Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Interacts with NRP1 and NRP2. Belongs to the plexin family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q32.3
Cellular Component: plasma membrane; integral to membrane; intracellular
Molecular Function: semaphorin receptor activity
Biological Process: axon guidance; sympathetic nervous system development; anterior commissure morphogenesis; glossopharyngeal nerve morphogenesis; regulation of axon extension involved in axon guidance; facial nerve morphogenesis; postganglionic parasympathetic nervous system development; regulation of negative chemotaxis; vagus nerve morphogenesis; chemorepulsion of branchiomotor axon; trigeminal nerve morphogenesis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.