYG
Y472 DYYDYYGYDYHNYRG
Y474 YDYYGYDYHNYRGGY
Y485-p RGGYEDPyYGyEDFQ
Y488-p YEDPyYGyEDFQVGA
R496-m1 EDFQVGArGRGGRGA
R498 FQVGArGRGGRGARG
S509 GARGAAPSRGRGAAP
S524 PRGRAGYSQRGGPGS
R526 GRAGYSQRGGPGSAR
R526 GRAGYSQRGGPGSAR
S531 SQRGGPGSARGVRGA
R533 RGGPGSARGVRGARG
K566 GNVGGKRKADGYNQP
K576 GYNQPDTKRRQTNNQ
T580 PDTKRRQTNNQNWGS
S587 TNNQNWGSQPIAQQP
S601 PLQGGDHSGNYGYKS
Y614 KSENQEFYQDTFGQQ
K623 DTFGQQWK_______
  rat

 
Y47 AEKLDEIYVAGQRKY
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
Y54 YVAGQRKYGGPPPDS
S69 VYSGQQPSVGTEIFV
K78 GTEIFVGKIPRDLFE
K123 AFVTFCTKEAAQEAV
K131 EAAQEAVKLYNNHEI
K131 EAAQEAVKLYNNHEI
S159-p NNRLFVGsIPKSKTK
K166 sIPKSKTKEQILEEF
K175 QILEEFSKVTEGLTD
K192 LYHQPDDKKKNRGFC
K192 LYHQPDDKKKNRGFC
K193 YHQPDDKKKNRGFCF
K193 YHQPDDKKKNRGFCF
K194 HQPDDKKKNRGFCFL
Y203 RGFCFLEYEDHKTAA
K207 FLEYEDHKTAAQARR
K220 RRRLMSGKVKVWGNV
K222 RLMSGKVKVWGNVGT
K246 PDPEVMAKVKVLFVR
K248 PEVMAKVKVLFVRNL
T258 FVRNLANTVTEEILE
K266 VTEEILEKSFSQFGK
K273 KSFSQFGKLERVKKL
K273 KSFSQFGKLERVKKL
K281 LERVKKLKDYAFIHF
Y283 RVKKLKDYAFIHFDE
K296 DERDGAVKAMEEMNG
K322 FAKPPDQKRKERKAQ
K322 FAKPPDQKRKERKAQ
Y341 KNQMYDDYYYYGPPH
Y342 NQMYDDYYYYGPPHM
Y344 MYDDYYYYGPPHMPP
R354 PHMPPPTRGRGRGGR
R356 MPPPTRGRGRGGRGG
R358 PPTRGRGRGGRGGYG
Y382 DYYDYYGYDYHNYRG
Y384 YDYYGYDYHNYRGGY
Y395 RGGYEDPYYGYEDFQ
Y398 YEDPYYGYEDFQVGA
R406 EDFQVGARGRGGRGA
R408 FQVGARGRGGRGARG
S419 GARGAAPSRGRGAAP
S434 PRGRAGYSQRGGPGS
R436 GRAGYSQRGGPGSAR
R436 GRAGYSQRGGPGSAR
S441 SQRGGPGSARGVRGA
R443 RGGPGSARGVRGARG
K476 GNVGGKRKADGYNQP
K486 GYNQPDSKRRQTNNQ
T490 PDSKRRQTNNQNWGS
S497 TNNQNWGSQPIAQQP
S511 PLQGGDHSGNYGYKS
Y524 KSENEEFYQDTFGQQ
K533 DTFGQQWK_______
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