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SENP1 (human)

Overview SENP1 Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity. Belongs to the peptidase C48 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Protease; Nuclear receptor co-regulator; EC 3.4.22.68; EC 3.4.22.- Cellular Component: cytoplasm; nucleus Molecular Function: endopeptidase activity; SUMO-specific protease activity Biological Process: protein desumoylation; caspase activation; positive regulation of transcription from RNA polymerase II promoter; proteolysis Reference #:  Q9P0U3 (UniProtKB) Alt. Names/Synonyms: SENP1; Sentrin-specific protease 1; Sentrin/SUMO-specific protease SENP1; SUMO1/sentrin specific peptidase 1; SUMO1/sentrin specific protease 1; SuPr-2 Gene Symbols: SENP1 Molecular weight: 73,481 Da Basal Isoelectric point: 8.69  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SENP1 2CKG - A/B=419-643 (human) 2CKH - A=419-643 (human) 2G4D - A/C=440-643 (human) 2IY0 - A=419-643 (human) 2IY1 - A/C=419-643 (human) 2IYC - A/B=419-643 (human) 2IYD - A=419-643 (human) 2XPH - A/B=415-644 (human) 2XRE - A/B=415-644 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2CKG 2CKH 2G4D 2IY0 2IY1 2IYC 2IYD 2XPH 2XRE  |  ENZYME  |  Phospho3D  |  DISEASE  |  NURSA  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S78-p	YYSDNPSsDsFLGSG
0	3		S80-p	SDNPSsDsFLGSGDL
0	11		T102-p	NGQWRNStPSSSSSL
0	1		S126-p	YLETRKTsSGLSNsF
0	1		S132-p	TsSGLSNsFAGKSNH
0	1		S149-p	HVSAYEKsFPIKPVP
0	6		S157-p	FPIKPVPsPSWSGSC
0	2		S170-p	SCRRSLLsPKKTQRR
0	5		S180-p	KTQRRHVsTAEETVQ
0	2		K227-u	SRCLSSSkNTLKDSL
0	1		T328-p	LKVKDSQtPtPSSTF
0	1		T330-p	VKDSQtPtPSSTFFQ
0	1		T334	QtPtPSSTFFQAELW
0	1		Y349-p	IKELTSVyDSRARER
0	3		T414-p	QKKGHKLtDSEDEFP
0	1		K429-a	EITEEMEkEIKNVFR
0	1		K577-u	ESIDKKRkEFDTNGW

	mouse
S78	YHSDNPSSDSFLGSG
S80	SDNPSSDSFLGSGDV
T102	NGQWRNSTPASGSAP
S126	CLETRKTSSGLSNtF
T132-p	TSSGLSNtFVGKSNH
S149	HMSAYEKSFPIKPAP
S157	FPIKPAPSPSWSGSC
S170-p	SCRRSLLsPKKTQRR
S180	KTQRRHFSTAEETVQ
K227	SRCLSSNKNSLKDSL
T324	LKVKESQTPASSPtF
A326	VKESQTPASSPtFFQ
T330-p	QTPASSPtFFQAELW
Y345	IKELTSVYDSRARER
T410	RKKSHQLTDSEDEFP
K425	EITEEMEKEIKNVFR
K573	ESVDKKRKEFDTNGW

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