Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
PECAM-1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PECAM-1 a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions. Plays a role in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, cell migration, negative regulation of immune cell signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. Undergoes alternative splicing, generating multiple isoforms in vascular beds of various tissues. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 17q23.3
Cellular Component: extracellular space; platelet alpha granule membrane; integral to membrane; plasma membrane; cell junction
Molecular Function: protein binding
Biological Process: platelet activation; extracellular matrix organization and biogenesis; platelet degranulation; diapedesis; cell recognition; cell adhesion; signal transduction; blood coagulation; leukocyte migration; phagocytosis
Reference #:  P16284 (UniProtKB)
Alt. Names/Synonyms: adhesion molecule; CD31; CD31 antigen; CD31/EndoCAM; EndoCAM; FLJ58394; GPIIA'; PECA1; PECAM-1; PECAM-1, CD31/EndoCAM; PECAM1; Platelet endothelial cell adhesion molecule; platelet/endothelial cell adhesion molecule
Gene Symbols: PECAM1
Molecular weight: 82,536 Da
Basal Isoelectric point: 6.55  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PECAM-1

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept


Sites Implicated In
cell adhesion, altered: Y690‑p, Y713‑p
cell motility, altered: Y713‑p
cytoskeletal reorganization: Y690‑p, Y713‑p
endocytosis, induced: Y713‑p
activity, induced: Y690‑p, Y713‑p
intracellular localization: Y713‑p
molecular association, regulation: Y690‑p, S700‑p, Y713‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K167 PIHFTIEKLELNEKM
0 1 Y290-p RHGNKAVySVMAMVE
0 1 S409-p IVVCEMLsQPRISYD
0 1 Q418 PRISYDAQFEVIKGQ
0 1 N467 DPAVFKDNPTEDVEY
0 1 S583-p NRANHASsVPRsKIL
0 1 S587-p HASsVPRsKILTVRV
0 1 Y623-p LIIAAKCyFLRKAKA
0 9 Y663-p NMEANSHyGHNDDVR
0 1 V669 HyGHNDDVRNHAMKP
0 3 S686-p DNKEPLNsDVQytEV
8 43 Y690-p PLNsDVQytEVQVSS
0 3 T691-p LNsDVQytEVQVSSA
1 3 S700-p VQVSSAEsHKDLGKK
0 8 T709-p KDLGKKDtEtVysEV
0 16 T711-p LGKKDtEtVysEVRK
11 787 Y713-p KKDtEtVysEVRKAV
0 28 S714-p KDtEtVysEVRKAVP
1 2 Y728-p PDAVESRysRTEGsL
0 1 S729-p DAVESRysRTEGsLD
0 1 S734-p RysRTEGsLDGt___
0 1 T738-p TEGsLDGt_______
  mouse

 
K157 PIFFKIEKLEVGTKF
Y279 KQSSEAVYSVMAMVE
S398 IQVCEMLSKPSIFHD
- under review  
K456 DPATFTDKPTRDMEY
S573 RASSMRTSPRSSTLA
S576 SMRTSPRSSTLAVRV
Y612 LIVAAKCYFLRKAKA
Y652 SVEANSHYGYDDVsG
S658-p HYGYDDVsGNDAVKP
M675 QNKDPQNMDVEyTEV
Y679-p PQNMDVEyTEVEVSS
T680 QNMDVEyTEVEVSSL
P689 VEVSSLEPHQALGTR
T698 QALGTRATETVysEI
T700 LGTRATETVysEIRK
Y702-p TRATETVysEIRKVD
S703-p RATETVysEIRKVDP
Y717-p PNLMENRySRTEGSL
S718 NLMENRySRTEGSLN
S723 RySRTEGSLNGT___
T727 TEGSLNGT_______
  rat

 
K157-ac PIYFKIEkVELGTKN
Y279 KQSKEAVYSVMALVE
S398 VQVCEMLSKPRIFHD
K407-ac PRIFHDAkFEIIKGQ
K456-ac DPVTFTDkPTRDMEY
S572 NRASIVTSLRSGPLT
S575 SIVTSLRSGPLTVRV
Y611 LIVAAKYYFLRKAKA
Y651 SVETNSHYDSQNMDV
- gap
M656 SHYDSQNMDVEYTEV
Y660 SQNMDVEYTEVEVSS
T661 QNMDVEYTEVEVSSL
P670 VEVSSLEPHQENGRL
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.