Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity. Homodimer. Belongs to the prostaglandin G/H synthase family. Note: This description may include information from UniProtKB.
Protein type: Lipid Metabolism - arachidonic acid; Oxidoreductase; EC 188.8.131.52
Molecular Function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; prostaglandin-endoperoxide synthase activity; peroxidase activity; enzyme binding; protein homodimerization activity; dioxygenase activity; metal ion binding; heme binding; oxidoreductase activity; lipid binding
Biological Process: positive regulation of nitric oxide biosynthetic process; positive regulation of apoptosis; positive regulation of smooth muscle cell proliferation; response to lipopolysaccharide; positive regulation of NF-kappaB import into nucleus; decidualization; sensory perception of pain; prostaglandin biosynthetic process; fatty acid metabolic process; negative regulation of synaptic transmission, dopaminergic; positive regulation of synaptic transmission, glutamatergic; bone mineralization; negative regulation of cell cycle; negative regulation of cell proliferation; negative regulation of smooth muscle contraction; regulation of blood pressure; positive regulation of cell proliferation; positive regulation of smooth muscle contraction; angiogenesis; inflammatory response; fatty acid biosynthetic process; negative regulation of calcium ion transport; cyclooxygenase pathway; positive regulation of synaptic plasticity; learning; memory; regulation of cell proliferation; prostaglandin metabolic process; ovulation; keratinocyte differentiation; response to cytokine stimulus; positive regulation of fever; brown fat cell differentiation; positive regulation of vasoconstriction; response to oxidative stress; lipid metabolic process; anagen; embryo implantation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.