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GABRR1 (human)

Overview GABRR1 GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR1 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Channel, chloride; Membrane protein, integral; Channel, ligand-gated; Receptor, misc. Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction Molecular Function: protein domain specific binding; chloride channel activity; GABA-A receptor activity; protein homodimerization activity; protein heterodimerization activity; extracellular ligand-gated ion channel activity Biological Process: synaptic transmission; transport; transmembrane transport; gamma-aminobutyric acid signaling pathway Reference #:  P24046 (UniProtKB) Alt. Names/Synonyms: bA135P14.1 (gamma-aminobutyric acid (GABA) receptor, rho 1); GABA(A) receptor subunit rho-1; GABRR1; gamma-aminobutyric acid (GABA) A receptor, rho-1; gamma-aminobutyric acid (GABA) receptor, rho 1; Gamma-aminobutyric acid receptor subunit rho-1; GBRR1; MGC163216 Gene Symbols: GABRR1 Molecular weight: 55,883 Da Basal Isoelectric point: 8.71  Predict pI for various phosphorylation states

Select Structure to View Below GABRR1

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S166-p	FFVHSKRsFIHDttT
0	1		T171-p	KRsFIHDttTDNVML
0	1		T172-p	RsFIHDttTDNVMLR
0	1		Y219-p	CSLEIESyAyTEDDL
0	1		Y221-p	LEIESyAyTEDDLML
0	1		Y229-p	TEDDLMLyWKKGNDS
1	0		T326	TTVLTMSTIITGVNA
1	0		S334	IITGVNASMPRVSYI
0	1		Y401	TAMLDGNYSDGEVND
0	1		Y412	EVNDLDNYMPENGEK

	mouse
S167	FFVHSKRSFIHDTTT
T172	KRSFIHDTTTDNVML
T173	RSFIHDTTTDNVMLR
Y220	CSLEIESYAYTEDDL
Y222	LEIESYAYTEDDLML
Y230	TEDDLMLYWKKGNDS
T327-p	TTVLTMStIITGVNA
S335-p	IITGVNAsMPRVSYI
Y402	GVMLDSSYSDGEVND
Y413	EVNDLGGYMPENGEK

	rat
S167	FFVHSKRSFIHDTTT
T172	KRSFIHDTTTDNVML
T173	RSFIHDTTTDNVMLR
Y220	CSLEIESYAYTEDDL
Y222	LEIESYAYTEDDLML
Y230	TEDDLMLYWKKGNDS
T327	TTVLTMSTIITGVNA
S335	IITGVNASMPRVSYI
Y402-p	GVMLDSSySDGEVND
Y413-p	EVNDLGGyMPENGEK

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