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Protein Page:
GDF15 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GDF15 disulfide-linked. Belongs to the TGF-beta family. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Cytokine; Secreted
Cellular Component: extracellular space; extracellular region
Molecular Function: growth factor activity; cytokine activity
Biological Process: cell-cell signaling; transforming growth factor beta receptor signaling pathway; signal transduction
Reference #:  Q99988 (UniProtKB)
Alt. Names/Synonyms: GDF-15; GDF15; growth differentiation factor 15; Growth/differentiation factor 15; Macrophage inhibitory cytokine 1; MIC-1; MIC1; NAG-1; NRG-1; NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; PDF; PLAB; Placental bone morphogenetic protein; Placental TGF-beta; Prostate differentiation factor; PTGF-beta; PTGFB
Gene Symbols: GDF15
Molecular weight: 34,140 Da
Basal Isoelectric point: 9.79  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GDF15

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S44-ga RASFPGPsELHSEDS
0 1 S146-p RPLRRQLsLARPQAP
0 1 K265-ub KTSLHRLkPDTVPAP
0 1 K303-ub TYDDLLAkDCHCI__
  mouse

 
S46 AMPEQRPSGPESQLN
S146 RPLKRALSLRGPRAP
Q260 KARLHGLQPDKVPAP
R298 TYDDLVARGCHCA__
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