Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
EVI1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
EVI1 a zinc finger transcriptional regulator that binds to DNA sequences in the promoter region of target genes and positively or negatively regulates their expression. An oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. Originally identified as a common site of viral integration in murine myeloid leukemia. Involved in human myeloid disorders through chromosome translocation and inversion and is also implicated in solid tumor formation. At least six isoforms of the human protein are formed due to alternative usage of 5'-ends, alternative splicing, and intergenic splicing which results in the formation of a fusion protein with MDS1, which can be expressed in normal tissues. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor; Methyltransferase, protein lysine, predicted; C2H2-type zinc finger protein; Transcription regulation; Oncoprotein
Cellular Component: histone deacetylase complex; nuclear speck; nucleus
Molecular Function: protein binding; protein homodimerization activity; DNA binding; metal ion binding; transcription factor activity
Biological Process: embryonic forelimb morphogenesis; negative regulation of JNK cascade; pericardium development; transcription, DNA-dependent; apoptosis; in utero embryonic development; regulation of cell cycle; positive regulation of transcription, DNA-dependent; neutrophil homeostasis; embryonic hindlimb morphogenesis; regulation of cell proliferation; post-embryonic development; regulation of transcription, DNA-dependent; response to bacterium; forebrain development; negative regulation of programmed cell death; positive regulation of transcription from RNA polymerase II promoter; cell differentiation; inflammatory response; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta receptor signaling pathway
Reference #:  Q03112 (UniProtKB)
Alt. Names/Synonyms: AML1-EVI-1 fusion partner; ecotropic viral integration site 1; Ecotropic virus integration site 1 protein homolog; EVI-1; EVI1; MDS1; MDS1 and EVI1 complex locus; MDS1 and EVI1 complex locus protein EVI1; MDS1 and EVI1 complex locus protein MDS1; MDS1-EVI1; MECOM; MGC163392; MGC97004; myelodysplasia syndrome 1 protein; myelodysplasia syndrome-associated protein 1; oncogene EVI1; PRDM3; zinc finger protein Evi1
Gene Symbols: MECOM
Molecular weight: 118,276 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

EVI1

Protein Structure Not Found.


STRING  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S64-p DFQQKLEsENDLQEI
0 1 S173-p GKTFATSsGLKQHKH
1 0 S196-p ICEVCHKsYTQFSNL
0 1 T215-p RMHADCRtQIKCKDC
0 4 S338-p EQTNKSQsPLMtHPQ
0 1 T342-p KSQsPLMtHPQILPA
0 5 S436-p KMFKDKVsPLQNLAS
0 1 K497-ub LVGLQDKkVGALPYP
0 1 S529-p FPDRDLRsLPLKMEP
1 4 S538-p PLKMEPQsPGEVKKL
0 1 G540 KMEPQsPGEVKKLQK
0 5 S552-p LQKGSSEsPFDLTTK
1 0 K564-ac TTKRKDEkPLtPVPS
0 1 T567-p RKDEkPLtPVPSKPP
0 1 K599 RSRASGTKLTEPRKN
0 1 S818-p KHENGNMsGTATSSP
0 1 S827-p TATSSPHsELEsTGA
0 1 S831-p SPHsELEsTGAILDD
0 6 S854-p IRNFIGNsNHGsQsP
1 3 S858-p IGNsNHGsQsPRNVE
1 15 S860-p NsNHGsQsPRNVEER
1 1 S885-p ALVTSQNsDLLDDEE
0 1 S986-p YSEAELSsFstSHVP
0 1 S988-p EAELSsFstSHVPEE
0 1 T989-p AELSsFstSHVPEEL
0 1 K1005-ac QPLHRKSkSQAyAMM
0 1 Y1009-p RKSkSQAyAMMLSLS
  EVI1 iso3  
S252 DFQQKLESENDLQEI
S361 GKTFATSSGLKQHKH
S384 ICEVCHKSYTQFSNL
T403 RMHADCRTQIKCKDC
S526 EQTNKSQSPLMTHPQ
T530 KSQSPLMTHPQILPA
S624 KMFKDKVSPLQNLAS
K685 LVGLQDKKVGALPYP
S717 FPDRDLRSLPLKMEP
S726 PLKMEPQSPGEVKKL
G728 KMEPQSPGEVKKLQK
S740 LQKGSSESPFDLTTK
K752 TTKRKDEKPLTPVPS
T755 RKDEKPLTPVPSKPP
K787 RSRASGTKLTEPRKN
S1006 KHENGNMSGTATSSP
S1015 TATSSPHSELESTGA
S1019 SPHSELESTGAILDD
S1042 IRNFIGNSNHGSQSP
S1046 IGNSNHGSQSPRNVE
S1048 NSNHGSQSPRNVEER
S1073 ALVTSQNSDLLDDEE
S1174 YSEAELSSFSTSHVP
S1176 EAELSSFSTSHVPEE
T1177 AELSSFSTSHVPEEL
K1193 QPLHRKSKSQAYAMM
Y1197 RKSKSQAYAMMLSLS
  mouse

 
S64 DLQQNLESESDLREI
S173 GKTFATSSGLKQHKH
S196 ICEVCHKSYTQFSNL
T215 RMHADCRTQIKCKDC
S338-p EQSNKCQsPLLTHPQ
T342 KCQsPLLTHPQILPA
S436-p KMFKDKVsPLQNLAS
K497 LVGLQDKKVGALPYP
S529 FPDRDLRSLPLKMEP
S538-p PLKMEPQsPsEVKKL
S540-p KMEPQsPsEVKKLQK
S552-p LQKGSSEsPFDLTTK
K564 TTKRKDEKPLTSGPS
T567 RKDEKPLTSGPSKPS
K599-ac RGRASGTkLTEPRKN
S809 KHENGNMSGTATSSP
S818 TATSSPHSELESAGA
S822 SPHSELESAGAILDD
S845-p IRNFIGNsNHGsQsP
S849-p IGNsNHGsQsPRNME
S851-p NsNHGsQsPRNMEER
S876 ALATSQNSDLLDDEE
S977 YTDAELSSISSSHVP
S979 DAELSSISSSHVPEE
S980 AELSSISSSHVPEEL
K996 QTLHRKSKSQAYAMM
Y1000 RKSKSQAYAMMLSLS
  rat

 
- under review  
- under review  
S63 SSEVCHKSYTQFSNL
T82 RMHADCRTQIKCKDC
S205 EQSNKCQSPLLTHPQ
T209 KCQSPLLTHPQILPA
S303 KMFKDKVSPLQNLAS
K364 LVGLQDKKVGALPYP
S396 FPDRDLRSLPLKMEP
S405 PLKMEPQSPSEVKKL
S407 KMEPQSPSEVKKLQK
S419 LQKGSSESPFDLTTK
K431 TTKRKDEKPLTSGSS
T434 RKDEKPLTSGSSKLP
K466 RSRASGTKLTEPRKN
S685 KHENGNMSGTATSSP
S694 TATSSPHSELESAGA
S698 SPHSELESAGAILDD
S721 IRNFIGNSNHGSQsP
S725 IGNSNHGSQsPRNME
S727-p NSNHGSQsPRNMEER
S752-p ALATSQNsDLLDDEE
- gap
- gap
S855 DAELSFGSSHVPEEL
K871 QPLHRKSKSQAYAMM
Y875 RKSKSQAYAMMLSLS
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.