Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
SLC26A3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SLC26A3 Chloride/bicarbonate exchanger. Mediates the efficient absorbtion of chloride ions in the colon, participating in fluid homeostasis. Defects in SLC26A3 are the cause of diarrhea type 1 (DIAR1); also known as congenital chloride diarrhea (CLD). DIAR1 is a disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Cellular Component: membrane; brush border membrane; apical plasma membrane; integral to membrane; plasma membrane
Molecular Function: bicarbonate transmembrane transporter activity; protein binding; chloride transmembrane transporter activity; transporter activity; anion:anion antiporter activity; secondary active sulfate transmembrane transporter activity; transcription cofactor activity; transcription factor activity
Biological Process: intracellular pH elevation; regulation of transcription, DNA-dependent; bicarbonate transport; membrane hyperpolarization; ion transport; excretion; transmembrane transport; sperm capacitation; anion transport
Reference #:  P40879 (UniProtKB)
Alt. Names/Synonyms: Chloride anion exchanger; CLD; Down-regulated in adenoma; down-regulated in adenoma protein; DRA; Protein DRA; S26A3; SLC26A3; Solute carrier family 26 member 3; solute carrier family 26, member 3
Gene Symbols: SLC26A3
Molecular weight: 84,505 Da
Basal Isoelectric point: 8.87  Predict pI for various phosphorylation states
Select Structure to View Below

SLC26A3

Protein Structure Not Found.


STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K449-ub ALALGNLkGMLMQFA
0 1 T503-p LLTIVFRtQFPKCsT
0 1 S509-p RtQFPKCsTLANIGR
0 1 Y520-p NIGRTNIyKNKKDYY
0 1 Y526 IyKNKKDYYDMYEPE
0 41 Y756-p GGLRNRVyEVPVETK
  rat

 
K442 ALALGNLKGMLMQFA
T496 LLTIVFRTQFPKCST
S502 RTQFPKCSTLANVGR
Y513 NVGRSNIYKNKKNyA
Y519-p IYKNKKNyADVYEPE
C749 GGLRNRECQVPVETK
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.