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Protein Page:
SLC26A3 (human)

Overview
SLC26A3 Chloride/bicarbonate exchanger. Mediates the efficient absorbtion of chloride ions in the colon, participating in fluid homeostasis. Defects in SLC26A3 are the cause of diarrhea type 1 (DIAR1); also known as congenital chloride diarrhea (CLD). DIAR1 is a disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. Note: This description may include information from UniProtKB.
Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family
Cellular Component: membrane; brush border membrane; apical plasma membrane; plasma membrane; integral to membrane
Molecular Function: bicarbonate transmembrane transporter activity; protein binding; chloride transmembrane transporter activity; transporter activity; anion:anion antiporter activity; transcription cofactor activity; secondary active sulfate transmembrane transporter activity; transcription factor activity
Biological Process: intracellular pH elevation; regulation of transcription, DNA-dependent; membrane hyperpolarization; ion transport; excretion; transmembrane transport; anion transport; sperm capacitation
Reference #:  P40879 (UniProtKB)
Alt. Names/Synonyms: Chloride anion exchanger; CLD; Down-regulated in adenoma; down-regulated in adenoma protein; DRA; Protein DRA; S26A3; SLC26A3; Solute carrier family 26 member 3; solute carrier family 26, member 3
Gene Symbols: SLC26A3
Molecular weight: 84,505 Da
Basal Isoelectric point: 8.87  Predict pI for various phosphorylation states
Select Structure to View Below

SLC26A3

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T503-p LLTIVFRtQFPKCsT
0 1 S509-p RtQFPKCsTLANIGR
0 1 Y520-p NIGRTNIyKNKKDYY
0 41 Y756-p GGLRNRVyEVPVETK
  rat

 
T496 LLTIVFRTQFPKCST
S502 RTQFPKCSTLANVGR
Y513 NVGRSNIYKNKKNYA
C749 GGLRNRECQVPVETK
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