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Protein Page:
XRCC3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
XRCC3 Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C. Defects in XRCC3 are the cause of susceptibility to breast cancer (BC). BC is a common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. Defects in XRCC3 are the cause of susceptibility to cutaneous malignant melanoma type 6 (CMM6). CMM6 is a malignant neoplasm of melanocytes, arising de novo or from a pre- existing benign nevus, which occurs most often in the skin but also may involve other sites. Belongs to the RecA family. RAD51 subfamily. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 14q32.3
Cellular Component: mitochondrion; perinuclear region of cytoplasm; cytoplasm; replication fork; nucleus
Molecular Function: DNA-dependent ATPase activity; protein binding; four-way junction DNA binding; crossover junction endodeoxyribonuclease activity; ATP binding
Biological Process: response to organic substance; ATP catabolic process; DNA repair; response to DNA damage stimulus; DNA catabolic process, endonucleolytic; double-strand break repair via homologous recombination; DNA recombination
Reference #:  O43542 (UniProtKB)
Alt. Names/Synonyms: DNA repair protein XRCC3; RAD51-like; X-ray repair complementing defective repair in Chinese hamster cells 3; X-ray repair cross complementing protein 3; X-ray repair cross-complementing protein 3; XRCC3
Gene Symbols: XRCC3
Molecular weight: 37,850 Da
Basal Isoelectric point: 8.81  Predict pI for various phosphorylation states
Select Structure to View Below

XRCC3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S23-p IKKAKLKsVKEVLHF
0 1 T163 AQQPRLRTDVPGELL
0 1 K172-ub VPGELLQkLRFGsQI
0 2 S177-p LQkLRFGsQIFIEHV
0 1 T189-p EHVADVDtLLECVNK
1 1 S225-p PFRCEFDsQASAPRA
0 1 T241-p HLQSLGAtLRELSSA
  mouse

 
S23 VKRGRLKSVKEILCY
T163-p AQQRRLRtDAPEELI
K172 APEELIEKIRFSNHI
N177 IEKIRFSNHIFIEHA
T189 EHAADVDTLLECVSK
L225 PFRCEFHLQASAIRA
T241 LLLSLGATLRRLSST
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