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Protein Page:
TFR2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TFR2 Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Defects in TFR2 are a cause of hemochromatosis type 3 (HFE3). HFE3 is a disorder of iron hemostasis resulting in iron overload and has a phenotype indistinguishable from that of hereditary hemochromatosis (HH). HH is characterized by abnormal intestinal iron absorption and progressive increase of total body iron, which results in midlife in clinical complications including cirrhosis, cardiopathy, diabetes, endocrine dysfunctions, arthropathy, and susceptibility to liver cancer. Since the disease complications can be effectively prevented by regular phlebotomies, early diagnosis is most important to provide a normal life expectancy to the affected subjects. Belongs to the peptidase M28 family. M28B subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 7q22
Cellular Component: integral to plasma membrane; cytoplasm
Molecular Function: peptidase activity; transferrin receptor activity
Biological Process: receptor-mediated endocytosis; cellular iron ion homeostasis; proteolysis; iron ion transport
Reference #:  Q9UP52 (UniProtKB)
Alt. Names/Synonyms: HFE3; MGC126368; TFR2; TFRC2; transferrin receptor 2; Transferrin receptor protein 2
Gene Symbols: TFR2
Molecular weight: 88,755 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
Select Structure to View Below

TFR2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 26 Y23-p PRSSQTVyQrVEGPr
0 1 R25-m1 SSQTVyQrVEGPrkG
0 1 R30-m1 yQrVEGPrkGHLEEE
1 0 K31-ub QrVEGPrkGHLEEEE
0 1 A182 LTQDIRAALSRQKLD
0 1 K609-ub DTYENLHkVLQGRLP
0 1 K665-ub NEFSGDLkARGLTLQ
0 1 T670 DLkARGLTLQWVYSA
0 1 Q690 RAAEKLRQEIYSSEE
0 1 S753-p DHLRLLRsNSSGTPG
0 1 T765-p TPGATSStGFQESRF
  mouse

 
Y23 PRPSQTIYRRVEGPQ
R25 PSQTIYRRVEGPQLE
Q30 YRRVEGPQLEHLEEE
L31 RRVEGPQLEHLEEED
K177-ub LVQDILDkLSRQKLD
K604 DTYENLHKMLRGRLP
K660 NEFSGDLKERGLtLQ
T665-p DLKERGLtLQWVYSA
K685-ub RAAEKLRkEIYSSER
A748 DHLRMLRADGSGAAS
L762 SSRLTAGLGFQESRF
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