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PANK2 (mouse)

Overview PANK2 a pantothenate kinase that catalyzes the first committed step in the biosynthesis of coenzyme A, an essential cofactor in cellular metabolism. PANK2 is predominantly localized in mitochondria in primates. Defects in PANK2 are the cause of pantothenate kinase-associated neurodegeneration (PKAN), an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain. Three isoforms of the human PANK2, produced by alternative splicing, have been reported. Note: This description may include information from UniProtKB. Protein type: Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; EC 2.7.1.33; Mitochondrial; Kinase, other Cellular Component: mitochondrion Molecular Function: kinase activity; pantothenate kinase activity Biological Process: phosphorylation Reference #:  Q7M753 (UniProtKB) Alt. Names/Synonyms: 4933409I19Rik; AI642621; MGC118448; OTTMUSP00000017161; Pank2; Pantothenate kinase 2; pantothenate kinase 2 (Hallervorden-Spatz syndrome) Gene Symbols: Pank2 Molecular weight: 50,212 Da Basal Isoelectric point: 9.06  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PANK2

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
0	2		S33-p	QGRAAATsAAVGESA
0	189		S55-p	DPLRRRAssAAPsGS
0	110		S56-p	PLRRRAssAAPsGSG
0	10		A58	RRRAssAAPsGSGEA
0	2		S60-p	RAssAAPsGSGEAES
0	646		S75-p	VRRERPGsLGGSTSA
0	49		L76	RRERPGsLGGSTSAG
0	33		G77	RERPGsLGGSTSAGR
0	1		T80	PGsLGGSTSAGRPRA
0	2		S81	GsLGGSTSAGRPRAE
0	1		K132	KEEVESLKSIRkYLT
0	2		K136-u	ESLKSIRkYLTSNVA
0	1		S281	VNIGSGVSILAVYSK
0	1		Y286	GVSILAVYSKDNYKR
0	1		Y291	AVYSKDNYKRVTGTS
0	2		K429-u	YALDYWSkGQLKALF

	human
S143-p	HGRASATsVSSAGEQ
S168-p	EPLRRRAssAsVPAV
S169-p	PLRRRAssAsVPAVG
S171-p	RRRAssAsVPAVGAS
P173	RAssAsVPAVGASAE
S189-p	TRRDRLGsysGPtsV
Y190-p	RRDRLGsysGPtsVS
S191-p	RDRLGsysGPtsVSR
T194-p	LGsysGPtsVSRQRV
S195-p	GsysGPtsVSRQRVE
K246-u	EEEVESLkSIRkYLT
K250-u	ESLkSIRkYLTSNVA
S395-p	VNIGSGVsILAVySK
Y400-p	GVsILAVySKDNyKR
Y405-p	AVySKDNyKRVTGTS
K543-u	YALDYWSkGQLKALF

	rat
S20	QGRAAATSAAAGESA
S42-p	EPLRRRAssAAPSES
S43-p	PLRRRAssAAPSESG
A45	RRRAssAAPSESGPA
S47	RAssAAPSESGPAES
S62	LRRERPGSLGGSVSA
L63	RRERPGSLGGSVSAA
G64	RERPGSLGGSVSAAR
V67	PGSLGGSVSAARPRG
S68	GSLGGSVSAARPRGE
K119	KEEVESLKSIRKYLT
K123	ESLKSIRKYLTSNVA
S268	VNIGSGVSILAVYSK
Y273	GVSILAVYSKDNYKR
Y278	AVYSKDNYKRVTGTS
K416	YALDYWSKGQLKALF

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