Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
TOP2A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TOP2A a DNA topoisomerase. Controls of topological states of DNA by transient breakage and rejoining of DNA. Makes double-strand breaks. Four splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 5.99.1.3; Isomerase
Cellular Component: nucleoplasm; centriole; nuclear chromosome; protein complex; viral integration complex; DNA topoisomerase complex (ATP-hydrolyzing); nucleolus; condensed chromosome; nucleus
Molecular Function: protein C-terminus binding; DNA-dependent ATPase activity; DNA topoisomerase (ATP-hydrolyzing) activity; ubiquitin binding; protein homodimerization activity; histone deacetylase binding; magnesium ion binding; drug binding; protein binding; enzyme binding; protein kinase C binding; DNA binding; protein heterodimerization activity; chromatin binding; DNA bending activity; ATP binding
Biological Process: DNA unwinding during replication; ATP catabolic process; mitotic recombination; DNA topological change; phosphoinositide-mediated signaling; positive regulation of viral genome replication; positive regulation of apoptosis; sister chromatid segregation; DNA repair; apoptotic chromosome condensation; embryonic cleavage; DNA ligation; chromosome segregation; positive regulation of retroviral genome replication; resolution of meiotic joint molecules as recombinants; positive regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; DNA replication; response to DNA damage stimulus
Reference #:  P11388 (UniProtKB)
Alt. Names/Synonyms: DNA topoisomerase 2-alpha; DNA topoisomerase II, 170 kD; DNA topoisomerase II, alpha isozyme; TOP2; TOP2A; topoisomerase (DNA) II alpha 170kDa; TP2A
Gene Symbols: TOP2A
Molecular weight: 174,385 Da
Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TOP2A

Protein Structure Not Found.


STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
apoptosis, induced: S1337‑p, S1525‑p
cell cycle regulation: S1337‑p, S1525‑p
chromatin organization, altered: S1525‑p
enzymatic activity, induced: S1106‑p, S1337‑p, S1525‑p
intracellular localization: S1213‑p, S1337‑p, T1343‑p, S1525‑p
molecular association, regulation: S1106‑p, S1361‑p, S1365‑p, S1525‑p
phosphorylation: S1365‑p
protein degradation: S1361‑p, S1365‑p
ubiquitination: S1361‑p, S1365‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 10 S4-p ____MEVsPLQPVNE
0 10 S29-p EDAKKRLsVERIYQK
0 1 K123-ub ISIWNNGkGIPVVEH
0 18 K131-ub GIPVVEHkVEKMYVP
0 1 Y151-p QLLTSSNyDDDEkkV
0 24 K156-ub SNyDDDEkkVTGGRN
0 10 K157-ub NyDDDEkkVTGGRNG
0 2 S230-p LSKFKMQsLDkDIVA
0 1 K233-ub FKMQsLDkDIVALMV
0 1 S249-p RAYDIAGstKDVKVF
0 1 T250-p AYDIAGstKDVKVFL
0 1 K278-ub VDMYLKDkLDEtGNs
0 3 T282-p LKDkLDEtGNsLkVI
0 1 S285-p kLDEtGNsLkVIHEQ
0 1 K287-ub DEtGNsLkVIHEQVN
0 1 S312-p EKGFQQIsFVNSIAT
0 1 K321-ub VNSIATSkGGRHVDy
0 6 Y328-p kGGRHVDyVADQIVT
0 3 K386-ub ENMTLQPkSFGSTCQ
0 1 S395 FGSTCQLSEKFIKAA
0 1 K418-ub ILNWVKFkAQVQLNK
0 1 S452-p NDAGGRNsTECTLIL
0 1 S464-p LILTEGDsAKTLAVs
0 1 S471-p sAKTLAVsGLGVVGR
0 2 K480-ub LGVVGRDkYGVFPLR
0 3 K499-ub NVREASHkQIMENAE
0 2 K520-ub IVGLQYKkNyEDEDS
0 1 Y522-p GLQYKkNyEDEDSLk
0 3 K529-ub yEDEDSLkTLRYGKI
0 3 K579-ub EFITPIVkVSKNkQE
0 1 K584-ub IVkVSKNkQEMAFYS
0 1 T602 FEEWKSSTPNHKKWK
0 2 K611 NHKKWKVKYYkGLGT
0 1 K614-ub KWKVKYYkGLGTSTS
0 1 K622 GLGTSTSKEAKEYFA
0 2 K622-ub GLGTSTSkEAKEYFA
0 1 K639-ub KRHRIQFkYSGPEDD
0 1 K655-ub AISLAFSkkQIDDRK
0 3 K656-ub ISLAFSkkQIDDRKE
0 1 K676-ub MEDRRQRkLLGLPED
0 1 S707-p NKELILFsNsDNERs
0 2 S709-p ELILFsNsDNERsIP
0 1 S714-p sNsDNERsIPsMVDG
0 1 S717-p DNERsIPsMVDGLkP
0 1 K723-ub PsMVDGLkPGQRKVL
0 1 K798 GTRLHGGKDSASPRy
0 6 Y805-p KDSASPRyIFTMLSS
0 1 K827-ub PKDDHTLkFLYDDNQ
0 1 K893-ub LPMLPSYkNFKGtIE
0 1 T898-p SYkNFKGtIEELAPN
0 1 K936-ub RTWTQTYkEQVLEPM
0 2 K949-ub PMLNGTEkTPPLITD
0 1 K1011-ub DHVGCLKkYDTVLDI
0 1 K1028-ub DFFELRLkYYGLRKE
0 1 S1045-p LGMLGAEsAKLNNQA
0 1 K1062-ub ILEKIDGkIIIENKP
0 1 K1075-ub KPKKELIkVLIQRGY
2 20 S1106-p DEEENEEsDNEKEtE
0 2 T1112-p EsDNEKEtEKSDSVt
0 1 T1119-p tEKSDSVtDSGPTFN
0 1 K1159-ub EQELDTLkRKSPSDL
0 1 K1196-ac EQVGLPGkGGkAkGK
0 1 K1196-ub EQVGLPGkGGkAkGK
0 1 K1199-ac GLPGkGGkAkGKktQ
0 1 K1201-ac PGkGGkAkGKktQMA
0 1 K1204-ub GGkAkGKktQMAEVL
0 4 T1205-p GkAkGKktQMAEVLP
4 38 S1213-p QMAEVLPsPRGQRVI
0 1 K1228-sm PRITIEMkAEAEkkN
0 1 K1233-ac EMkAEAEkkNKkKIk
0 1 K1234-ac MkAEAEkkNKkKIkN
0 1 K1237-ac EAEkkNKkKIkNENt
0 1 K1240-sm kkNKkKIkNENtEGs
0 5 T1244-p kKIkNENtEGsPQED
1 33 S1247-p kNENtEGsPQEDGVE
0 3 G1257 EDGVELEGLkQRLEK
0 1 K1259-ub GVELEGLkQRLEKKQ
0 1 T1272-p KQKREPGtKtKkQTT
0 2 T1274-p KREPGtKtKkQTTLA
0 1 K1276-ac EPGtKtKkQTTLAFK
0 1 K1287-ac LAFKPIKkGkKRNPW
0 1 K1289-ac FKPIKkGkKRNPWsD
0 7 S1295-p GkKRNPWsDsEsDRs
0 4 S1297-p KRNPWsDsEsDRssD
0 2 S1299-p NPWsDsEsDRssDES
0 4 S1302-p sDsEsDRssDESNFD
0 4 S1303-p DsEsDRssDESNFDV
0 1 S1306 sDRssDESNFDVPPR
0 2 T1324-p PRRAATKtKFtMDLD
0 6 T1327-p AATKtKFtMDLDsDE
0 28 S1332-p KFtMDLDsDEDFsDF
1 31 S1337-p LDsDEDFsDFDEKtD
4 15 T1343-p FsDFDEKtDDEDFVP
0 11 S1351-p DDEDFVPsDAsPPKT
1 23 S1354-p DFVPsDAsPPKTKts
0 1 T1360-p AsPPKTKtsPKLsNK
2 0 S1361-p sPPKTKtsPKLsNKE
1 2 S1365-p TKtsPKLsNKELKPQ
0 1 P1371 LsNKELKPQKsVVsD
0 28 S1374-p KELKPQKsVVsDLEA
0 2 V1375 ELKPQKsVVsDLEAD
2 49 S1377-p KPQKsVVsDLEADDV
0 2 A1381 sVVsDLEADDVKGsV
0 8 S1387-p EADDVKGsVPLsssP
0 11 S1391-p VKGsVPLsssPPAtH
0 7 S1392-p KGsVPLsssPPAtHF
1 19 S1393-p GsVPLsssPPAtHFP
0 6 T1397-p LsssPPAtHFPDEtE
0 3 T1403-p AtHFPDEtEItNPVP
0 1 T1406-p FPDEtEItNPVPKKN
0 1 S1426-p TAAKSQSsTSttGAK
0 2 T1429-p KSQSsTSttGAKKRA
0 2 T1430-p SQSsTSttGAKKRAA
0 1 K1442-ub RAAPKGTkRDPALNs
0 1 R1443 AAPKGTkRDPALNsG
0 5 S1449-p kRDPALNsGVsQkPD
0 6 S1452-p PALNsGVsQkPDPAk
0 1 K1454-ub LNsGVsQkPDPAkTk
0 1 K1459-ub sQkPDPAkTkNRRKR
0 1 K1461-ub kPDPAkTkNRRKRkP
0 1 K1467-ac TkNRRKRkPstsDDs
1 127 S1469-p NRRKRkPstsDDsDs
0 78 T1470-p RRKRkPstsDDsDsN
0 89 S1471-p RKRkPstsDDsDsNF
0 7 D1473 RkPstsDDsDsNFEk
0 92 S1474-p kPstsDDsDsNFEkI
0 37 S1476-p stsDDsDsNFEkIVS
0 1 K1480-ac DsDsNFEkIVSKAVT
0 4 S1491-p KAVTSKKsKGEsDDF
0 7 S1495-p SKKsKGEsDDFHMDF
0 12 S1504-p DFHMDFDsAVAPRAK
0 3 Y1521-p RAKKPIKyLEEsDED
4 26 S1525-p PIKyLEEsDEDDLF_
13072 : Phospho-Topoisomerase II┬┐ (Ser1469) (D4F5) Rabbit mAb
  TOP2A iso2  
S4 ____MEVSPLQPVNE
S29 EDAKKRLSVERIYQK
K123 ISIWNNGKGIPVVEH
K131 GIPVVEHKVEKMYVP
Y151 QLLTSSNYDDDEKKV
K156 SNYDDDEKKVTGGRN
K157 NYDDDEKKVTGGRNG
S230 LSKFKMQSLDKDIVA
K233 FKMQSLDKDIVALMV
S249 RAYDIAGSTKDVKVF
T250 AYDIAGSTKDVKVFL
K278 VDMYLKDKLDETGNS
T282 LKDKLDETGNSLKVI
S285 KLDETGNSLKVIHEQ
K287 DETGNSLKVIHEQVN
S312 EKGFQQISFVNSIAT
K321 VNSIATSKGGRHVDY
Y328 KGGRHVDYVADQIVT
K386 ENMTLQPKSFGSTCQ
S395 FGSTCQLSEKFIKAH
K444 ILNWVKFKAQVQLNK
S478 NDAGGRNSTECTLIL
S490 LILTEGDSAKTLAVS
S497 SAKTLAVSGLGVVGR
K506 LGVVGRDKYGVFPLR
K525 NVREASHKQIMENAE
K546 IVGLQYKKNYEDEDS
Y548 GLQYKKNYEDEDSLK
K555 YEDEDSLKTLRYGKI
K605 EFITPIVKVSKNKQE
K610 IVKVSKNKQEMAFYS
T628 FEEWKSSTPNHKKWK
K637 NHKKWKVKYYKGLGT
K640 KWKVKYYKGLGTSTS
K648 GLGTSTSKEAKEYFA
K648 GLGTSTSKEAKEYFA
K665 KRHRIQFKYSGPEDD
K681 AISLAFSKKQIDDRK
K682 ISLAFSKKQIDDRKE
K702 MEDRRQRKLLGLPED
S733 NKELILFSNSDNERS
S735 ELILFSNSDNERSIP
S740 SNSDNERSIPSMVDG
S743 DNERSIPSMVDGLKP
K749 PSMVDGLKPGQRKVL
K824 GTRLHGGKDSASPRY
Y831 KDSASPRYIFTMLSS
K853 PKDDHTLKFLYDDNQ
K919 LPMLPSYKNFKGTIE
T924 SYKNFKGTIEELAPN
K962 RTWTQTYKEQVLEPM
K975 PMLNGTEKTPPLITD
K1037 DHVGCLKKYDTVLDI
K1054 DFFELRLKYYGLRKE
S1071 LGMLGAESAKLNNQA
K1088 ILEKIDGKIIIENKP
K1101 KPKKELIKVLIQRGY
S1132 DEEENEESDNEKETE
T1138 ESDNEKETEKSDSVT
T1145 TEKSDSVTDSGPTFN
K1185 EQELDTLKRKSPSDL
K1222 EQVGLPGKGGKAKGK
K1222 EQVGLPGKGGKAKGK
K1225 GLPGKGGKAKGKKTQ
K1227 PGKGGKAKGKKTQMA
K1230 GGKAKGKKTQMAEVL
T1231 GKAKGKKTQMAEVLP
S1239-p QMAEVLPsPRGQRVI
K1254 PRITIEMKAEAEKKN
K1259 EMKAEAEKKNKKKIK
K1260 MKAEAEKKNKKKIKN
K1263 EAEKKNKKKIKNENT
K1266 KKNKKKIKNENTEGS
T1270 KKIKNENTEGSPQED
S1273 KNENTEGSPQEDGVE
G1283 EDGVELEGLKQRLEK
K1285 GVELEGLKQRLEKKQ
T1298 KQKREPGTKTKKQTT
T1300 KREPGTKTKKQTTLA
K1302 EPGTKTKKQTTLAFK
K1313 LAFKPIKKGKKRNPW
K1315 FKPIKKGKKRNPWSD
S1321 GKKRNPWSDSESDRS
S1323 KRNPWSDSESDRSSD
S1325 NPWSDSESDRSSDES
S1328 SDSESDRSSDESNFD
S1329 DSESDRSSDESNFDV
S1332 SDRSSDESNFDVPPR
T1350 PRRAATKTKFTMDLD
T1353 AATKTKFTMDLDSDE
S1358 KFTMDLDSDEDFSDF
S1363 LDSDEDFSDFDEKTD
T1369 FSDFDEKTDDEDFVP
S1377 DDEDFVPSDASPPKT
S1380 DFVPSDASPPKTKTS
T1386 ASPPKTKTSPKLSNK
S1387 SPPKTKTSPKLSNKE
S1391 TKTSPKLSNKELKPQ
P1397 LSNKELKPQKsVVSD
S1400-p KELKPQKsVVSDLEA
V1401 ELKPQKsVVSDLEAD
S1403 KPQKsVVSDLEADDV
A1407 sVVSDLEADDVKGSV
S1413 EADDVKGSVPLSSsP
S1417 VKGSVPLSSsPPATH
S1418 KGSVPLSSsPPATHF
S1419-p GSVPLSSsPPATHFP
T1423 LSSsPPATHFPDETE
T1429 ATHFPDETEITNPVP
T1432 FPDETEITNPVPKKN
S1452 TAAKSQSSTSTTGAK
T1455 KSQSSTSTTGAKKRA
T1456 SQSSTSTTGAKKRAA
K1468 RAAPKGTKRDPALNS
R1469 AAPKGTKRDPALNSG
S1475 KRDPALNSGVSQKPD
S1478 PALNSGVSQKPDPAK
K1480 LNSGVSQKPDPAKTK
K1485 SQKPDPAKTKNRRKR
K1487 KPDPAKTKNRRKRKP
K1493 TKNRRKRKPstsDDs
S1495-p NRRKRKPstsDDsDs
T1496-p RRKRKPstsDDsDsN
S1497-p RKRKPstsDDsDsNF
D1499 RKPstsDDsDsNFEK
S1500-p KPstsDDsDsNFEKI
S1502-p stsDDsDsNFEKIVS
K1506 DsDsNFEKIVSKAVT
S1517 KAVTSKKSKGESDDF
S1521 SKKSKGESDDFHMDF
S1530 DFHMDFDSAVAPRAK
Y1547 RAKKPIKYLEESDED
S1551 PIKYLEESDEDDLF_
  mouse

 
S4-p ____MELsPLQPVNE
S28-p EDGKKRLsIERIYQK
K122 ISIWNNGKGIPVVEH
K130 GIPVVEHKVEKIYVP
Y150 QLLTSSNYDDDEkkV
K155-ub SNYDDDEkkVTGGRN
K156-ub NYDDDEkkVTGGRNG
S229-p LSKFKMQsLDKDIVA
K232 FKMQsLDKDIVALMV
S248 RAYDIAGSTKDVKVF
T249 AYDIAGSTKDVKVFL
K277 VDLYLKDKVDETGNS
T281 LKDKVDETGNSLKVI
S284 KVDETGNSLKVIHEQ
K286 DETGNSLKVIHEQVN
S311 ERGFQQISFVNSIAT
K320 VNSIATSKGGRHVDy
Y327-p KGGRHVDyVADQIVS
K385 ENMTLQAKSFGSTCQ
S394-p FGSTCQLsEKFIKAA
K417 ILNWVKFKAQIQLNK
S451 NDAGSRNSTECTLIL
S463 LILTEGDSAKTLAVS
S470 SAKTLAVSGLGVVGR
K479 LGVVGRDKYGVFPLR
K498 NVREASHKQIMENAE
K519 IVGLQYKKNYEDEDS
Y521 GLQYKKNYEDEDSLK
K528 YEDEDSLKTLRYGKI
K578 EFITPIVKVSKNKQE
K583 IVKVSKNKQEIAFYS
T601-p FEEWKSStPNHKKWK
K610-ac NHKKWKVkYYKGLGT
K613 KWKVkYYKGLGTSTS
K621-ac GLGTSTSkEAKEYFA
K621-ub GLGTSTSkEAKEYFA
K638 KRHRIQFKYSGPEDD
K654 AISLAFSKKQVDDRK
K655 ISLAFSKKQVDDRKE
K675 MEDRRQRKLLGLPED
S706 NKELILFSNSDNERS
S708 ELILFSNSDNERSIP
S713 SNSDNERSIPSMVDG
S716 DNERSIPSMVDGLKP
K722 PSMVDGLKPGQRKVL
K797-ub GTRLHGGkDSASPRY
Y804 kDSASPRYIFTMLSP
R826 PKDDHTLRFLYDDNQ
K892 LPMLPSYKNFKGTIE
T897 SYKNFKGTIEELASN
K935 RTWTQTYKEQVLEPM
K948 PMLNGTEKTPSLITD
K1010 DHVGCLKKYDTVLDI
K1027 DFFELRLKYYGLRKE
S1044 LGMLGAESSKLNNQA
K1061 ILEKIDGKIVIENKP
K1074 KPKKELIKVLIQRGY
S1105-p DEEENEEsDTETSTS
T1109 NEEsDTETSTSDSAA
A1116 TSTSDSAAEAGPTFN
K1156 EQELNTLKQKSPSDL
K1193 EQVGLPGKAGKAKGK
K1193 EQVGLPGKAGKAKGK
K1196 GLPGKAGKAKGKKAQ
K1198 PGKAGKAKGKKAQMC
K1201 AGKAKGKKAQMCADV
A1202 GKAKGKKAQMCADVL
S1211-p MCADVLPsPRGKRVI
K1226 PQVTVEMKAEAEKKI
K1231 EMKAEAEKKIRKKIK
K1232 MKAEAEKKIRKKIKS
K1235 EAEKKIRKKIKSENV
K1238 KKIRKKIKSENVEGt
V1242 KKIKSENVEGtPAED
T1245-p KSENVEGtPAEDGAE
S1255-p EDGAEPGsLRQRIEK
R1257 GAEPGsLRQRIEKKQ
- gap
A1270 KQKKEPGAKKQTTLP
K1272 KKEPGAKKQTTLPFK
K1283 LPFKPVKKGRKKNPW
R1285 FKPVKKGRKKNPWsD
S1291-p GRKKNPWsDsEsDVs
S1293-p KKNPWsDsEsDVssN
S1295-p NPWsDsEsDVssNEs
S1298-p sDsEsDVssNEsNVD
S1299-p DsEsDVssNEsNVDV
S1302-p sDVssNEsNVDVPPR
A1320 QRSAAAKAKFtVDLD
T1323-p AAAKAKFtVDLDsDE
S1328-p KFtVDLDsDEDFsGL
S1333-p LDsDEDFsGLDEKDE
D1339 FsGLDEKDEDEDFLP
L1347 EDEDFLPLDAtPPKA
T1350-p DFLPLDAtPPKAKIP
I1356 AtPPKAKIPPKNTKK
P1357 tPPKAKIPPKNTKKA
T1361 AKIPPKNTKKALKtQ
T1367-p NTKKALKtQGssMsV
S1370-p KALKtQGssMsVVDL
S1371-p ALKtQGssMsVVDLE
S1373-p KtQGssMsVVDLEsD
S1379-p MsVVDLEsDVKDsVP
S1384-p LEsDVKDsVPAsPGV
S1388-p VKDsVPAsPGVPAAD
P1389 KDsVPAsPGVPAADF
G1390 DsVPAsPGVPAADFP
A1394 AsPGVPAADFPAETE
T1400 AADFPAETEQSKPSK
S1403 FPAETEQSKPSKKTV
S1422 TATKSQSSVSTAGTK
T1425 KSQSSVSTAGTKKRA
A1426 SQSSVSTAGTKKRAA
K1438 RAAPKGTKsDSALSA
S1439-p AAPKGTKsDSALSAR
A1445 KsDSALSARVSEKPA
S1448 SALSARVSEKPAPAK
K1450 LSARVSEKPAPAKAK
K1455 SEKPAPAKAKNSRKR
K1457 KPAPAKAKNSRKRKP
K1463 AKNSRKRKPsssDss
S1465-p NSRKRKPsssDssDs
S1466-p SRKRKPsssDssDsD
S1467-p RKRKPsssDssDsDF
S1469-p RKPsssDssDsDFER
S1470-p KPsssDssDsDFERA
S1472-p sssDssDsDFERAIS
R1476 ssDsDFERAISKGAT
A1487 KGATSKKAKGEEQDF
E1491 SKKAKGEEQDFPVDL
D1500 DFPVDLEDTIAPRAK
Y1517 RARKPIKYLEEsDDD
S1521-p PIKYLEEsDDDDDLF
  rat

 
S4 ____MELSPLQPVNE
S28-p EDGKKRLsVERIYQK
K121 ISIWNNGKGIPVVEH
K129 GIPVVEHKVEKMYVP
Y149 QLLTSSNYDDDEKKV
K154 SNYDDDEKKVTGGRN
K155 NYDDDEKKVTGGRNG
S228 LSKFKMQSLDKDIVA
K231 FKMQSLDKDIVALMV
S247 RAYDIAGSTKDVKVF
T248 AYDIAGSTKDVKVFL
K276 VDMYLKDKVDETGNA
T280 LKDKVDETGNALKVV
A283 KVDETGNALKVVHEQ
K285 DETGNALKVVHEQVN
S310 EKGFQQISFVNSIAT
K319 VNSIATSKGGRHVDY
Y326 KGGRHVDYVADQIVS
K384 ENMTLQAKSFGSTCQ
S393 FGSTCQLSEKFIKAA
K416 ILNWVKFKAQIQLNK
S450 NDAGSRNSAECTLIL
S462 LILTEGDSAKTLAVS
S469 SAKTLAVSGLGVVGR
K478 LGVVGRDKYGVFPLR
K497 NVREASHKQIMENAE
K518 IVGLQYKKNYEDEDS
Y520 GLQYKKNYEDEDSLK
K527 YEDEDSLKTLRYGKI
K577 EFITPIVKVSKNKQE
K582 IVKVSKNKQEIAFYS
N600 FEEWKSTNPNHKKWK
K609 NHKKWKVKYYKGLGT
K612 KWKVKYYKGLGTSTS
K620 GLGTSTSKEAKEYFA
K620 GLGTSTSKEAKEYFA
K637 KRHRIQFKYSGPEDD
K653 AISLAFSKKQVDDRK
K654 ISLAFSKKQVDDRKE
K674 MEDRRQRKLLGLPED
S705 NKELILFSNSDNERS
S707 ELILFSNSDNERSIP
S712 SNSDNERSIPSMVDG
S715 DNERSIPSMVDGLKP
K721 PSMVDGLKPGQRKVL
K796 GTRLHGGKDSASPRY
Y803 KDSASPRYIFTMLSP
R825 SKDDHTLRFLYDDNQ
K891 LPMLPSYKNYKGTIE
T896 SYKNYKGTIEELASN
K934 RTWTQTYKEQVLEPM
K947 PMLNGTEKTPPLITD
K1009 DHVGCLKKYDTVLDI
K1026 DFFELRLKYYGLRKE
S1043 LGMLGAESSKLNNQA
K1060 ILEKIDGKIVIENKP
K1073 KPKKELIKVLIQRGY
N1104 EEEENEENEESESES
S1109 EENEESESESTSPAA
A1116 SESTSPAAESGPTFN
K1156 EQELNTLKKKTPSDL
K1193 EQVGLPGKGVKAKGK
K1193 EQVGLPGKGVKAKGK
K1196 GLPGKGVKAKGKKAQ
K1198 PGKGVKAKGKKAQIS
K1201 GVKAKGKKAQISEVL
A1202 VKAKGKKAQISEVLP
S1210-p QISEVLPsPVGKRVI
R1225 PQVTMEMRAEAEKKI
K1230 EMRAEAEKKIRRKIK
K1231 MRAEAEKKIRRKIKS
R1234 EAEKKIRRKIKSENV
K1237 KKIRRKIKSENVEGt
V1241 RKIKSENVEGtPAED
T1244-p KSENVEGtPAEDGAE
G1253 AEDGAEPGLRQRLEK
R1255 DGAEPGLRQRLEKRQ
T1268 RQKREPGTRAKKQTT
A1270 KREPGTRAKKQTTLP
K1272 EPGTRAKKQTTLPFK
K1283 LPFKPIKKAQKQNPW
Q1285 FKPIKKAQKQNPWSD
S1291 AQKQNPWSDSESDMS
S1293 KQNPWSDSESDMSSN
S1295 NPWSDSESDMSSNES
S1298 SDSESDMSSNESNFD
S1299 DSESDMSSNESNFDV
S1302 SDMSSNESNFDVPPR
A1320 PRIAATKAKFTADLD
T1323 AATKAKFTADLDsDD
S1328-p KFTADLDsDDDFsGL
S1333-p LDsDDDFsGLDEKDE
D1339 FsGLDEKDEDEDFFP
L1347 EDEDFFPLDDtPPKT
T1350-p DFFPLDDtPPKTKMP
M1356 DtPPKTKMPPKNTKK
P1357 tPPKTKMPPKNTKKA
T1361 TKMPPKNTKKALKPQ
P1367 NTKKALKPQKSSTsV
S1370 KALKPQKSSTsVDLE
S1371 ALKPQKSSTsVDLEs
S1373-p KPQKSSTsVDLEsDG
S1378-p STsVDLEsDGKDsVP
S1383-p LEsDGKDsVPAsPGA
S1387-p GKDsVPAsPGASAAD
P1388 KDsVPAsPGASAADV
G1389 DsVPAsPGASAADVP
A1393 AsPGASAADVPAETE
T1399 AADVPAETEPSKPSS
S1402 VPAETEPSKPSSKQT
L1422 TITKGQSLTSTAGTK
T1425 KGQSLTSTAGTKKRA
A1426 GQSLTSTAGTKKRAV
K1438 RAVPKETKSDSALNA
S1439 AVPKETKSDSALNAH
A1445 KSDSALNAHVSKKPA
S1448 SALNAHVSKKPAPAK
K1450 LNAHVSKKPAPAKAK
K1455 SKKPAPAKAKNSRKR
K1457 KPAPAKAKNSRKRMP
M1463 AKNSRKRMPSSSDSS
S1465 NSRKRMPSSSDSSDS
S1466 SRKRMPSSSDSSDSE
S1467 RKRMPSSSDSSDSEF
S1469 RMPSSSDSSDSEFEK
S1470 MPSSSDSSDSEFEKA
S1472 SSSDSSDSEFEKAIS
K1476 SSDSEFEKAISKGAT
L1487 KGATSKKLKGEERDF
E1491 SKKLKGEERDFHVDL
D1500 DFHVDLDDTVAPRAK
Y1517 RARKPIKYLEESDDD
S1521 PIKYLEESDDDLF__
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.