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Protein Page:
PECAM-1 (human)

Overview
PECAM-1 a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions. Plays a role in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, cell migration, negative regulation of immune cell signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. Undergoes alternative splicing, generating multiple isoforms in vascular beds of various tissues. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cell adhesion
Cellular Component: extracellular space; platelet alpha granule membrane; plasma membrane; integral to membrane; cell junction
Molecular Function: protein binding
Biological Process: platelet activation; extracellular matrix organization and biogenesis; platelet degranulation; diapedesis; cell recognition; signal transduction; blood coagulation; cell adhesion; leukocyte migration; phagocytosis
Reference #:  P16284 (UniProtKB)
Alt. Names/Synonyms: adhesion molecule; CD31; CD31 antigen; CD31/EndoCAM; EndoCAM; FLJ58394; GPIIA'; PECA1; PECAM-1; PECAM-1, CD31/EndoCAM; PECAM1; Platelet endothelial cell adhesion molecule; platelet/endothelial cell adhesion molecule
Gene Symbols: PECAM1
Molecular weight: 82,536 Da
Basal Isoelectric point: 6.55  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PECAM-1

Protein Structure Not Found.


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Sites Implicated In
cell adhesion, altered: Y690‑p, Y713‑p
cell motility, altered: Y713‑p
cytoskeletal reorganization: Y690‑p, Y713‑p
endocytosis, induced: Y713‑p
activity, induced: Y690‑p, Y713‑p
intracellular localization: Y713‑p
molecular association, regulation: Y690‑p, S700‑p, Y713‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y290-p RHGNKAVySVMAMVE
0 1 S409-p IVVCEMLsQPRISYD
0 1 S583-p NRANHASsVPRsKIL
0 1 S587-p HASsVPRsKILTVRV
0 1 Y623-p LIIAAKCyFLRKAKA
0 9 Y663-p NMEANSHyGHNDDVR
0 1 V669 HyGHNDDVRNHAMKP
0 3 S686-p DNKEPLNsDVQytEV
8 43 Y690-p PLNsDVQytEVQVSS
0 3 T691-p LNsDVQytEVQVSSA
1 3 S700-p VQVSSAEsHKDLGKK
0 8 T709-p KDLGKKDtEtVysEV
0 16 T711-p LGKKDtEtVysEVRK
11 787 Y713-p KKDtEtVysEVRKAV
0 28 S714-p KDtEtVysEVRKAVP
1 2 Y728-p PDAVESRysRTEGSL
0 1 S729-p DAVESRysRTEGSLD
0 1 T738-p TEGSLDGt_______
  mouse

 
Y279 KQSSEAVYSVMAMVE
S398 IQVCEMLSKPSIFHD
S573 RASSMRTSPRSSTLA
S576 SMRTSPRSSTLAVRV
Y612 LIVAAKCYFLRKAKA
Y652 SVEANSHYGYDDVsG
S658-p HYGYDDVsGNDAVKP
M675 QNKDPQNMDVEyTEV
Y679-p PQNMDVEyTEVEVSS
T680 QNMDVEyTEVEVSSL
P689 VEVSSLEPHQALGTR
T698 QALGTRATETVysEI
T700 LGTRATETVysEIRK
Y702-p TRATETVysEIRKVD
S703-p RATETVysEIRKVDP
Y717-p PNLMENRySRTEGSL
S718 NLMENRySRTEGSLN
T727 TEGSLNGT_______
  rat

 
Y279 KQSKEAVYSVMALVE
S398 VQVCEMLSKPRIFHD
S572 NRASIVTSLRSGPLT
S575 SIVTSLRSGPLTVRV
Y611 LIVAAKYYFLRKAKA
Y651 SVETNSHYDSQNMDV
- gap
M656 SHYDSQNMDVEYTEV
Y660 SQNMDVEYTEVEVSS
T661 QNMDVEYTEVEVSSL
P670 VEVSSLEPHQENGRL
- gap
- gap
- gap
- gap
- gap
- gap
- gap
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