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Protein Page:
COX-2 (human)

Overview
COX-2 Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity. Homodimer. Belongs to the prostaglandin G/H synthase family. Note: This description may include information from UniProtKB.
Protein type: EC 1.14.99.1; Oxidoreductase; Lipid Metabolism - arachidonic acid
Cellular Component: endoplasmic reticulum membrane; neuron projection; protein complex; cytoplasm; nucleus
Molecular Function: prostaglandin-endoperoxide synthase activity; protein homodimerization activity; enzyme binding; peroxidase activity; arachidonate 15-lipoxygenase activity; metal ion binding; heme binding; lipid binding
Biological Process: positive regulation of nitric oxide biosynthetic process; positive regulation of apoptosis; positive regulation of smooth muscle cell proliferation; response to lithium ion; response to glucocorticoid stimulus; positive regulation of NF-kappaB import into nucleus; response to lipopolysaccharide; decidualization; prostaglandin biosynthetic process; sensory perception of pain; positive regulation of synaptic transmission, glutamatergic; negative regulation of synaptic transmission, dopaminergic; response to estradiol stimulus; bone mineralization; negative regulation of cell cycle; negative regulation of cell proliferation; response to vitamin D; lipoxygenase pathway; negative regulation of smooth muscle contraction; regulation of blood pressure; arachidonic acid metabolic process; positive regulation of smooth muscle contraction; angiogenesis; inflammatory response; response to fructose stimulus; positive regulation of prostaglandin biosynthetic process; response to drug; negative regulation of calcium ion transport; cyclooxygenase pathway; positive regulation of synaptic plasticity; learning; memory; prostaglandin metabolic process; response to manganese ion; ovulation; regulation of inflammatory response; positive regulation of vasoconstriction; brown fat cell differentiation; positive regulation of fever; response to oxidative stress; anagen; cell motility; embryo implantation
Reference #:  P35354 (UniProtKB)
Alt. Names/Synonyms: COX-2; COX2; cyclooxygenase 2b; Cyclooxygenase-2; GRIPGHS; hCox-2; PGG/HS; PGH synthase 2; PGH2; PGHS-2; PHS II; PHS-2; Prostaglandin G/H synthase 2; prostaglandin G/H synthase and cyclooxygenase; Prostaglandin H2 synthase 2; Prostaglandin-endoperoxide synthase 2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); PTGS2
Gene Symbols: PTGS2
Molecular weight: 68,996 Da
Basal Isoelectric point: 7.02  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

COX-2

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: Y446‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 Y120-p PPTYNADyGYKSWEA
0 1 Y248 QIIDGEMYPPTVKDT
0 1 S437 VQKVSQASIDQSRQM
1 1 Y446-p DQSRQMKyQSFNEYR
0 1 M457 NEYRKRFMLKPYESF
  mouse

 
Y120 PPTYNVHYGYKSWEA
Y248 QVIGGEVYPPTVKDT
S437-p VQAVAKAsIDQSREM
Y446-p DQSREMKyQSLNEYR
S457-p NEYRKRFsLKPYTSF
  rat

 
Y120 PPTYNVHYGYKSWEA
Y248-p QVIGGEVyPPTVKDT
S437 VQAVAKASIDQSREM
Y446 DQSREMKYQSLNEYR
S457 NEYRKRFSLKPYTSF
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