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PLXNA4 (human)

Overview PLXNA4 Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Interacts with NRP1 and NRP2. Belongs to the plexin family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral Cellular Component: plasma membrane; integral to membrane; intracellular Molecular Function: semaphorin receptor activity Biological Process: axon guidance; sympathetic nervous system development; anterior commissure morphogenesis; glossopharyngeal nerve morphogenesis; facial nerve morphogenesis; regulation of axon extension involved in axon guidance; postganglionic parasympathetic nervous system development; regulation of negative chemotaxis; vagus nerve morphogenesis; trigeminal nerve morphogenesis; chemorepulsion of branchiomotor axon Reference #:  Q9HCM2 (UniProtKB) Alt. Names/Synonyms: DKFZp434G0625; DKFZp566O0546; FAYV2820; FLJ35026; FLJ38287; KIAA1550; PLEXA4; plexin A4; Plexin-A4; PLXA4; PLXNA4; PLXNA4A; PLXNA4B; PRO34003 Gene Symbols: PLXNA4 Molecular weight: 212,455 Da Basal Isoelectric point: 6.42  Predict pI for various phosphorylation states CST Pathways:  Regulation of Actin Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PLXNA4 4E74 - A=1488-1603 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		Y159-p	PYHKKEHyLSGVNEs
0	1		S166-p	yLSGVNEsGSVFGVI
0	1		K344-a	TVFSKGQkRKMKSLD
0	1		S946-p	PEFMARSsQLYYFMT
0	1		S1002-p	LFHRRSPsyIVCNTt
0	1		Y1003-p	FHRRSPsyIVCNTtS
0	1		T1009-p	syIVCNTtSSDEVLE
0	1		Y1138-p	LNKTNFTyyPNPVFE
0	1		Y1139-p	NKTNFTyyPNPVFEA
0	1		S1232-p	MVYIAPDsPLsLPAI
0	1		S1235-p	IAPDsPLsLPAIVSI
0	1		K1350-a	YRQERVEkGLKLFAQ
0	1		K1415	LLADLIDKNLESKNH
0	1		Y1483-p	AITGEARySLSEDKL
0	1		Y1497-p	LIRQQIDyKTLVLSC
0	1		S1506	TLVLSCVSPDNANSP
0	1		S1512	VSPDNANSPEVPVKI
0	4		S1630	NMIRYTGSPDsLRSR
0	4		S1633-p	RYTGSPDsLRSRTPM
0	1		T1642	RSRTPMITPDLESGV
0	1		-	gap
0	2		-	gap
0	2		-	gap

	PLXNA4 iso2
Y159	PYHKKEHYLSGVNES
S166	YLSGVNESGSVFGVI
K344	TVFSKGQKRKMKSLD
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	under review
-	gap
-	gap
-	gap
-	under review
-	gap
-	gap
-	under review
T461-p	KLKKMPGtsLCPtLE
S462-p	LKKMPGtsLCPtLEL
T466-p	PGtsLCPtLELQTGP

	mouse
Y158	PFHKKEHYLSGVNES
S165	YLSGVNESGSVFGVI
K343	TVFSKGQKRKMKSLD
S945	PEFMARSSQLYYFMT
S1001	LFHRRSPSYIICNTT
Y1002	FHRRSPSYIICNTTS
T1008	SYIICNTTSSEEVLD
Y1137	LNKTNFTYYPNPVFE
Y1138	NKTNFTYYPNPVFEA
S1231	MVYIAPDSPLSLPAI
S1234	IAPDSPLSLPAIVSI
K1349	YRQERVEKGLKLFAQ
K1414-u	LLADLIDkNLESKNH
Y1482	AITGEARYSLSEDKL
Y1496	LIRQQIEYKTLVLSC
S1505-p	TLVLSCVsPDNVNsP
S1511-p	VsPDNVNsPEVPVKI
S1629-p	NMIRYTGsPDsLRSR
S1632-p	RYTGsPDsLRSRTPM
T1641-p	RSRTPMItPDLESGV
-	gap
-	gap
-	gap

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