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MAS1 (human)

Overview MAS1 Receptor for angiotensin 1-7. Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB. Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Oncoprotein Cellular Component: cell surface; integral to plasma membrane; plasma membrane Molecular Function: G-protein coupled receptor activity; angiotensin type II receptor activity; peptide hormone binding; peptide binding; angiotensin receptor activity Biological Process: response to drug; anatomical structure morphogenesis; male gonad development; hippocampus development; activation of NF-kappaB-inducing kinase; cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of protein amino acid phosphorylation; regulation of inflammatory response; positive regulation of cell proliferation; spermatogenesis; response to activity; positive regulation of DNA replication Reference #:  P04201 (UniProtKB) Alt. Names/Synonyms: MAS; MAS1; MAS1 oncogene; MGC119966; Proto-oncogene Mas Gene Symbols: MAS1 Molecular weight: 37,465 Da Basal Isoelectric point: 8.9  Predict pI for various phosphorylation states

Select Structure to View Below MAS1

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T104	LSSGHYYTIVTLSVT
0	1		T107	GHYYTIVTLSVTFLF
0	1		Y121-p	FGYNTGLyLLTAISV

	mouse
T103-p	LSSGHHYtIVtLSVT
T106-p	GHHYtIVtLSVTFLF
Y120	FGYNTGLYLLTAISV

	rat
T103	LSSGHYYTIVTLSVT
T106	GHYYTIVTLSVTFLF
Y120	FGYNTGLYLLTAISV

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