Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
SDH5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SDH5 a subunit of succinate dehydrogenase (SDH) complex II of the mitochondrial electron transport chain. SDH5 is required for insertion of FAD cofactor into SDHA, the catalytic subunit of succinate dehydrogenase (SDH) complex II. SDH is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Mutated in some cancers. Germline mutations cause hereditary paragangliomas type 2, or non-chromaffin paragangliomas type 2. Paragangliomas are rare tumors that arise from components of the neuroendocrine system. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 11q12.2
Cellular Component: mitochondrion
Molecular Function: protein binding
Biological Process: mitochondrial electron transport, succinate to ubiquinone; protein-FAD linkage; protein amino acid dephosphorylation
Reference #:  Q9NX18 (UniProtKB)
Alt. Names/Synonyms: C11orf79; FLJ20487; hSDH5; paraganglioma or familial glomus tumors 2; PGL2; SDH assembly factor 2; SDH5; SDHAF2; SDHF2; Succinate dehydrogenase assembly factor 2, mitochondrial; succinate dehydrogenase complex assembly factor 2; Succinate dehydrogenase subunit 5, mitochondrial
Gene Symbols: SDHAF2
Molecular weight: 19,599 Da
Basal Isoelectric point: 6.33  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SDH5

Protein Structure Not Found.


STRING  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S20 MLALSRHSLLSPLLs
0 1 S27-p SLLSPLLsVtsFRRF
0 1 T29-p LSPLLsVtsFRRFYR
0 1 S30-p SPLLsVtsFRRFYRG
0 1 K66-ub TDESIETkRARLLYE
0 1 K100-ub HLQHMTEkQLNLYDR
0 1 K164-ub DLEYLFEkPR_____
  mouse

 
S18-p ARALSKHsLLSPLPS
S25 sLLSPLPSVTSFRRF
T27 LSPLPSVTSFRRFYR
S28 SPLPSVTSFRRFYRG
K64 TDESIETKRARLLYE
K98 YLHNMTEKQLNLYDR
K162 DLEYLFEKPH_____
  rat

 
S18 ARVLSKHSLLSPLLS
S25 SLLSPLLSVTSFRRF
T27 LSPLLSVTSFRRFYR
S28 SPLLSVTSFRRFYRG
K64 TDESIETKRARLLYE
K98 YLHNMTEKQLNLYDR
K162 DLEYLFEKPR_____
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.