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IGFBP2 (human)

Overview IGFBP2 Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Binds IGF2 more than IGF1. Note: This description may include information from UniProtKB. Protein type: Secreted, signal peptide; Secreted Cellular Component: extracellular space; apical plasma membrane; extracellular region; cytoplasmic vesicle Molecular Function: protein binding; insulin-like growth factor I binding; insulin-like growth factor II binding Biological Process: response to drug; response to retinoic acid; regulation of insulin-like growth factor receptor signaling pathway; response to lithium ion; response to glucocorticoid stimulus; female pregnancy; signal transduction; positive regulation of activated T cell proliferation; response to estradiol stimulus; cellular response to hormone stimulus; response to mechanical stimulus; response to stress; regulation of cell growth; aging Reference #:  P18065 (UniProtKB) Alt. Names/Synonyms: BP2; IBP-2; IBP2; IGF-binding protein 2; IGF-BP53; IGFBP-2; IGFBP2; insulin-like growth factor binding protein 2, 36kDa; Insulin-like growth factor-binding protein 2 Gene Symbols: IGFBP2 Molecular weight: 34,814 Da Basal Isoelectric point: 7.48  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below IGFBP2 2H7T - A=223-328 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		Y112	CGQGLRCYPHPGSEL
1	1		S142-p	RDAEYGAsPEQVADN
0	1		K186	KPLKSGMKELAVFRE
0	1		T196-p	AVFREKVtEQHRQMG
0	1		K207-a	RQMGKGGkHHLGLEE

	mouse
Y96	CAQTLRCYPNPGSEL
T123	EKRRVGTTPQQVADS
K167-u	KPLKSGMkELAVFRE
N177	AVFREKVNEQHRQMG
K188	RQMGKGAKHLSLEEP

	rat
Y96-p	CAQTLRCyPNPGSEL
T123	EKRRVGATPQQVADS
K166	KPPKSGMKELAVFRE
N176	AVFREKVNEQHRQMG
K187	RQMGKGAKHLSLEEP

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