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Protein Page:
DKK1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DKK1 Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Interacts with LRP6. Interacts (via the C-termianl Cys- rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt- mediated signaling. Placenta. Belongs to the dickkopf family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide; Inhibitor protein
Cellular Component: extracellular space; plasma membrane
Molecular Function: protein binding; signal transducer activity; receptor antagonist activity; growth factor activity; low-density lipoprotein receptor binding
Biological Process: cellular morphogenesis during differentiation; negative regulation of skeletal muscle development; response to retinoic acid; negative regulation of Wnt receptor signaling pathway; regulation of receptor internalization; negative regulation of peptidyl-serine phosphorylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of BMP signaling pathway; mesoderm formation; hair follicle development; negative regulation of mesodermal cell fate specification; endoderm formation; forebrain development; regulation of endodermal cell fate specification; negative regulation of protein complex assembly; embryonic limb morphogenesis
Reference #:  O94907 (UniProtKB)
Alt. Names/Synonyms: dickkopf homolog 1 (Xenopus laevis); dickkopf related protein-1; Dickkopf-1; dickkopf-1 like; Dickkopf-related protein 1; Dkk-1; DKK1; hDkk-1; SK
Gene Symbols: DKK1
Molecular weight: 28,672 Da
Basal Isoelectric point: 8.8  Predict pI for various phosphorylation states
CST Pathways:  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DKK1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y132-p AMCCPGNyCKNGICV
0 1 S140-p CKNGICVssDQNHFR
0 1 S141-p KNGICVssDQNHFRG
0 1 T155-ga GEIEETItESFGNDH
0 1 S163-ga ESFGNDHstLDGYsR
0 1 T164-ga SFGNDHstLDGYsRR
0 1 S169-ga HstLDGYsRRttLSS
0 1 T172-ga LDGYsRRttLSSKMY
0 1 T173-ga DGYsRRttLSSKMYH
0 1 T181-ga LSSKMYHtKGQEGSV
0 1 T221-p LKEGQVCtKHRRKGS
0 1 S255-p QKDHHQAsNssRLHt
0 1 S257-p DHHQAsNssRLHtCQ
0 1 S258-p HHQAsNssRLHtCQR
0 1 T262-p sNssRLHtCQRH___
  mouse

 
Y135 AMCCPGNYCKNGICM
P143 CKNGICMPSDHSHFP
S144 KNGICMPSDHSHFPR
- gap
- gap
- gap
- gap
T178 GDGYPRRTTLTSKIY
T179 DGYPRRTTLTSKIYH
T187 LTSKIYHTKGQEGSV
T227 LKEGQVCTKHKRKGS
S261 QKDHHQASNSSRLHT
S263 DHHQASNSSRLHTCQ
S264 HHQASNSSRLHTCQR
T268 SNSSRLHTCQRH___
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