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Protein Page:
SENP1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SENP1 Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity. Belongs to the peptidase C48 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.22.-; Protease; EC 3.4.22.68; Nuclear receptor co-regulator
Cellular Component: nucleoplasm; nuclear membrane; focal adhesion; cytoplasm; nucleus
Molecular Function: protein binding; endopeptidase activity; SUMO-specific protease activity
Biological Process: protein desumoylation; caspase activation; cellular protein metabolic process; protein sumoylation; positive regulation of transcription from RNA polymerase II promoter; post-translational protein modification; proteolysis; negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Reference #:  Q9P0U3 (UniProtKB)
Alt. Names/Synonyms: SENP1; Sentrin-specific protease 1; Sentrin/SUMO-specific protease SENP1; SUMO1/sentrin specific peptidase 1; SUMO1/sentrin specific protease 1; SuPr-2
Gene Symbols: SENP1
Molecular weight: 73,481 Da
Basal Isoelectric point: 8.69  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SENP1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S57-p RQGHLDRsFTCSTRS
0 3 S80-p SDNPSSDsFLGSGDL
0 11 T102-p NGQWRNStPSSSSSL
0 1 S117-p QKSRNSRsLYLETRK
0 1 S130-p RKTSSGLsNsFAGKS
0 2 S132-p TSSGLsNsFAGKSNH
0 1 S149-p HVSAYEKsFPIKPVP
0 7 S157-p FPIKPVPsPSWSGSC
0 3 S170-p SCRRSLLsPKKTQRR
0 5 S180-p KTQRRHVsTAEETVQ
0 2 K227-u SRCLSSSkNTLKDSL
0 1 T334 QTPTPSSTFFQAELW
0 3 T414-p QKKGHKLtDsEDEFP
0 1 S416-p KGHKLtDsEDEFPEI
0 1 K577-u ESIDKKRkEFDTNGW
  mouse

 
S57 RQGTLDGSFTCSTRS
S80 SDNPSSDSFLGSGDV
T102 NGQWRNSTPASGSAP
S117 QKPRNSRSLCLETRK
S130 RKTSSGLSNtFVGKS
T132-p TSSGLSNtFVGKSNH
S149 HMSAYEKSFPIKPAP
S157 FPIKPAPSPSWSGSC
S170-p SCRRSLLsPKKTQRR
S180 KTQRRHFSTAEETVQ
K227 SRCLSSNKNSLKDSL
T330-p QTPASSPtFFQAELW
T410 RKKSHQLTDSEDEFP
S412 KSHQLTDSEDEFPEI
K573 ESVDKKRKEFDTNGW
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