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Protein Page:
IGFBP2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IGFBP2 Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Binds IGF2 more than IGF1. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted
Cellular Component: extracellular space; apical plasma membrane; extracellular region; cytoplasmic vesicle
Molecular Function: protein binding; insulin-like growth factor I binding; insulin-like growth factor II binding
Biological Process: response to drug; regulation of insulin-like growth factor receptor signaling pathway; response to retinoic acid; response to lithium ion; response to glucocorticoid stimulus; female pregnancy; signal transduction; positive regulation of activated T cell proliferation; response to estradiol stimulus; cellular response to hormone stimulus; cellular protein metabolic process; response to mechanical stimulus; regulation of cell growth; response to nutrient; aging
Reference #:  P18065 (UniProtKB)
Alt. Names/Synonyms: BP2; IBP-2; IBP2; IGF-binding protein 2; IGF-BP53; IGFBP-2; IGFBP2; insulin-like growth factor binding protein 2, 36kDa; Insulin-like growth factor-binding protein 2
Gene Symbols: IGFBP2
Molecular weight: 34,814 Da
Basal Isoelectric point: 7.48  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IGFBP2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y112 CGQGLRCYPHPGSEL
1 1 S142-p RDAEYGAsPEQVADN
0 1 K186 KPLKSGMKELAVFRE
0 1 T196-p AVFREKVtEQHRQMG
0 1 K207-ac RQMGKGGkHHLGLEE
0 1 T299-p KLIQGAPtIRGDPEC
  mouse

 
Y96 CAQTLRCYPNPGSEL
T123 EKRRVGTTPQQVADS
K167-ub KPLKSGMkELAVFRE
N177 AVFREKVNEQHRQMG
K188 RQMGKGAKHLSLEEP
T279 KPIQGAPTIRGDPEC
  rat

 
Y96-p CAQTLRCyPNPGSEL
T123 EKRRVGATPQQVADS
K166 KPPKSGMKELAVFRE
N176 AVFREKVNEQHRQMG
K187 RQMGKGAKHLSLEEP
T278 KPIQGAPTIRGDPEC
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