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Protein Page:
UGT1A3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
UGT1A3 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Belongs to the UDP-glycosyltransferase family. 1 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450; Membrane protein, integral; EC 2.4.1.17; Cofactor and Vitamin Metabolism - retinol; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Carbohydrate Metabolism - starch and sucrose; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - pentose and glucuronate interconversions; Xenobiotic Metabolism - drug metabolism - other enzymes; Lipid Metabolism - androgen and estrogen; Transferase
Cellular Component: endoplasmic reticulum membrane; integral to membrane
Molecular Function: protein homodimerization activity; retinoic acid binding; enzyme binding; glucuronosyltransferase activity; protein heterodimerization activity; UDP-glycosyltransferase activity
Biological Process: metabolic process; retinoic acid metabolic process
Reference #:  P35503 (UniProtKB)
Alt. Names/Synonyms: GNT1; UD13; UDP glucuronosyltransferase 1 family, polypeptide A3; UDP glucuronosyltransferase 1A3; UDP glycosyltransferase 1 family, polypeptide A3; UDP-glucuronosyltransferase 1-3; UDP-glucuronosyltransferase 1-C; UDP-glucuronosyltransferase 1A3; UDPGT; UDPGT 1-3; UGT-1C; UGT1; UGT1*3; UGT1-03; UGT1.3; UGT1A3; UGT1C
Gene Symbols: UGT1A3
Molecular weight: 60,338 Da
Basal Isoelectric point: 8.41  Predict pI for various phosphorylation states
Select Structure to View Below

UGT1A3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 10 K354 ANNTILVKWLPQNDL
  mouse

 
K353-a AKNTILVkWLPQNDL
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