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Protein Page:
UGT1A3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

UGT1A3 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Belongs to the UDP-glycosyltransferase family. 1 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Carbohydrate Metabolism - ascorbate and aldarate; Xenobiotic Metabolism - drug metabolism - other enzymes; EC; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Xenobiotic Metabolism - metabolism by cytochrome P450; Transferase; Lipid Metabolism - androgen and estrogen; Carbohydrate Metabolism - starch and sucrose; Carbohydrate Metabolism - pentose and glucuronate interconversions; Cofactor and Vitamin Metabolism - retinol
Cellular Component: endoplasmic reticulum membrane; integral to membrane
Molecular Function: protein homodimerization activity; enzyme binding; retinoic acid binding; glucuronosyltransferase activity; protein heterodimerization activity; UDP-glycosyltransferase activity
Biological Process: metabolic process; retinoic acid metabolic process
Reference #:  P35503 (UniProtKB)
Alt. Names/Synonyms: GNT1; UD13; UDP glucuronosyltransferase 1 family, polypeptide A3; UDP glucuronosyltransferase 1A3; UDP glycosyltransferase 1 family, polypeptide A3; UDP-glucuronosyltransferase 1-3; UDP-glucuronosyltransferase 1-C; UDP-glucuronosyltransferase 1A3; UDPGT; UDPGT 1-3; UGT-1C; UGT1; UGT1*3; UGT1-03; UGT1.3; UGT1A3; UGT1C
Gene Symbols: UGT1A3
Molecular weight: 60,338 Da
Basal Isoelectric point: 8.41  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend

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SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.



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