Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity. Homodimer. Belongs to the prostaglandin G/H synthase family. Note: This description may include information from UniProtKB.
Protein type: EC 126.96.36.199; Oxidoreductase; Lipid Metabolism - arachidonic acid
Molecular Function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; prostaglandin-endoperoxide synthase activity; enzyme binding; peroxidase activity; protein homodimerization activity; metal ion binding; heme binding; lipid binding
Biological Process: positive regulation of nitric oxide biosynthetic process; regulation of cell cycle; positive regulation of apoptosis; positive regulation of smooth muscle cell proliferation; response to glucocorticoid stimulus; response to lipopolysaccharide; decidualization; prostaglandin biosynthetic process; positive regulation of synaptic transmission, glutamatergic; negative regulation of synaptic transmission, dopaminergic; bone mineralization; response to estradiol stimulus; negative regulation of cell proliferation; response to vitamin D; regulation of blood pressure; positive regulation of smooth muscle contraction; inflammatory response; fatty acid biosynthetic process; response to fructose stimulus; positive regulation of prostaglandin biosynthetic process; response to drug; negative regulation of calcium ion transport; cyclooxygenase pathway; positive regulation of synaptic plasticity; response to organic nitrogen; memory; prostaglandin metabolic process; response to manganese ion; ovulation; response to cytokine stimulus; xenobiotic metabolic process; regulation of inflammatory response; positive regulation of vasoconstriction; positive regulation of fever; brown fat cell differentiation; response to oxidative stress; anagen; cell motility; embryo implantation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.