Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
PANK2 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PANK2 a pantothenate kinase that catalyzes the first committed step in the biosynthesis of coenzyme A, an essential cofactor in cellular metabolism. PANK2 is predominantly localized in mitochondria in primates. Defects in PANK2 are the cause of pantothenate kinase-associated neurodegeneration (PKAN), an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain. Three isoforms of the human PANK2, produced by alternative splicing, have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.1.33; Kinase, other; Mitochondrial; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis
Cellular Component: mitochondrion; cytosol
Molecular Function: pantothenate kinase activity
Biological Process: coenzyme A biosynthetic process; regulation of mitochondrial membrane potential; aerobic respiration; phosphorylation; spermatid development
Reference #:  Q7M753 (UniProtKB)
Alt. Names/Synonyms: 4933409I19Rik; AI642621; MGC118448; OTTMUSP00000017161; Pank2; Pantothenate kinase 2; pantothenate kinase 2 (Hallervorden-Spatz syndrome)
Gene Symbols: Pank2
Molecular weight: 50,212 Da
Basal Isoelectric point: 9.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PANK2

Protein Structure Not Found.


STRING  |  Reactome  |  BioGPS  |  Scansite  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 2 S33-p QGRAAATsAAVGESA
0 198 S55-p DPLRRRAssAAPsGS
0 118 S56-p PLRRRAssAAPsGSG
0 11 A58 RRRAssAAPsGSGEA
0 2 S60-p RAssAAPsGSGEAES
0 701 S75-p VRRERPGsLGGSTSA
0 49 L76 RRERPGsLGGSTSAG
0 34 G77 RERPGsLGGSTSAGR
0 2 T80 PGsLGGSTSAGRPRA
0 2 S81 GsLGGSTSAGRPRAE
0 1 G89 AGRPRAEGLRKRRPL
0 1 K132 KEEVESLKSIRkYLT
0 2 K136-ub ESLKSIRkYLTSNVA
0 1 S281 VNIGSGVSILAVYSK
0 1 Y286 GVSILAVYSKDNYKR
0 1 Y291 AVYSKDNYKRVTGTS
0 1 S356 LPGWAVASSFGNMMS
0 1 S357 PGWAVASSFGNMMSK
0 1 S363 SSFGNMMSKEKREAA
0 2 K429-ub YALDYWSkGQLKALF
  human

► Hide Isoforms
 
S143-p HGRASATsVSSAGEQ
S168-p EPLRRRAssAsVPAV
S169-p PLRRRAssAsVPAVG
S171-p RRRAssAsVPAVGAS
P173 RAssAsVPAVGASAE
S189-p TRRDRLGsysGPtsV
Y190-p RRDRLGsysGPtsVS
S191-p RDRLGsysGPtsVSR
T194-p LGsysGPtsVSRQRV
S195-p GsysGPtsVSRQRVE
S203-p VSRQRVEsLRKKRPL
K246-ub EEEVESLkSIRkYLT
K250-ub ESLkSIRkYLTSNVA
S395-p VNIGSGVsILAVySK
Y400-p GVsILAVySKDNyKR
Y405-p AVySKDNyKRVTGTS
S470-p LPGWAVAssFGNMMs
S471-p PGWAVAssFGNMMsK
S477-p ssFGNMMsKEKREAV
K543-ub YALDYWSkGQLKALF
  PANK2 iso2  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S104 VNIGSGVSILAVYSK
Y109 GVSILAVYSKDNYKR
Y114 AVYSKDNYKRVTGTS
S179 LPGWAVASSFGNMMS
S180 PGWAVASSFGNMMSK
S186 SSFGNMMSKEKREAV
K252 YALDYWSKGQLKALF
  PANK2 iso3  
S20 HGRASATSVSSAGEQ
S45 EPLRRRASSASVPAV
S46 PLRRRASSASVPAVG
S48 RRRASSASVPAVGAS
P50 RASSASVPAVGASAE
S66 TRRDRLGSYSGPTSV
Y67 RRDRLGSYSGPTSVS
S68 RDRLGSYSGPTSVSR
T71 LGSYSGPTSVSRQRV
S72 GSYSGPTSVSRQRVE
S80 VSRQRVESLRKKRPL
K123 EEEVESLKSIRKYLT
K127 ESLKSIRKYLTSNVA
S272 VNIGSGVSILAVYSK
Y277 GVSILAVYSKDNYKR
Y282 AVYSKDNYKRVTGTS
S347 LPGWAVASSFGNMMS
S348 PGWAVASSFGNMMSK
S354 SSFGNMMSKEKREAV
K420 YALDYWSKGQLKALF
  PANK2 iso4  
S33 HGRASATSVSSAGEQ
S58 EPLRRRASSASVPAV
S59 PLRRRASSASVPAVG
S61 RRRASSASVPAVGAS
P63 RASSASVPAVGASAE
S79 TRRDRLGSYSGPTSV
Y80 RRDRLGSYSGPTSVS
S81 RDRLGSYSGPTSVSR
T84 LGSYSGPTSVSRQRV
S85 GSYSGPTSVSRQRVE
S93 VSRQRVESLRKKRPL
K136 EEEVESLKSIRKYLT
K140 ESLKSIRKYLTSNVA
S285 VNIGSGVSILAVYSK
Y290 GVSILAVYSKDNYKR
Y295 AVYSKDNYKRVTGTS
S360 LPGWAVASSFGNMMS
S361 PGWAVASSFGNMMSK
S367 SSFGNMMSKEKREAV
K433 YALDYWSKGQLKALF
  rat

 
S20 QGRAAATSAAAGESA
S42-p EPLRRRAssAAPSES
S43-p PLRRRAssAAPSESG
A45 RRRAssAAPSESGPA
S47 RAssAAPSESGPAES
S62 LRRERPGSLGGSVSA
L63 RRERPGSLGGSVSAA
G64 RERPGSLGGSVSAAR
V67 PGSLGGSVSAARPRG
S68 GSLGGSVSAARPRGE
G76 AARPRGEGLRKRRPL
K119 KEEVESLKSIRKYLT
K123 ESLKSIRKYLTSNVA
S268 VNIGSGVSILAVYSK
Y273 GVSILAVYSKDNYKR
Y278 AVYSKDNYKRVTGTS
S343 LPGWAVASSFGNMMS
S344 PGWAVASSFGNMMSK
S350 SSFGNMMSKEKREAA
K416 YALDYWSKGQLKALF
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.