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PhosphoSitePlus
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Protein Page:
K83 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
K83 Defects in KRT83 are a cause of monilethrix (MLTRX). Monilethrix is an autosomal dominant hair disorder characterized clinically by alopecia and follicular papules. Affected hairs have uniform elliptical nodes of normal thickness and intermittent constrictions, internodes at which the hair easily breaks. Usually only the scalp is involved, but in severe forms, the secondary sexual hair, eyebrows, eyelashes, and nails may also be affected. Belongs to the intermediate filament family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: extracellular space; keratin filament
Molecular Function: structural molecule activity
Biological Process: epidermis development; aging; hair cycle
Disease: Monilethrix
Reference #:  P78385 (UniProtKB)
Alt. Names/Synonyms: hard keratin, type II, 3; K83; keratin 83; keratin, hair, basic, 3; keratin, type II cuticular Hb3; keratin-83; KRT83; KRTHB3; type II hair keratin Hb3; type-II keratin Kb23
Gene Symbols: KRT83
Molecular weight: 54,195 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
Select Structure to View Below

K83

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T2 ______MTCGFNSIG
0 1 K350-ac NAKCQNSkLEAAVAQ
  mouse

 
S2-p ______MsCFSSRLG
K350 NAKCQNTKLEAAVTQ
  rat

 
S2 ______MSCFSSRLG
K350-ac NAKCQRAkLETAVAE
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