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Protein Page:
DDX4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DDX4 May play a role in germ cell development. May play a role in sperm motility. Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. N-terminus interacts with RANBP9. Interacts with PIWIL2 and MAEL. Expressed only in ovary and testis. Expressed in migratory primordial germ cells in the region of the gonadal ridge in both sexes. Belongs to the DEAD box helicase family. DDX4/VASA subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Helicase; EC 3.6.1.-; EC 3.6.4.13
Cellular Component: perinuclear region of cytoplasm; cytoplasm; nucleus
Molecular Function: nucleic acid binding; ATP-dependent helicase activity; ATP binding
Biological Process: ATP catabolic process; sperm motility; regulation of protein localization; male meiosis I; multicellular organismal development; spermatogenesis
Reference #:  Q9NQI0 (UniProtKB)
Alt. Names/Synonyms: DDX4; DEAD (Asp-Glu-Ala-Asp) box polypeptide 4; DEAD box protein 4; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 4; MGC111074; Probable ATP-dependent RNA helicase DDX4; VASA; Vasa homolog
Gene Symbols: DDX4
Molecular weight: 79,308 Da
Basal Isoelectric point: 5.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DDX4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T37-p NGDNFNRtPASSSEM
0 1 N64 SGFASGRNFGNRDAG
0 1 N67 ASGRNFGNRDAGECN
0 1 C73 GNRDAGECNkRDNTS
0 1 N74 NRDAGECNkRDNTST
0 1 K75-ac RDAGECNkRDNTSTM
0 1 K89-ac MGGFGVGksFGNRGF
0 1 S90-p GGFGVGksFGNRGFS
0 1 - gap
0 1 - gap
0 1 R130 RNRGFSKRGGyRDGN
0 1 Y133-p GFSKRGGyRDGNNsE
0 2 S139-p GyRDGNNsEASGPYR
0 1 S142 DGNNsEASGPYRRGG
0 2 R177 DPDECMQRTGGLFGS
0 2 R185 TGGLFGSRRPVLSGT
0 1 T220 GLNEEVITGSGKNSW
0 2 S226 ITGSGKNSWKSEAEG
0 2 S229 SGKNSWKSEAEGGES
0 1 A231 KNSWKSEAEGGESSD
0 1 T312-p KAGYTKLtPVQKYSI
0 1 T339-p AQTGSGKtAAFLLPI
1 1 K432-ac RLMDIIGkEKIGLKQ
0 1 Y442-p IGLKQIKyLVLDEAD
0 1 K462 GFGPEMKKLISCPGM
0 1 K530-ac GQFSKREkLVEILRN
0 1 S722 PNPVDDESWD_____
  DDX4 iso3  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S11-p RNLFLTNsPEsSNDC
S14-p FLTNsPEsSNDCEDN
R31 RNRGFSKRGDNDLDP
- gap
- gap
- gap
R44 DPDECMQRTGGLFGS
R52 TGGLFGSRRPVLSGT
- gap
S77-p GSGSERDsWKsEAEG
S80-p SERDsWKsEAEGGES
A82 RDsWKsEAEGGESSD
T163 KAGYTKLTPVQKYSI
T190 AQTGSGKTAAFLLPI
K283 RLMDIIGKEKIGLKQ
Y293 IGLKQIKYLVLDEAD
K313 GFGPEMKKLISCPGM
K381 GQFSKREKLVEILRN
S573 PNPVDDESWD_____
  mouse

► Hide Isoforms
 
T39 NGDTFNRTSASSDIG
- gap
- gap
S48 ASSDIGESSKKENTS
S49 SSDIGESSKKENTST
K50 SDIGESSKKENTSTT
K64 TGGFGRGKGFGNRGF
G65 GGFGRGKGFGNRGFL
- gap
- gap
R105-m1 RSRGFSKrGGCQDGN
C108 GFSKrGGCQDGNDsE
S114-p GCQDGNDsEAsGPFR
S117-p DGNDsEAsGPFRRGG
R152-m1 DQDQGTQrGGGLFGS
R160-m1 GGGLFGSrKPAASDS
T193-p GLNEEVVtGSGKNsW
S199-p VtGSGKNsWKsEtEG
S202-p SGKNsWKsEtEGGES
T204-p KNsWKsEtEGGESSD
T285 KAGYTKLTPVQKYSI
T312 AQTGSGKTAAFLLPI
K405-ac RLMDIIGkEKIGLKQ
Y415 IGLKQVKYLVLDEAD
K435-ac GFGPEMKkLISCPGM
K503 GQYSKREKLVEILRN
S700-p PNPVDDEsWD_____
  DDX4 iso3  
T39 NGDTFNRTSASSEME
S65-p SGFPSGRsLGsRDIG
S68-p PSGRsLGsRDIGEss
S74-p GsRDIGEssKKENTS
S75-p sRDIGEssKKENTST
K76 RDIGEssKKENTSTT
K90 TGGFGRGKGFGNRGF
G91 GGFGRGKGFGNRGFL
- gap
- gap
R131 RSRGFSKRGGCQDGN
C134 GFSKRGGCQDGNDSE
S140 GCQDGNDSEASGPFR
S143 DGNDSEASGPFRRGG
R178 DQDQGTQRGGGLFGS
R186 GGGLFGSRKPAASDS
T219 GLNEEVVTGSGKNSW
S225 VTGSGKNSWKSETEG
S228 SGKNSWKSETEGGES
T230 KNSWKSETEGGESSD
T311 KAGYTKLTPVQKYSI
T338 AQTGSGKTAAFLLPI
K431 RLMDIIGKEKIGLKQ
Y441 IGLKQVKYLVLDEAD
K461 GFGPEMKKLISCPGM
K529 GQYSKREKLVEILRN
S726 PNPVDDESWD_____
  rat

 
T39 NGDTFNRTSASSSEM
N66 SGFSSGRNLGNRDIG
N69 SSGRNLGNRDIGESS
S75 GNRDIGESSKRETTS
S76 NRDIGESSKRETTST
K77 RDIGESSKRETTSTT
K91 TGGFGRGKGFGNRGF
G92 GGFGRGKGFGNRGFL
- gap
- gap
R132 RSRGFSKRGGYPDGN
Y135 GFSKRGGYPDGNDSE
S141 GYPDGNDSEASGPFR
S144 DGNDSEASGPFRRGG
R164 DQDQGSQRGGGLFGS
R172 GGGLFGSRKPAASDS
T205 GLNEEVVTGSGKNSW
S211 VTGSGKNSWKSEAEG
S214 SGKNSWKSEAEGGES
A216 KNSWKSEAEGGESSD
T297 KAGYTKLTPVQKYSI
T324 AQTGSGKTAAFLLPI
K417 RLMDIIGKEKIGLKQ
Y427 IGLKQVKYLVLDEAD
K447 GFGPEMKKLISCPGM
K515 GPVFKKRKLVEILRN
S711 PNPVDDESWD_____
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