Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity. Belongs to the peptidase C48 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protease; Nuclear receptor co-regulator; EC 3.4.22.-; EC 220.127.116.11
Molecular Function: protein binding; endopeptidase activity; SUMO-specific protease activity
Biological Process: caspase activation; protein desumoylation; protein sumoylation; cellular protein metabolic process; positive regulation of transcription from RNA polymerase II promoter; post-translational protein modification; proteolysis; negative regulation of proteasomal ubiquitin-dependent protein catabolic process
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.