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FOXG1 (human)

Overview FOXG1 Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. Interacts with KDM5B. Expression is restricted to the neurons of the developing telencephalon. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Transcription factor Cellular Component: transcription factor complex; nucleus Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; DNA binding; sequence-specific DNA binding; double-stranded DNA binding; DNA bending activity; transcription factor binding Biological Process: tissue development; positive regulation of neuroblast proliferation; inner ear morphogenesis; regulation of mitotic cell cycle; positive regulation of cell cycle; axon midline choice point recognition; embryonic development ending in birth or egg hatching; negative regulation of neuron differentiation; regulation of transcription factor activity; dorsal/ventral pattern formation; regulation of transcription, DNA-dependent; sensory cilium biogenesis; forebrain development; positive regulation of transcription from RNA polymerase II promoter; brain development; negative regulation of transcription, DNA-dependent; nose development; central nervous system neuron development; hindbrain development Reference #:  P55316 (UniProtKB) Alt. Names/Synonyms: BF-1; BF-2; BF1; BF2; Brain factor 1; Brain factor 2; FHKL3; FKH2; FKHL1; FKHL2; FKHL3; FKHL4; forkhead box G1; forkhead box G1A; forkhead box G1B; forkhead box G1C; Forkhead box protein G1; Forkhead box protein G1A; Forkhead box protein G1B; Forkhead box protein G1C; forkhead, drosophila, homolog-like 2; forkhead-like 1; forkhead-like 2; forkhead-like 3; forkhead-like 4; Forkhead-related protein FKHL1; Forkhead-related protein FKHL2; Forkhead-related protein FKHL3; FOXG1; FOXG1A; FOXG1B; FOXG1C; HBF-1; hBF-2; HBF-3; HBF-G2; HBF2; HFK1; HFK2; HFK3; KHL2; oncogene QIN; QIN Gene Symbols: FOXG1 Molecular weight: 52,352 Da Basal Isoelectric point: 8.99  Predict pI for various phosphorylation states

Select Structure to View Below FOXG1

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 164874 600779 605524  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell differentiation, altered: S19‑p intracellular localization: S19‑p, T279‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K11-a	MGDRKEVkMIPKSSF
1	0		S19-p	MIPKSSFsINSLVPE
0	1		Y186-p	YEKPPFSyNALIMMA
0	3		Y208-p	RLTLNGIyEFIMKNF
0	2		S277-p	TGKLRRRsttsRAKL
0	1		T278-p	GKLRRRsttsRAKLA
2	0		T279-p	KLRRRsttsRAKLAF
0	1		S280-p	LRRRsttsRAKLAFK

	mouse
K11	MGDRKEVKMIPKSSF
S19	MIPKSSFSINSLVPE
Y178	YEKPPFSYNALIMMA
Y200	RLTLNGIYEFIMKNF
S269	TGKLRRRSTtSRAKL
T270	GKLRRRSTtSRAKLA
T271-p	KLRRRSTtSRAKLAF
S272	LRRRSTtSRAKLAFK

	rat
K11	MGDRKEVKMIPKSSF
S19	MIPKSSFSINSLVPE
Y177	YEKPPFSYNALIMMA
Y199-p	RLTLNGIyEFIMKNF
S268	TGKLRRRSTTSRAKL
T269	GKLRRRSTTSRAKLA
T270	KLRRRSTTSRAKLAF
S271	LRRRSTTSRAKLAFK

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