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Protein Page:
PANK2 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PANK2 a pantothenate kinase that catalyzes the first committed step in the biosynthesis of coenzyme A, an essential cofactor in cellular metabolism. PANK2 is predominantly localized in mitochondria in primates. Defects in PANK2 are the cause of pantothenate kinase-associated neurodegeneration (PKAN), an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain. Three isoforms of the human PANK2, produced by alternative splicing, have been reported. Note: This description may include information from UniProtKB.
Protein type: Kinase, other; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; Mitochondrial; EC 2.7.1.33
Cellular Component: mitochondrion; cytosol
Molecular Function: transferase activity; kinase activity; pantothenate kinase activity
Biological Process: coenzyme A biosynthetic process; regulation of mitochondrial membrane potential; aerobic respiration; phosphorylation; spermatid development
Reference #:  Q7M753 (UniProtKB)
Alt. Names/Synonyms: 4933409I19Rik; AI642621; MGC118448; OTTMUSP00000017161; Pank2; Pantothenate kinase 2; pantothenate kinase 2 (Hallervorden-Spatz syndrome)
Gene Symbols: Pank2
Molecular weight: 50,212 Da
Basal Isoelectric point: 9.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PANK2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 2 S33-p QGRAAATsAAVGESA
0 197 S55-p DPLRRRAssAAPsGS
0 118 S56-p PLRRRAssAAPsGSG
0 11 A58 RRRAssAAPsGSGEA
0 2 S60-p RAssAAPsGSGEAES
0 698 S75-p VRRERPGsLGGSTSA
0 48 L76 RRERPGsLGGSTSAG
0 34 G77 RERPGsLGGSTSAGR
0 2 T80 PGsLGGSTSAGRPRA
0 2 S81 GsLGGSTSAGRPRAE
0 1 G89 AGRPRAEGLRKRRPL
0 1 K132 KEEVESLKSIRkYLT
0 2 K136-ub ESLKSIRkYLTSNVA
0 1 S281 VNIGSGVSILAVYSK
0 1 Y286 GVSILAVYSKDNYKR
0 1 Y291 AVYSKDNYKRVTGTS
0 1 S356 LPGWAVASSFGNMMS
0 1 S357 PGWAVASSFGNMMSK
0 1 S363 SSFGNMMSKEKREAA
0 2 K429-ub YALDYWSkGQLKALF
  human

 
S143-p HGRASATsVSSAGEQ
S168-p EPLRRRAssAsVPAV
S169-p PLRRRAssAsVPAVG
S171-p RRRAssAsVPAVGAS
P173 RAssAsVPAVGASAE
S189-p TRRDRLGsysGPtsV
Y190-p RRDRLGsysGPtsVS
S191-p RDRLGsysGPtsVSR
T194-p LGsysGPtsVSRQRV
S195-p GsysGPtsVSRQRVE
S203-p VSRQRVEsLRKKRPL
K246-ub EEEVESLkSIRkYLT
K250-ub ESLkSIRkYLTSNVA
S395-p VNIGSGVsILAVySK
Y400-p GVsILAVySKDNyKR
Y405-p AVySKDNyKRVTGTS
S470-p LPGWAVAssFGNMMs
S471-p PGWAVAssFGNMMsK
S477-p ssFGNMMsKEKREAV
K543-ub YALDYWSkGQLKALF
  rat

 
S20 QGRAAATSAAAGESA
S42-p EPLRRRAssAAPSES
S43-p PLRRRAssAAPSESG
A45 RRRAssAAPSESGPA
S47 RAssAAPSESGPAES
S62 LRRERPGSLGGSVSA
L63 RRERPGSLGGSVSAA
G64 RERPGSLGGSVSAAR
V67 PGSLGGSVSAARPRG
S68 GSLGGSVSAARPRGE
G76 AARPRGEGLRKRRPL
K119 KEEVESLKSIRKYLT
K123 ESLKSIRKYLTSNVA
S268 VNIGSGVSILAVYSK
Y273 GVSILAVYSKDNYKR
Y278 AVYSKDNYKRVTGTS
S343 LPGWAVASSFGNMMS
S344 PGWAVASSFGNMMSK
S350 SSFGNMMSKEKREAA
K416 YALDYWSKGQLKALF
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