a non-receptor protein-tyrosine phosphatase. Preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. Its noncatalytic N-terminus can interact with MAP kinases and suppress the MAP kinase activities. Shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Three alternatively spliced transcript variants of this gene, which encode two distinct isoforms, are reported. May play a role in the regulation of lymphocyte development. Note: This description may include information from UniProtKB.
Protein type: EC 184.108.40.206; Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: internal side of plasma membrane; cytoskeleton; cytoplasm; cytosol
Molecular Function: protein binding; protein tyrosine phosphatase activity
Biological Process: protein amino acid dephosphorylation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.