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Protein Page:
DDX4 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
DDX4 May play a role in germ cell development. May play a role in sperm motility. Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. N-terminus interacts with RANBP9. Interacts with PIWIL2 and MAEL. Expressed only in ovary and testis. Expressed in migratory primordial germ cells in the region of the gonadal ridge in both sexes. Belongs to the DEAD box helicase family. DDX4/VASA subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.13; EC 3.6.1.-; Helicase
Cellular Component: perinuclear region of cytoplasm; cytoplasm; nucleus
Molecular Function: nucleic acid binding; ATP-dependent helicase activity; ATP binding
Biological Process: sperm motility; regulation of protein localization; male meiosis I; multicellular organismal development; spermatogenesis
Reference #:  Q9NQI0 (UniProtKB)
Alt. Names/Synonyms: DDX4; DEAD (Asp-Glu-Ala-Asp) box polypeptide 4; DEAD box protein 4; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 4; MGC111074; Probable ATP-dependent RNA helicase DDX4; VASA; Vasa homolog
Gene Symbols: DDX4
Molecular weight: 79,308 Da
Basal Isoelectric point: 5.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DDX4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 S139-p GYRDGNNsEASGPYR
0 2 R177 DPDECMQRTGGLFGS
0 2 R185 TGGLFGSRRPVLSGT
0 1 T220 GLNEEVITGSGKNSW
0 1 S226 ITGSGKNSWKSEAEG
0 1 S229 SGKNSWKSEAEGGES
0 1 A231 KNSWKSEAEGGESSD
1 1 K432-a RLMDIIGkEKIGLKQ
0 1 K530-a GQFSKREkLVEILRN
0 1 S722 PNPVDDESWD_____
  DDX4 iso3  
- gap
R44 DPDECMQRTGGLFGS
R52 TGGLFGSRRPVLSGT
- gap
S77 GSGSERDSWKSEAEG
S80 SERDSWKSEAEGGES
A82 RDSWKSEAEGGESSD
K283 RLMDIIGKEKIGLKQ
K381 GQFSKREKLVEILRN
S573 PNPVDDESWD_____
  mouse

► Hide Isoforms
 
S114-p GCQDGNDsEASGPFR
R152-m1 DQDQGTQrGGGLFGS
R160-m1 GGGLFGSrKPAASDS
T193-p GLNEEVVtGSGKNsW
S199-p VtGSGKNsWKsEtEG
S202-p SGKNsWKsEtEGGES
T204-p KNsWKsEtEGGESSD
K405-a RLMDIIGkEKIGLKQ
K503 GQYSKREKLVEILRN
S700-p PNPVDDEsWD_____
  DDX4 iso3  
S140 GCQDGNDSEASGPFR
R178 DQDQGTQRGGGLFGS
R186 GGGLFGSRKPAASDS
T219 GLNEEVVTGSGKNSW
S225 VTGSGKNSWKSETEG
S228 SGKNSWKSETEGGES
T230 KNSWKSETEGGESSD
K431 RLMDIIGKEKIGLKQ
K529 GQYSKREKLVEILRN
S726 PNPVDDESWD_____
  rat

 
S141 GYPDGNDSEASGPFR
R164 DQDQGSQRGGGLFGS
R172 GGGLFGSRKPAASDS
T205 GLNEEVVTGSGKNSW
S211 VTGSGKNSWKSEAEG
S214 SGKNSWKSEAEGGES
A216 KNSWKSEAEGGESSD
K417 RLMDIIGKEKIGLKQ
K515 GPVFKKRKLVEILRN
S711 PNPVDDESWD_____
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