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Protein Page:
FOXG1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FOXG1 Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. Interacts with KDM5B. Expression is restricted to the neurons of the developing telencephalon. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Cellular Component: nucleus
Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; transcription factor activity
Biological Process: neuron fate determination; positive regulation of neuroblast proliferation; inner ear morphogenesis; transcription, DNA-dependent; pyramidal neuron migration; regulation of mitotic cell cycle; positive regulation of cell cycle; axon midline choice point recognition; negative regulation of neuron differentiation; dorsal/ventral pattern formation; brain development; negative regulation of transcription, DNA-dependent; aging
Reference #:  P55316 (UniProtKB)
Alt. Names/Synonyms: BF-1; BF-2; BF1; BF2; Brain factor 1; Brain factor 2; FHKL3; FKH2; FKHL1; FKHL2; FKHL3; FKHL4; forkhead box G1; forkhead box G1A; forkhead box G1B; forkhead box G1C; Forkhead box protein G1; Forkhead box protein G1A; Forkhead box protein G1B; Forkhead box protein G1C; forkhead, drosophila, homolog-like 2; forkhead-like 1; forkhead-like 2; forkhead-like 3; forkhead-like 4; Forkhead-related protein FKHL1; Forkhead-related protein FKHL2; Forkhead-related protein FKHL3; FOXG1; FOXG1A; FOXG1B; FOXG1C; HBF-1; hBF-2; HBF-3; HBF-G2; HBF2; HFK1; HFK2; HFK3; KHL2; oncogene QIN; QIN
Gene Symbols: FOXG1
Molecular weight: 52,352 Da
Basal Isoelectric point: 8.99  Predict pI for various phosphorylation states
Select Structure to View Below

FOXG1

Protein Structure Not Found.


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Sites Implicated In
cell differentiation, altered: S19‑p
intracellular localization: S19‑p, T279‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K11-ac MGDRKEVkMIPKSSF
1 0 S19-p MIPKSSFsINSLVPE
0 1 Y186-p YEKPPFSyNALIMMA
0 1 Y208-p RLTLNGIyEFIMKNF
0 1 Y246-p FVKVPRHyDDPGKGN
0 1 Y254-p DDPGKGNyWMLDPSS
0 2 S277-p TGKLRRRsttsRAKL
0 1 T278-p GKLRRRsttsRAKLA
2 0 T279-p KLRRRsttsRAKLAF
0 1 S280-p LRRRsttsRAKLAFK
  mouse

 
K11 MGDRKEVKMIPKSSF
S19 MIPKSSFSINSLVPE
Y178 YEKPPFSYNALIMMA
Y200 RLTLNGIYEFIMKNF
Y238 FVKVPRHYDDPGKGN
Y246 DDPGKGNYWMLDPSS
S269 TGKLRRRSTtSRAKL
T270 GKLRRRSTtSRAKLA
T271-p KLRRRSTtSRAKLAF
S272 LRRRSTtSRAKLAFK
  rat

 
K11 MGDRKEVKMIPKSSF
S19 MIPKSSFSINSLVPE
Y177 YEKPPFSYNALIMMA
Y199-p RLTLNGIyEFIMKNF
Y237 FVKVPRHYDDPGKGN
Y245 DDPGKGNYWMLDPSS
S268 TGKLRRRSTTSRAKL
T269 GKLRRRSTTSRAKLA
T270 KLRRRSTTSRAKLAF
S271 LRRRSTTSRAKLAFK
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