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Protein Page:
PCK2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PCK2 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Monomer. Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 4.1.1.32; Kinase, other; Lyase; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Mitochondrial
Cellular Component: mitochondrion; mitochondrial matrix
Molecular Function: protein binding; GTP binding; metal ion binding; phosphoenolpyruvate carboxykinase (GTP) activity; phosphoenolpyruvate carboxykinase activity
Biological Process: NADH oxidation; oxaloacetate metabolic process; response to glucocorticoid stimulus; carbohydrate metabolic process; glucose metabolic process; positive regulation of insulin secretion; pyruvate metabolic process; gluconeogenesis
Reference #:  Q16822 (UniProtKB)
Alt. Names/Synonyms: PCK2; PCKGM; PEP carboxykinase; PEPCK; PEPCK-M; PEPCK2; phosphoenolpyruvate carboxykinase 2 (mitochondrial); Phosphoenolpyruvate carboxykinase [GTP], mitochondrial; Phosphoenolpyruvate carboxylase; phosphopyruvate carboxylase
Gene Symbols: PCK2
Molecular weight: 70,730 Da
Basal Isoelectric point: 7.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PCK2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S34-p IQTLRVLsGDLGQLP
0 1 T42-p GDLGQLPtGIRDFVE
0 1 T97-p NNCWLARtDPkDVAR
0 1 K100-sc WLARtDPkDVARVES
0 1 K108-ub DVARVESkTVIVTPs
0 1 T113 ESkTVIVTPsQRDTV
0 2 S115-p kTVIVTPsQRDTVQL
0 1 T196-p RIMTRLGtPVLQALG
0 1 S270-p CFALRIAsRLARDEG
0 10 S304-p YVAAAFPsACGKTNL
0 1 S422-p EPCAHPNsRFCAPAR
0 1 T593-p GLRAIDTtQLFSLPK
0 1 K624-ac QVNQDLPkEVLAELE
  mouse

 
S34 IQTLHVLSGDMSQLP
A42 GDMSQLPAGVRDFVA
T97 KNCWLARTDPKDVAR
K100 WLARTDPKDVARVES
K108 DVARVESKTVIVtPs
T113-p ESKTVIVtPsQRDTV
S115-p KTVIVtPsQRDTVPL
T196 RIMTRLGTPVLQALG
S270 CFALRIASRLARDEG
S304-p YVAAAFPsACGKTNL
S422 EPCAHPNSRFCVPAR
S593 GLSAVDTSQLFSIPK
K624 QVNQDLPKEVLAELE
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