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Protein Page:
FOXG1 (human)

Overview
FOXG1 Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. Interacts with KDM5B. Expression is restricted to the neurons of the developing telencephalon. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: nucleus
Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; transcription factor activity
Biological Process: neuron fate determination; positive regulation of neuroblast proliferation; inner ear morphogenesis; negative regulation of neuron differentiation; dorsal/ventral pattern formation; transcription, DNA-dependent; pyramidal neuron migration; regulation of mitotic cell cycle; positive regulation of cell cycle; brain development; negative regulation of transcription, DNA-dependent; axon midline choice point recognition; aging
Reference #:  P55316 (UniProtKB)
Alt. Names/Synonyms: BF-1; BF-2; BF1; BF2; Brain factor 1; Brain factor 2; FHKL3; FKH2; FKHL1; FKHL2; FKHL3; FKHL4; forkhead box G1; forkhead box G1A; forkhead box G1B; forkhead box G1C; Forkhead box protein G1; Forkhead box protein G1A; Forkhead box protein G1B; Forkhead box protein G1C; forkhead, drosophila, homolog-like 2; forkhead-like 1; forkhead-like 2; forkhead-like 3; forkhead-like 4; Forkhead-related protein FKHL1; Forkhead-related protein FKHL2; Forkhead-related protein FKHL3; FOXG1; FOXG1A; FOXG1B; FOXG1C; HBF-1; hBF-2; HBF-3; HBF-G2; HBF2; HFK1; HFK2; HFK3; KHL2; oncogene QIN; QIN
Gene Symbols: FOXG1
Molecular weight: 52,352 Da
Basal Isoelectric point: 8.99  Predict pI for various phosphorylation states
Select Structure to View Below

FOXG1

Protein Structure Not Found.


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Sites Implicated In
cell differentiation, altered: S19‑p
intracellular localization: S19‑p, T279‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S19-p MIPKSSFsINSLVPE
0 2 Y208-p RLTLNGIyEFIMKNF
0 2 S277-p TGKLRRRsTtSRAKL
2 0 T279-p KLRRRsTtSRAKLAF
  mouse

 
S19 MIPKSSFSINSLVPE
Y200 RLTLNGIYEFIMKNF
S269 TGKLRRRSTtSRAKL
T271-p KLRRRSTtSRAKLAF
  rat

 
S19 MIPKSSFSINSLVPE
Y199-p RLTLNGIyEFIMKNF
S268 TGKLRRRSTTSRAKL
T270 KLRRRSTTSRAKLAF
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