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Protein Page:
K83 (human)

Overview
K83 Defects in KRT83 are a cause of monilethrix (MLTRX). Monilethrix is an autosomal dominant hair disorder characterized clinically by alopecia and follicular papules. Affected hairs have uniform elliptical nodes of normal thickness and intermittent constrictions, internodes at which the hair easily breaks. Usually only the scalp is involved, but in severe forms, the secondary sexual hair, eyebrows, eyelashes, and nails may also be affected. Belongs to the intermediate filament family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis
Cellular Component: extracellular space; keratin filament
Molecular Function: structural molecule activity
Biological Process: epidermis development; hair cycle; aging
Reference #:  P78385 (UniProtKB)
Alt. Names/Synonyms: hard keratin, type II, 3; K83; keratin 83; keratin, hair, basic, 3; keratin, type II cuticular Hb3; keratin-83; KRT83; KRTHB3; type II hair keratin Hb3; type-II keratin Kb23
Gene Symbols: KRT83
Molecular weight: 54,195 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
Select Structure to View Below

K83

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T2 ______MTCGFNSIG
  mouse

 
S2-p ______MsCFSSRLG
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