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Protein Page:
HePTP iso3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HePTP iso3 a non-receptor protein-tyrosine phosphatase. Preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. Its noncatalytic N-terminus can interact with MAP kinases and suppress the MAP kinase activities. Shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Three alternatively spliced transcript variants of this gene, which encode two distinct isoforms, are reported. May play a role in the regulation of lymphocyte development. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48
Cellular Component: internal side of plasma membrane; cytoskeleton; cytoplasm; cytosol
Molecular Function: protein binding; protein tyrosine phosphatase activity
Biological Process: protein amino acid dephosphorylation
Reference #:  B4DZD9 (UniProtKB)
Alt. Names/Synonyms: BPTP-4; HePTP; protein tyrosine phosphatase, non-receptor type 7; PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform 3
Gene Symbols: PTPN7
Molecular weight: 48,313 Da
Basal Isoelectric point: 8.29  Predict pI for various phosphorylation states
Select Structure to View Below

HePTP iso3

Protein Structure Not Found.


Wikipedia  |  Scansite  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 2 - gap
0 1 T23-p LSLGAAMtQPPPEKT
3 36 S44-p RLQERRGsNVALMLD
0 5 S54-p ALMLDVRsLGAVEPI
3 50 T66-p EPICSVNtPREVTLH
3 6 S93-p ALQRQPPsPKQLEEE
0 3 S110-p KIPSNFVsPEDLDIP
0 1 S134 TILPNPQSRVCLGRA
0 95 S143-p VCLGRAQsQEDGDyI
0 88 Y149-p QsQEDGDyINANyIR
0 2 Y154-p GDyINANyIRGYDGK
0 6 Y215-p WPTEEETyGPFQIRI
0 2 K226-ub QIRIQDMkECPEYTV
1 0 S246-p QYQEERRsVKHILFS
0 1 S359-p GQLPEEPsP______
  HePTP iso3  
S23-p GRGSGQRsLGLGGHP
T38-p SGPRHPGtPAAKRTW
T97 LSLGAAMTQPPPEKT
S118-p RLQERRGsNVALMLD
S128-p ALMLDVRsLGAVEPI
T140-p EPICSVNtPREVTLH
S167-p ALQRQPPsPKQLEEE
S184-p KIPSNFVsPEDLDIP
S208 TILPNPQSRVCLGRA
S217-p VCLGRAQsQEDGDyI
Y223-p QsQEDGDyINANYIR
Y228 GDyINANYIRGYDGK
Y289-p WPTEEETyGPFQIRI
K300 QIRIQDMKECPEYTV
S320 QYQEERRSVKHILFS
S433 GQLPEEPSP______
  mouse

 
- gap
- gap
T23 LSLGADMTQPPPTKA
S44 RLQERRGSSVALMLD
S54 ALMLDVQSLGTVEPI
T66-p EPICSVNtPREVTLH
S93-p TLQHQPPsPKQLEEE
N110 KIPSNFVNPEDLDIP
S134-p TILPNPQsRVCLGRA
S143-p VCLGRAQsQEDSDYI
Y149 QsQEDSDYINANYIR
Y154 SDYINANYIRGYDGK
Y215 WPTEEEAYGPFQIRI
K226 QIRIQDMKEHPEYTV
S246 QHQQECRSVKHILFS
N358 AQLPPEPNP______
  rat

 
- gap
- gap
T23 LSLGADMTQPPPAKA
S44 RLQERRGSSVALMLD
S54 ALMLDVRSLGTVEPI
T66 EPICSVNTPREVTLH
S93-p TLQHQPPsPKQLEEE
N110 KIPSNFVNPEDLDIP
S134 TILPNPQSRVCLGRA
S143 VCLGRAHSQEDSDYI
Y149 HSQEDSDYINANYIR
Y154 SDYINANYIRGYDGK
Y215 WPTEEEAYGPFQIRI
K226 QIRIQGMKEHPEYTV
S246 QHQQECRSVKHILFS
D358 AQLPPETDP______
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