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Protein Page:
PANK2 (mouse)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PANK2 a pantothenate kinase that catalyzes the first committed step in the biosynthesis of coenzyme A, an essential cofactor in cellular metabolism. PANK2 is predominantly localized in mitochondria in primates. Defects in PANK2 are the cause of pantothenate kinase-associated neurodegeneration (PKAN), an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain. Three isoforms of the human PANK2, produced by alternative splicing, have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.1.33; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; Kinase, other; Mitochondrial
Cellular Component: mitochondrion; cytosol
Molecular Function: transferase activity; kinase activity; pantothenate kinase activity
Biological Process: coenzyme A biosynthetic process; regulation of mitochondrial membrane potential; aerobic respiration; phosphorylation; spermatid development
Reference #:  Q7M753 (UniProtKB)
Alt. Names/Synonyms: 4933409I19Rik; AI642621; MGC118448; OTTMUSP00000017161; Pank2; Pantothenate kinase 2; pantothenate kinase 2 (Hallervorden-Spatz syndrome)
Gene Symbols: Pank2
Molecular weight: 50,212 Da
Basal Isoelectric point: 9.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PANK2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 2 S33-p QGRAAATsAAVGESA
0 190 S55-p DPLRRRAssAAPsGS
0 111 S56-p PLRRRAssAAPsGSG
0 11 A58 RRRAssAAPsGSGEA
0 2 S60-p RAssAAPsGSGEAES
0 648 S75-p VRRERPGsLGGSTSA
0 49 L76 RRERPGsLGGSTSAG
0 33 G77 RERPGsLGGSTSAGR
0 2 S81 GsLGGSTSAGRPRAE
0 1 K132 KEEVESLKSIRkYLT
0 2 K136-u ESLKSIRkYLTSNVA
0 2 K429-u YALDYWSkGQLKALF
  human

 
S143-p HGRASATsVSSAGEQ
S168-p EPLRRRAssAsVPAV
S169-p PLRRRAssAsVPAVG
S171-p RRRAssAsVPAVGAS
P173 RAssAsVPAVGASAE
S189-p TRRDRLGsysGPTsV
Y190-p RRDRLGsysGPTsVS
S191-p RDRLGsysGPTsVSR
S195-p GsysGPTsVSRQRVE
K246-u EEEVESLkSIRkYLT
K250-u ESLkSIRkYLTSNVA
K543-u YALDYWSkGQLKALF
  rat

 
S20 QGRAAATSAAAGESA
S42-p EPLRRRAssAAPSES
S43-p PLRRRAssAAPSESG
A45 RRRAssAAPSESGPA
S47 RAssAAPSESGPAES
S62 LRRERPGSLGGSVSA
L63 RRERPGSLGGSVSAA
G64 RERPGSLGGSVSAAR
S68 GSLGGSVSAARPRGE
K119 KEEVESLKSIRKYLT
K123 ESLKSIRKYLTSNVA
K416 YALDYWSKGQLKALF
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