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PRDM3 (human)

Overview PRDM3 a zinc finger transcriptional regulator that binds to DNA sequences in the promoter region of target genes and positively or negatively regulates their expression. An oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. Originally identified as a common site of viral integration in murine myeloid leukemia. Involved in human myeloid disorders through chromosome translocation and inversion and is also implicated in solid tumor formation. At least six isoforms of the human protein are formed due to alternative usage of 5'-ends, alternative splicing, and intergenic splicing which results in the formation of a fusion protein with MDS1, which can be expressed in normal tissues. Note: This description may include information from UniProtKB. Protein type: Oncoprotein; Methyltransferase, protein lysine, predicted; C2H2-type zinc finger protein; Transcription, coactivator/corepressor; Transcription regulation Cellular Component: histone deacetylase complex; nuclear speck; nucleus Molecular Function: protein binding; protein homodimerization activity; DNA binding; zinc ion binding; transcription factor activity Biological Process: embryonic forelimb morphogenesis; pericardium development; negative regulation of JNK cascade; transcription, DNA-dependent; in utero embryonic development; regulation of cell cycle; apoptosis; positive regulation of transcription, DNA-dependent; neutrophil homeostasis; embryonic hindlimb morphogenesis; post-embryonic development; regulation of cell proliferation; response to external stimulus; regulation of transcription, DNA-dependent; response to bacterium; forebrain development; negative regulation of programmed cell death; positive regulation of transcription from RNA polymerase II promoter; cell differentiation; negative regulation of transforming growth factor beta receptor signaling pathway; inflammatory response; negative regulation of transcription, DNA-dependent Reference #:  Q03112 (UniProtKB) Alt. Names/Synonyms: AML1-EVI-1 fusion partner; ecotropic viral integration site 1; Ecotropic virus integration site 1 protein homolog; EVI-1; EVI1; MDS1; MDS1 and EVI1 complex locus; MDS1 and EVI1 complex locus protein EVI1; MDS1 and EVI1 complex locus protein MDS1; MDS1-EVI1; MECOM; MGC163392; MGC97004; myelodysplasia syndrome 1 protein; myelodysplasia syndrome-associated protein 1; oncogene EVI1; PRDM3; zinc finger protein Evi1 Gene Symbols: MECOM Molecular weight: 118,276 Da Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PRDM3

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 165215 600049  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		T215-p	RMHADCRtQIKCKDC
0	1		S338	EQTNKSQSPLMtHPQ
0	1		T342-p	KSQSPLMtHPQILPA
0	2		S436-p	KMFKDKVsPLQNLAS
0	1		K497-u	LVGLQDKkVGALPYP
0	1		S529-p	FPDRDLRsLPLKMEP
0	2		S538-p	PLKMEPQsPGEVKKL
0	1		G540	KMEPQsPGEVKKLQK
0	2		S552-p	LQKGSSEsPFDLTTK
1	0		K564-a	TTKRKDEkPLTPVPS
0	1		K599	RSRASGTKLTEPRKN
0	2		S854	IRNFIGNSNHGsQsP
0	2		S858-p	IGNSNHGsQsPRNVE
0	9		S860-p	NSNHGsQsPRNVEER
0	1		S986-p	YSEAELSsFstSHVP
0	1		S988-p	EAELSsFstSHVPEE
0	1		T989-p	AELSsFstSHVPEEL
0	1		K1005-a	QPLHRKSkSQAyAMM
0	1		Y1009-p	RKSkSQAyAMMLSLS

	PRDM3 iso3
T403	RMHADCRTQIKCKDC
S526	EQTNKSQSPLMTHPQ
T530	KSQSPLMTHPQILPA
S624	KMFKDKVSPLQNLAS
K685	LVGLQDKKVGALPYP
S717	FPDRDLRSLPLKMEP
S726	PLKMEPQSPGEVKKL
G728	KMEPQSPGEVKKLQK
S740	LQKGSSESPFDLTTK
K752	TTKRKDEKPLTPVPS
K787	RSRASGTKLTEPRKN
S1042	IRNFIGNSNHGSQSP
S1046	IGNSNHGSQSPRNVE
S1048	NSNHGSQSPRNVEER
S1174	YSEAELSSFSTSHVP
S1176	EAELSSFSTSHVPEE
T1177	AELSSFSTSHVPEEL
K1193	QPLHRKSKSQAYAMM
Y1197	RKSKSQAYAMMLSLS

	mouse
T215	RMHADCRTQIKCKDC
S338-p	EQSNKCQsPLLTHPQ
T342	KCQsPLLTHPQILPA
S436-p	KMFKDKVsPLQNLAS
K497	LVGLQDKKVGALPYP
S529	FPDRDLRSLPLKMEP
S538-p	PLKMEPQsPsEVKKL
S540-p	KMEPQsPsEVKKLQK
S552-p	LQKGSSEsPFDLTTK
K564	TTKRKDEKPLTSGPS
K599-a	RGRASGTkLTEPRKN
S845-p	IRNFIGNsNHGsQsP
S849-p	IGNsNHGsQsPRNME
S851-p	NsNHGsQsPRNMEER
S977	YTDAELSSISSSHVP
S979	DAELSSISSSHVPEE
S980	AELSSISSSHVPEEL
K996	QTLHRKSKSQAYAMM
Y1000	RKSKSQAYAMMLSLS

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