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COX-2 (human)

Overview COX-2 Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity. Homodimer. Belongs to the prostaglandin G/H synthase family. Note: This description may include information from UniProtKB. Protein type: Lipid Metabolism - arachidonic acid; Oxidoreductase; EC 1.14.99.1 Cellular Component: endoplasmic reticulum membrane; neuron projection; protein complex; endoplasmic reticulum lumen; cytoplasm; caveola; nucleus Molecular Function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; prostaglandin-endoperoxide synthase activity; peroxidase activity; protein homodimerization activity; enzyme binding; metal ion binding; heme binding; lipid binding Biological Process: positive regulation of nitric oxide biosynthetic process; regulation of cell cycle; positive regulation of apoptosis; positive regulation of smooth muscle cell proliferation; response to glucocorticoid stimulus; response to lipopolysaccharide; decidualization; prostaglandin biosynthetic process; positive regulation of synaptic transmission, glutamatergic; negative regulation of synaptic transmission, dopaminergic; response to estradiol stimulus; bone mineralization; negative regulation of cell proliferation; response to vitamin D; regulation of blood pressure; positive regulation of smooth muscle contraction; inflammatory response; fatty acid biosynthetic process; response to fructose stimulus; positive regulation of prostaglandin biosynthetic process; response to drug; negative regulation of calcium ion transport; cyclooxygenase pathway; positive regulation of synaptic plasticity; response to organic nitrogen; memory; prostaglandin metabolic process; ovulation; response to manganese ion; xenobiotic metabolic process; response to cytokine stimulus; regulation of inflammatory response; positive regulation of fever; brown fat cell differentiation; positive regulation of vasoconstriction; response to oxidative stress; anagen; cell motility; embryo implantation Reference #:  P35354 (UniProtKB) Alt. Names/Synonyms: COX-2; COX2; cyclooxygenase 2b; Cyclooxygenase-2; GRIPGHS; hCox-2; PGG/HS; PGH synthase 2; PGH2; PGHS-2; PHS II; PHS-2; Prostaglandin G/H synthase 2; prostaglandin G/H synthase and cyclooxygenase; Prostaglandin H2 synthase 2; Prostaglandin-endoperoxide synthase 2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); PTGS2 Gene Symbols: PTGS2 Molecular weight: 68,996 Da Basal Isoelectric point: 7.02  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below COX-2 1V0X - A=1-604 (human) 1CVU - A/B=18-569 (mouse) 1CX2 - A/B/C/D=18-604 (mouse) 1DCX - A/B=18-569 (mouse) 1DD0 - A/B=18-569 (mouse) 1DDX - A/B/C/D=18-569 (mouse) 1PXX - A/B/C/D=1-604 (mouse) 3HS5 - A/B=20-604 (mouse) 3HS6 - A/B=20-604 (mouse) 3HS7 - A/B=20-604 (mouse) 3KRK - A/B=20-604 (mouse) 3LN0 - A/D/C/B=18-604 (mouse) 3LN1 - A/D/C/B=18-604 (mouse) 3MDL - A/B=20-599 (mouse) 3MQE - A/D/C/B=18-604 (mouse) 3NTG - A/D/C/B=18-569 (mouse) 3OLT - A/B=20-604 (mouse) 3OLU - A/B=20-604 (mouse) 3PGH - A/B/C/D=18-604 (mouse) 3Q7D - A/B=18-604 (mouse) 3QH0 - A/B=1-604 (mouse) 3QMO - A/B=1-604 (mouse) 3RR3 - A/D/C/B=18-577 (mouse) 3TZI - A/B=19-604 (mouse) 4COX - A/B/C/D=18-604 (mouse) 4E1G - A/B=1-604 (mouse) 4FM5 - A/D/C/B=1-604 (mouse) 5COX - A/B/C/D=18-604 (mouse) 6COX - A/B=18-604 (mouse)

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y248	QIIDGEMYPPTVKDT
0	1		S437	VQKVSQASIDQSRQM
0	1		Y446	DQSRQMKYQSFNEYR
0	1		M457	NEYRKRFMLKPYESF

	mouse
Y248	QVIGGEVYPPTVKDT
S437-p	VQAVAKAsIDQSREM
Y446-p	DQSREMKyQSLNEYR
S457-p	NEYRKRFsLKPYTSF

	rat
Y248-p	QVIGGEVyPPTVKDT
S437	VQAVAKASIDQSREM
Y446	DQSREMKYQSLNEYR
S457	NEYRKRFSLKPYTSF

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