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DKK1 (human)

Overview DKK1 Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Interacts with LRP6. Interacts (via the C-termianl Cys- rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt- mediated signaling. Placenta. Belongs to the dickkopf family. Note: This description may include information from UniProtKB. Protein type: Inhibitor protein; Secreted; Secreted, signal peptide Cellular Component: extracellular space; plasma membrane Molecular Function: protein binding; receptor antagonist activity; signal transducer activity; growth factor activity; low-density lipoprotein receptor binding Biological Process: cellular morphogenesis during differentiation; negative regulation of skeletal muscle development; response to retinoic acid; regulation of receptor internalization; negative regulation of peptidyl-serine phosphorylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of BMP signaling pathway; mesoderm formation; hair follicle development; negative regulation of mesodermal cell fate specification; endoderm formation; forebrain development; regulation of endodermal cell fate specification; negative regulation of protein complex assembly; embryonic limb morphogenesis Reference #:  O94907 (UniProtKB) Alt. Names/Synonyms: dickkopf homolog 1 (Xenopus laevis); dickkopf related protein-1; Dickkopf-1; dickkopf-1 like; Dickkopf-related protein 1; Dkk-1; DKK1; hDkk-1; SK Gene Symbols: DKK1 Molecular weight: 28,672 Da Basal Isoelectric point: 8.8  Predict pI for various phosphorylation states CST Pathways:  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below DKK1 3S2K - C=178-266 (human) 3S8V - X=183-266 (human) 3SOQ - Z=38-44 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 3S2K 3S8V 3SOQ  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y132-p	AMCCPGNyCKNGICV
0	1		T221-p	LKEGQVCtKHRRKGS
0	1		S255-p	QKDHHQAsNssRLHt
0	1		S257-p	DHHQAsNssRLHtCQ
0	1		S258-p	HHQAsNssRLHtCQR
0	1		T262-p	sNssRLHtCQRH___

	mouse
Y135	AMCCPGNYCKNGICM
T227	LKEGQVCTKHKRKGS
S261	QKDHHQASNSSRLHT
S263	DHHQASNSSRLHTCQ
S264	HHQASNSSRLHTCQR
T268	SNSSRLHTCQRH___

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