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Protein Page:
PLXNA4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PLXNA4 Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Interacts with NRP1 and NRP2. Belongs to the plexin family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Cellular Component: integral to membrane; plasma membrane; intracellular
Molecular Function: semaphorin receptor activity
Biological Process: axon guidance; sympathetic nervous system development; anterior commissure morphogenesis; glossopharyngeal nerve morphogenesis; facial nerve morphogenesis; regulation of axon extension involved in axon guidance; postganglionic parasympathetic nervous system development; regulation of negative chemotaxis; vagus nerve morphogenesis; trigeminal nerve morphogenesis; chemorepulsion of branchiomotor axon
Reference #:  Q9HCM2 (UniProtKB)
Alt. Names/Synonyms: DKFZp434G0625; DKFZp566O0546; FAYV2820; FLJ35026; FLJ38287; KIAA1550; PLEXA4; plexin A4; Plexin-A4; PLXA4; PLXNA4; PLXNA4A; PLXNA4B; PRO34003
Gene Symbols: PLXNA4
Molecular weight: 212,455 Da
Basal Isoelectric point: 6.42  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PLXNA4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 Y159-p PYHKKEHyLSGVNEs
0 1 S166-p yLSGVNEsGSVFGVI
0 1 K344-ac TVFSKGQkRKMKSLD
0 1 - gap
0 2 - gap
0 2 - gap
0 1 S488-p VLRDMAFsKDHEQLY
0 1 S946-p PEFMARSsQLYYFMT
0 1 S1002-p LFHRRSPsyIVCNTt
0 1 Y1003-p FHRRSPsyIVCNTtS
0 1 T1009-p syIVCNTtSSDEVLE
0 1 Y1138-p LNKTNFTyyPNPVFE
0 1 Y1139-p NKTNFTyyPNPVFEA
0 1 S1232-p MVYIAPDsPLsLPAI
0 1 S1235-p IAPDsPLsLPAIVSI
0 1 K1350-ac YRQERVEkGLKLFAQ
0 1 K1415 LLADLIDKNLESKNH
0 1 Y1483-p AITGEARySLSEDKL
0 1 Y1497-p LIRQQIDyKTLVLSC
0 1 S1506 TLVLSCVSPDNANSP
0 1 S1512 VSPDNANSPEVPVKI
0 6 S1630-p NMIRYTGsPDsLRSR
0 5 S1633-p RYTGsPDsLRSRTPM
0 1 T1642 RSRTPMITPDLESGV
  PLXNA4 iso2  
Y159 PYHKKEHYLSGVNES
S166 YLSGVNESGSVFGVI
K344 TVFSKGQKRKMKSLD
T461-p KLKKMPGtsLCPtLE
S462-p LKKMPGtsLCPtLEL
T466-p PGtsLCPtLELQTGP
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  mouse

 
Y158 PFHKKEHYLSGVNES
S165 YLSGVNESGSVFGVI
K343 TVFSKGQKRKMKSLD
- gap
- gap
- gap
S487 VLRDMAFSKDHEQLY
S945 PEFMARSSQLYYFMT
S1001 LFHRRSPSYIICNTT
Y1002 FHRRSPSYIICNTTS
T1008 SYIICNTTSSEEVLD
Y1137 LNKTNFTYYPNPVFE
Y1138 NKTNFTYYPNPVFEA
S1231 MVYIAPDSPLSLPAI
S1234 IAPDSPLSLPAIVSI
K1349 YRQERVEKGLKLFAQ
K1414-ub LLADLIDkNLESKNH
Y1482 AITGEARYSLSEDKL
Y1496 LIRQQIEYKTLVLSC
S1505-p TLVLSCVsPDNVNsP
S1511-p VsPDNVNsPEVPVKI
S1629-p NMIRYTGsPDsLRSR
S1632-p RYTGsPDsLRSRTPM
T1641-p RSRTPMItPDLESGV
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