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Protein Page:
ARTS1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ARTS1 Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. Belongs to the peptidase M1 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protease; EC 3.4.11.-; Membrane protein, integral
Cellular Component: extracellular space; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; endoplasmic reticulum lumen; extracellular region; integral to membrane; cytosol
Molecular Function: protein binding; interleukin-6 receptor binding; metalloexopeptidase activity; interleukin-1, Type II receptor binding; zinc ion binding; aminopeptidase activity
Biological Process: fat cell differentiation; positive regulation of angiogenesis; antigen processing and presentation of peptide antigen via MHC class I; response to bacterium; regulation of blood pressure; membrane protein ectodomain proteolysis; angiogenesis; antigen processing and presentation of endogenous peptide antigen via MHC class I; regulation of innate immune response
Reference #:  Q9NZ08 (UniProtKB)
Alt. Names/Synonyms: A-LAP; Adipocyte-derived leucine aminopeptidase; ALAP; Aminopeptidase PILS; aminopeptidase regulator of TNFR1 shedding; APPILS; ARTS-1; ARTS1; Endoplasmic reticulum aminopeptidase 1; ERAAP; ERAAP1; ERAP1; KIAA0525; PILS-AP; PILSAP; Puromycin-insensitive leucyl-specific aminopeptidase; Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator
Gene Symbols: ERAP1
Molecular weight: 107,235 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
Select Structure to View Below

ARTS1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S179-p GELRILAsTQFEPtA
0 2 T185-p AsTQFEPtAARMAFP
0 1 S217 EPRHLAISNMPLVKS
0 1 S268-p TKSGVKVsVyAVPDK
0 2 Y270-p SGVKVsVyAVPDKIN
0 1 Y399-p PELKVGDyFFGKCFD
0 1 Y451 ILNMLREYLSADAFK
0 1 Y464-p FKSGIVQyLQKHSYK
0 1 H468 IVQyLQKHSYKNtKN
0 1 Y470 QyLQKHSYKNtKNED
0 1 T473-p QKHSYKNtKNEDLWD
0 1 Y608-p NVGMNGYyIVHYEDD
0 1 K811-ac ALCRTQNkEKLQWLL
0 1 K899 KGFFSSLKENGSQLR
  mouse

 
A168 GEMRILAATQFEPTA
T174 AATQFEPTAARMAFP
S206-p DPRHLAIsNMPLVKS
S257 TKSGVKVSVYAVPDK
Y259 SGVKVSVYAVPDKIN
Y388 PELKVEDYFFGKCFN
Y440 ILNMLRDYLSADTFK
Y453 FKRGIVQYLQKYSYK
Y457 IVQYLQKYSYKNTKN
Y459 QYLQKYSYKNTKNED
T462 QKYSYKNTKNEDLWN
Y597 NVGMNGYYIVHYADD
P800 SLCTSKDPEKLQWLL
K888-ub KGFFSSLkENGSQLR
  rat

 
A168 GERRILAATQFEPTA
T174 AATQFEPTAARMAFP
S206 DPRHLAISNMPLVKS
S257 TKSGVKVSVYAVPDK
Y259 SGVKVSVYAVPDKIN
Y388 PELKVEEYFFGKCFN
Y440-p ILNMLRDyLSADTFK
Y453 FKRGIVQYLQKySyK
Y457-p IVQYLQKySyKNTKN
Y459-p QYLQKySyKNTKNED
T462 QKySyKNTKNEDLWN
Y597 NVGMNGYYIVHYGDD
P800 SLCISQDPEKLQWLL
K888 KGFFSSLKKNGSQLR
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