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PCK2 (human)

Overview PCK2 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Monomer. Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Kinase, other; Mitochondrial; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - citrate (TCA) cycle; EC 4.1.1.32; Lyase; Carbohydrate Metabolism - pyruvate Cellular Component: mitochondrion; mitochondrial matrix Molecular Function: protein binding; GTP binding; phosphoenolpyruvate carboxykinase (GTP) activity; metal ion binding; phosphoenolpyruvate carboxykinase activity Biological Process: oxaloacetate metabolic process; carbohydrate metabolic process; response to glucocorticoid stimulus; glucose metabolic process; gluconeogenesis Reference #:  Q16822 (UniProtKB) Alt. Names/Synonyms: PCK2; PCKGM; PEP carboxykinase; PEPCK; PEPCK-M; PEPCK2; phosphoenolpyruvate carboxykinase 2 (mitochondrial); Phosphoenolpyruvate carboxykinase [GTP], mitochondrial; Phosphoenolpyruvate carboxylase; phosphopyruvate carboxylase Gene Symbols: PCK2 Molecular weight: 70,730 Da Basal Isoelectric point: 7.57  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PCK2

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T97-p	NNCWLARtDPKDVAR
0	1		K108-u	DVARVESkTVIVTPS
0	1		T113	ESkTVIVTPSQRDTV
0	1		S115	kTVIVTPSQRDTVQL
0	1		S270-p	CFALRIAsRLARDEG
0	9		S304-p	YVAAAFPsACGKTNL
0	1		S422-p	EPCAHPNsRFCAPAR
0	1		T593-p	GLRAIDTtQLFSLPK
0	1		K624-a	QVNQDLPkEVLAELE

	mouse
T97	KNCWLARTDPKDVAR
K108	DVARVESKTVIVtPs
T113-p	ESKTVIVtPsQRDTV
S115-p	KTVIVtPsQRDTVPL
S270	CFALRIASRLARDEG
S304-p	YVAAAFPsACGKTNL
S422	EPCAHPNSRFCVPAR
S593	GLSAVDTSQLFSIPK
K624	QVNQDLPKEVLAELE

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