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nestin (rat)

Overview nestin an intermediate filament protein. It is expressed predominantly in stem cells of the central nervous system in the neural tube. Upon terminal neural differentiation, nestin is downregulated and replaced by neurofilaments. Note: This description may include information from UniProtKB. Protein type: Cytoskeletal protein Cellular Component: intermediate filament cytoskeleton; cytoplasm; intermediate filament; intracellular Molecular Function: intermediate filament binding; structural molecule activity; CCR5 chemokine receptor binding Biological Process: response to nutrient levels; response to drug; nervous system development; cell projection morphogenesis; embryonic camera-type eye development; positive regulation of intermediate filament depolymerization; neuron differentiation; negative regulation of catalytic activity; response to ionizing radiation; brain development; G2/M transition of mitotic cell cycle; negative regulation of protein binding; negative regulation of apoptosis Reference #:  P21263 (UniProtKB) Alt. Names/Synonyms: Nes; NEST; Nestin Gene Symbols: Nes Molecular weight: 208,797 Da Basal Isoelectric point: 4.3  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below nestin

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			rat ► Hide Isoforms
0	1		Y22	LNRRLEAYLTRVKTL
0	1		K27	EAYLTRVKTLEEQNQ
0	6		K74	VDQRWREKLEAEVQR
0	13		T105	VRLARERTVQEAACS
0	7		K120	RRALEAEKNARGWLS
0	1		A158	LNAQAACAPRRPPAP
0	2		S169	PPAPPHGSPVRAPEV
0	7		K260	DRLQATDKFQLAVEA
0	6		K272	VEALEQEKQGLQSQI
0	2		S312	TLLEAENSRLQTPGR
1	4		T316	AENSRLQTPGRGSQA
0	3		S321	LQTPGRGSQASLGFL
0	10		Q322	QTPGRGSQASLGFLD
0	11		G326	RGSQASLGFLDPKLK
0	3		K331	SLGFLDPKLKPNFLG
0	17		I339	LKPNFLGIPEDQYLG
0	2		S347	PEDQYLGSVLPALSP
0	4		S353	GSVLPALSPTSFPSP
0	2		S356	LPALSPTSFPSPLPN
0	3		S359	LSPTSFPSPLPNTLE
0	1		T367	PLPNTLETPVTAFLK
0	1		T383	QEFLQARTPTLASTP
0	3		T385	FLQARTPTLASTPIP
0	2		T389	RTPTLASTPIPPISE
0	5		C399	PPISEAPCPPNAEVR
0	1		F450	GGKQQGHFPDDLTSL
0	10		N462	TSLATTLNPHHPTLE
0	1		P466	TTLNPHHPTLEAKDG
0	3		S475	LEAKDGESSGSRVSS
0	1		S476	EAKDGESSGSRVSSI
0	1		S481	ESSGSRVSSIFQEDE
0	3		S482	SSGSRVSSIFQEDEG
0	7		K497	QIWELVEKEADIEVK
0	1		K504	KEADIEVKVENSSAQ
0	1		E521	QESGLDTEETQDSQG
0	6		A537	LQKETLKALGEEPLM
0	1		S562	GKENCNSSTEGHLGT
0	1		L567	NSSTEGHLGTLEGPE
0	1		G572	GHLGTLEGPEKEKQI
0	1		K582	KEKQIPLKSLEEKNV
0	1		K587	PLKSLEEKNVESEKT
0	1		S591	LEEKNVESEKTLENG
0	1		K593	EKNVESEKTLENGVP
0	3		S620	TEDQELMSPKGTLKR
0	11		S685	EDQSFPRSPEEEDQE
0	2		R695	EEDQEACRPLQKENQ
0	1		P696	EDQEACRPLQKENQE
0	3		S726	IEKESQESLRSPEEE
0	4		S729	ESQESLRSPEEEDQE
0	2		S814	IEKESQESLRSPEEE
0	3		S817	ESQESLRSPEEEDQE
0	2		S855	ERLIEKESQESLKSP
0	2		S858	IEKESQESLKSPEEN
0	8		S861	ESQESLKSPEENQRI
0	10		S903	RNQRPLRSLEVEEEE
0	1		-	gap
0	1		-	gap
0	1		S921	VKPLEKVSQDSLGSL
0	5		S924	LEKVSQDSLGSLAEE
0	3		S927	VSQDSLGSLAEENVQ
0	3		P935	LAEENVQPLRYLEED
0	2		S960	KTHKSLGSLEDRNGD
0	1		S999	VNHLEKESQEFSRSS
0	4		S1005	ESQEFSRSSEEEERV
0	4		S1016	EERVMERSLEGENHE
0	4		S1049	ESQDSGKSLEDESQE
0	8		P1060	ESQETFGPLEKENAE
0	9		S1071	ENAESLRSLAGQDQE
0	1		A1099	AVGNEQMAVSPPEKV
0	1		P1113	VDPELPKPLGNDQEI
0	2		G1139	LVSLKEKGIETVKSL
0	3		K1144	EKGIETVKSLETEII
0	1		S1145	KGIETVKSLETEIIE
0	2		T1148	ETVKSLETEIIEPLE
0	4		P1153	LETEIIEPLETAEED
0	1		-	gap
0	2		T1156	EIIEPLETAEEDLER
0	2		R1163	TAEEDLERRKsIDTQ
0	17		S1166-p	EDLERRKsIDTQEPL
0	8		T1169	ERRKsIDTQEPLWST
0	2		S1175	DTQEPLWSTEVARET
0	3		T1205	DENRETLTSLEKESQ
0	2		-	gap
0	1		S1216	KESQELSSLGKWNVE
0	1		-	gap
0	1		-	gap
0	3		-	gap
0	1		-	gap
0	1		E1227	WNVETRVEDSQQCLQ
0	1		S1229	VETRVEDSQQCLQVE
0	6		E1241	QVEEGLQEEQHQESL
0	7		H1244	EGLQEEQHQESLREV
0	1		S1247	QEEQHQESLREVKQE
0	8		-	gap
0	1		S1258	VKQELPSSGNQQRWE
0	1		N1260	QELPSSGNQQRWEDV
0	1		A1277	GKAVGQEAPLATTGV
0	1		S1322	GEAWSLGSSEPKEQR
0	1		S1369	AQAGEQDSIEVTLGL
0	2		S1457	ECQGHEESESMEGWE
0	3		S1510	PKLLEPCSPIPILTD
0	1		N1547	EALERVENEPEFGLG
0	1		G1566	GLQDWEEGREESEAD
0	7		S1570	WEEGREESEADDLGE
1	0		T1583	GETLPDSTPLGLYLR
0	4		S1591	PLGLYLRSPASPKWD
0	5		S1594	LYLRSPASPKWDLAG
0	3		-	gap
0	2		S1686	CWDQGGESDGFADEE
0	10		S1695	GFADEEESGEEGEEE
0	1		A1720	AQWWGSGASGGGCKV
0	1		S1721	QWWGSGASGGGCKVQ
0	2		-	gap
0	2		-	gap
0	1		-	gap
0	2		-	gap
0	1		S1765	VPALEMVSQDSAEPS
0	1		S1768	LEMVSQDSAEPSGSE
0	3		S1772	SQDSAEPSGSEESES
0	2		S1774	DSAEPSGSEESESAS
0	1		S1777	EPSGSEESESASLEG
0	5		-	gap
0	2		-	gap
0	1		V1861	QEVGALKVPLVASPV
0	9		S1866	LKVPLVASPVHLGPS
0	1		K1877	LGPSQPLKFTLSGVD
0	1		S1887	LSGVDGDSWSSGED_
0	8		S1889	GVDGDSWSSGED___
0	8		S1890	VDGDSWSSGED____

	nestin iso2
Y22	LNRRLEAYLTRVKTL
K27	EAYLTRVKTLEEQNQ
K74	VDQRWREKLEAEVQR
T105	VRLARERTVQEAACS
K120	RRALEAEKNARGWLS
A158	LNAQAACAPRRPPAP
S169	PPAPPHGSPVRAPEV
K260	DRLQATDKFQLAVEA
K272	VEALEQEKQGLQSQI
S312	TLLEAENSRLQtPGR
T316-p	AENSRLQtPGRGSQA
S321	LQtPGRGSQASLGFL
Q322	QtPGRGSQASLGFLD
G326	RGSQASLGFLDPKLK
K331	SLGFLDPKLKPNFLG
I339	LKPNFLGIPEDQYLG
S347	PEDQYLGSVLPALSP
S353	GSVLPALSPTSFPSP
S356	LPALSPTSFPSPLPN
S359	LSPTSFPSPLPNTLE
T367	PLPNTLETPVTAFLK
T383	QEFLQARTPTLASTP
T385	FLQARTPTLASTPIP
T389	RTPTLASTPIPPISE
C399	PPISEAPCPPNAEVR
F450	GGKQQGHFPDDLTSL
N462	TSLATTLNPHHPTLE
P466	TTLNPHHPTLEAKDG
S475	LEAKDGESSGSRVSS
S476	EAKDGESSGSRVSSI
S481	ESSGSRVSSIFQEDE
S482	SSGSRVSSIFQEDEG
K497	QIWELVEKEADIEVK
K504	KEADIEVKVENSSAQ
E521	QESGLDTEETQDSQG
A537	LQKETLKALGEEPLM
S562	GKENCNSSTEGHLGT
L567	NSSTEGHLGTLEGPE
G572	GHLGTLEGPEKEKQI
K582	KEKQIPLKSLEEKNV
K587	PLKSLEEKNVESEKT
S591	LEEKNVESEKTLENG
K593	EKNVESEKTLENGVP
S620	TEDQELMSPKGTLKR
S685	EDQSFPRSPEEEDQE
R695	EEDQEACRPLQKENQ
P696	EDQEACRPLQKENQE
S726	IEKESQESLRSPEEE
S729	ESQESLRSPEEEDQE
-	gap
-	gap
S767	ERLIEKESQESLKSP
S770	IEKESQESLKSPEEN
S773	ESQESLKSPEENQRI
S815	RNQRPLRSLEVEEEE
-	gap
-	gap
S833	VKPLEKVSQDSLGSL
S836	LEKVSQDSLGSLAEE
S839	VSQDSLGSLAEENVQ
P847	LAEENVQPLRYLEED
S872	KTHKSLGSLEDRNGD
S911	VNHLEKESQEFSRSS
S917	ESQEFSRSSEEEERV
S928	EERVMERSLEGENHE
S961	ESQDSGKSLEDESQE
P972	ESQETFGPLEKENAE
S983	ENAESLRSLAGQDQE
A1011	AVGNEQMAVSPPEKV
P1025	VDPELPKPLGNDQEI
G1051	LVSLKEKGIETVKSL
K1056	EKGIETVKSLETEII
S1057	KGIETVKSLETEIIE
T1060	ETVKSLETEIIEPLE
P1065	LETEIIEPLETAEED
-	gap
T1068	EIIEPLETAEEDLER
R1075	TAEEDLERRKSIDTQ
S1078	EDLERRKSIDTQEPL
T1081	ERRKSIDTQEPLWST
S1087	DTQEPLWSTEVARET
T1117	DENRETLTSLEKESQ
-	gap
S1128	KESQELSSLGKWNVE
-	gap
-	gap
-	gap
-	gap
E1139	WNVETRVEDSQQCLQ
S1141	VETRVEDSQQCLQVE
E1153	QVEEGLQEEQHQESL
H1156	EGLQEEQHQESLREV
S1159	QEEQHQESLREVKQE
-	gap
S1170	VKQELPSSGNQQRWE
N1172	QELPSSGNQQRWEDV
A1189	GKAVGQEAPLATTGV
S1234	GEAWSLGSSEPKEQR
S1281	AQAGEQDSIEVTLGL
S1369	ECQGHEESESMEGWE
S1422	PKLLEPCSPIPILTD
N1459	EALERVENEPEFGLG
G1478	GLQDWEEGREESEAD
S1482	WEEGREESEADDLGE
T1495-p	GETLPDStPLGLYLR
S1503	PLGLYLRSPASPKWD
S1506	LYLRSPASPKWDLAG
-	gap
S1598	CWDQGGESDGFADEE
S1607	GFADEEESGEEGEEE
A1632	AQWWGSGASGGGCKV
S1633	QWWGSGASGGGCKVQ
-	gap
-	gap
-	gap
-	gap
S1677	VPALEMVSQDSAEPS
S1680	LEMVSQDSAEPSGSE
S1684	SQDSAEPSGSEESES
S1686	DSAEPSGSEESESAS
S1689	EPSGSEESESASLEG
-	gap
-	gap
V1773	QEVGALKVPLVASPV
S1778	LKVPLVASPVHLGPS
K1789	LGPSQPLKFTLSGVD
S1799	LSGVDGDSWSSGED_
S1801	GVDGDSWSSGED___
S1802	VDGDSWSSGED____

	human ► Hide Isoforms
Y22-p	LNRRLEAyLARVkAL
K27-u	EAyLARVkALEEQNE
K74-u	VDQRWREkHAAEVAR
T105-p	LRLARERtTEEVARN
K120-u	RRAVEAEkCARAWLS
A158	LNAQAACAPRCPAPP
P168	CPAPPRGPPAPAPEV
K259-u	ERLRATEkFQLAVEA
K271-u	VEALEQEkQGLQSQI
S311-p	TLLEAENsRLQtPGG
T315-p	AENsRLQtPGGGskT
S320-p	LQtPGGGskTSLsFQ
K321-u	QtPGGGskTSLsFQD
S325-p	GGskTSLsFQDPkLE
K330-u	SLsFQDPkLELQFPR
T338-p	LELQFPRtPEGRRLG
S346-p	PEGRRLGsLLPVLsP
S352-p	GsLLPVLsPTsLPsP
S355-p	LPVLsPTsLPsPLPA
S358-p	LsPTsLPsPLPATLE
T366	PLPATLETPVPAFLK
T382-p	QEFLQARtPtLAStP
T384-p	FLQARtPtLAStPIP
T388-p	RtPtLAStPIPPTPQ
S398-p	PPTPQAPsPAVDAEI
S459-p	QEASTGQsPEDHASL
S471-p	ASLAPPLsPDHsSLE
S475-p	PPLsPDHsSLEAKDG
S484-p	LEAKDGEsGGSRVFs
G485	EAKDGEsGGSRVFsI
F490	EsGGSRVFsICRGEG
S491-p	sGGSRVFsICRGEGE
K507-u	QIWGLVEkETAIEGk
K514-u	kETAIEGkVVSSLQQ
K532-u	EEEDLNRkEIQDSQV
S548-p	LEKETLKsLGEEIQE
-	gap
-	gap
-	gap
K558	EEIQESLKTLENQsH
-	gap
S564-p	LKTLENQsHETLERE
E566	TLENQsHETLERENQ
-	gap
S578-p	ENQECPRsLEEDLET
K587-u	EEDLETLksLEKENK
S588-p	EDLETLksLEKENKE
-	gap
-	gap
-	gap
-	gap
N632	LQSLQKENQELMKsL
L635	LQKENQELMKsLEGN
S638-p	ENQELMKsLEGNLET
S680-p	ENQEPLRsPEVGDEE
S702-p	ENQEPLRsLEDENkE
K708-u	RsLEDENkEAFRsLE
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
S713-p	ENkEAFRsLEKENQE
S746-p	ENHKSLRsLEEQDQE
T757-p	QDQETLRtLEKETQQ
S768-p	ETQQRRRsLGEQDQM
T776-p	LGEQDQMtLRPPEKV
S790-p	VDLEPLKsLDQEIAR
S814-p	LKSLKEEsVEAVksL
K819-u	EEsVEAVksLEtEIL
S820-p	EsVEAVksLEtEILE
T823-p	EAVksLEtEILEsLk
S828-p	LEtEILEsLksAGQE
K830-u	tEILEsLksAGQENL
S831-p	EILEsLksAGQENLE
T839-p	AGQENLEtLKsPEtQ
S842-p	ENLEtLKsPEtQAPL
T845-p	EtLKsPEtQAPLWtP
T851-p	EtQAPLWtPEEINQG
-	gap
S891-p	LEEENQEsLRsLGAW
S894-p	ENQEsLRsLGAWNLE
-	gap
-	gap
S905-p	WNLENLRsPEEVDkE
-	gap
K911-u	RsPEEVDkEsQRNLE
S913-p	PEEVDkEsQRNLEEE
K925-u	EEEENLGkGEyQESL
Y928-p	ENLGkGEyQESLRsL
S931	GkGEyQESLRsLEEE
S934-p	EyQESLRsLEEEGQE
S945	EGQELPQSADVQRWE
D947	QELPQSADVQRWEDT
S965-p	DQELAQEsPPGMAGV
S1016-p	PGEGHPEsPEPKEQR
S1079	APGGDQASPEVMLGS
S1175-p	PREGREEsEAEAPRG
T1224	VLVSPSPTYTPILED
S1261	EALGKVESEQEELGS
S1282	PQEEGEESREEsEED
S1286-p	GEESREEsEEDELGE
T1299	GETLPDSTPLGFYLR
S1307	PLGFYLRSPTsPRWD
S1310-p	FYLRSPTsPRWDPTG
S1347-p	EGLEAPPsEKEEGEE
S1409-p	AWDRDGEsDGFADEE
S1418-p	GFADEEEsGEEGEED
S1441-p	AGRWGPGssVGsLQA
S1442-p	GRWGPGssVGsLQAL
S1445-p	GPGssVGsLQALsss
S1450-p	VGsLQALsssQRGEF
S1451-p	GsLQALsssQRGEFL
S1452-p	sLQALsssQRGEFLE
S1489-p	KTALETEsQDsAEPs
S1492-p	LETEsQDsAEPsGsE
S1496-p	sQDsAEPsGsEEEsD
S1498-p	DsAEPsGsEEEsDPV
S1502-p	PsGsEEEsDPVSLER
S1577-p	VSEGDRGsPFQEEEG
S1585-p	PFQEEEGsALKtSWA
T1589-p	EEGsALKtSWAGAPV
A1594	LKtSWAGAPVHLGQG
K1605-u	LGQGQFLkFTQREGD
S1615-p	QREGDREsWssGED_
S1617-p	EGDREsWssGED___
S1618-p	GDREsWssGED____

	nestin iso2
Y22	LNRRLEAYLGRVKAL
K27	EAYLGRVKALEEQNE
K74	VDQRWREKHAAEVAR
T105	LRLARERTTEEVARN
K120	RRAVEAEKCARAWLS
A158	LNAQAACAPRLPAPP
P167	RLPAPPRPPAPAPEV
K258	ERLRATEKFQLAVEA
K270	VEALEQEKQGLQSQI
S310	TLLEAENSRLQTPGG
T314	AENSRLQTPGGGSKT
S319	LQTPGGGSKTSLSFQ
K320	QTPGGGSKTSLSFQD
S324	GGSKTSLSFQDPKLE
K329	SLSFQDPKLELQFPR
T337	LELQFPRTPEGRRLG
S345	PEGRRLGSLLPVLSP
S351	GSLLPVLSPTSLPSP
S354	LPVLSPTSLPSPLPA
S357	LSPTSLPSPLPATLE
T365	PLPATLETPVPAFLK
T381	QEFLQARTPTLASTP
T383	FLQARTPTLASTPIP
T387	RTPTLASTPIPPTPQ
S397	PPTPQAPSPAVDAEI
S458	QEASTGQSPEDHASL
S470	ASLAPPLSPDHSSLE
S474	PPLSPDHSSLEAKDG
S483	LEAKDGESGGSRVFS
G484	EAKDGESGGSRVFSI
F489	ESGGSRVFSICRGEG
S490	SGGSRVFSICRGEGE
K506	QIWGLVEKETAIEGK
K513	KETAIEGKVVSSLQQ
K531	EEEDLNRKEIQDSQV
S547	LEKETLKSLGEEIQE
-	gap
-	gap
-	gap
K557	EEIQESLKTLENQSH
-	gap
S563	LKTLENQSHETLERE
E565	TLENQSHETLERENQ
-	gap
S577	ENQECPRSLEEDLET
K586	EEDLETLKSLEKENK
S587	EDLETLKSLEKENKR
-	gap
-	gap
-	gap
-	gap
N631	LQSLQKENQELMKSL
L634	LQKENQELMKSLEGN
S637	ENQELMKSLEGNLET
S679	ENQEPLRSPEVGDEE
S701	ENQEPLRSLEDENKE
K707	RSLEDENKEAFRSLE
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
S712	ENKEAFRSLEKENQE
S745	ENHKSLRSLEEQDQE
T756	QDQETLRTLEKETQQ
S767	ETQQRRRSLGEQDQM
T775	LGEQDQMTLRPPEKV
S789	VDLEPLKSLDQEIAR
S813	LKSLKEESVEAVKSL
K818	EESVEAVKSLETEIL
S819	ESVEAVKSLETEILE
T822	EAVKSLETEILESLK
S827	LETEILESLKSAGQE
K829	TEILESLKSAGQENL
S830	EILESLKSAGQENLE
T838	AGQENLETLKSPETQ
S841	ENLETLKSPETQAPL
T844	ETLKSPETQAPLWTP
T850	ETQAPLWTPEEINKS
-	gap
-	gap
-	gap
S895-p	ESGIIEIsGsMEPGE
S897-p	GIIEIsGsMEPGEFE
-	gap
S906-p	EPGEFEIsRGVDKES
K911	EIsRGVDKESQRNLE
S913	sRGVDKESQRNLEEE
K925	EEEENLGKGEYQESL
Y928	ENLGKGEYQESLRSL
S931	GKGEYQESLRSLEEE
S934	EYQESLRSLEEEGQE
S945	EGQELPQSADVQRWE
D947	QELPQSADVQRWEDT
S965	DQELAQESPPGMAGV
N1016	PGEGHPENPEPKEQR
S1079	APGGDQASPEVMLGS
S1175	PREGREESEAEAPRG
T1224	VLVSPSPTYTPILED
S1260-p	AEAGKVEsEQEELGS
S1281-p	LQEEGEEsREESEED
S1285	GEEsREESEEDELGE
T1298	GETLPDSTPLGFYLR
S1306	PLGFYLRSPTSPRWT
S1309	FYLRSPTSPRWTPLE
S1344	SEGLEEPSEKEEGEE
S1406	AWDRDGESDGFADEE
S1415	GFADEEESGEEGEED
S1438	AGRWGPGSSVGSLQA
S1439	GRWGPGSSVGSLQAL
S1442	GPGSSVGSLQALSSS
S1447	VGSLQALSSSQRGEF
S1448	GSLQALSSSQRGEFL
S1449	SLQALSSSQRGEFLE
S1486	KTALETESQDSAEPS
S1489	LETESQDSAEPSGSE
S1493	SQDSAEPSGSEEESD
S1495	DSAEPSGSEEESDPV
S1499	PSGSEEESDPVSLER
S1574	VSEGDRGSPFQEEEG
S1582	PFQEEEGSALKRSSA
R1586	EEGSALKRSSAGAPV
A1591	LKRSSAGAPVHLGQG
K1602	LGQGQFLKFTQREGD
S1612	QREGDRESWSSGED_
S1614	EGDRESWSSGED___
S1615	GDRESWSSGED____

	mouse
Y22	LNRRLEAYLTRVKTL
K27	EAYLTRVKTLEEQNQ
K74	VDQRWREKHEAEVQR
T105-p	VRLARERtIEEAACS
K120	RRALEAEKNARGWLS
T158-p	LNAQAACtPRRPPAP
S169-p	PPAPAHAsPIRAPEV
K260	DRLQATEKFQLAVEA
K272	VEALEQEKQGLQSQI
S312	TLLEAENSRLQTPGR
T316	AENSRLQTPGRSSQA
S321	LQTPGRSSQASLGFP
Q322	QTPGRSSQASLGFPD
G326	RSSQASLGFPDPKLK
K331	SLGFPDPKLKLHFLG
I339	LKLHFLGIPEDQHLG
S347	PEDQHLGSVLPVLSP
S353	GSVLPVLSPTSFSsP
S356	LPVLSPTSFSsPLPN
S359-p	LSPTSFSsPLPNTLE
T367-p	PLPNTLEtPVTAFLK
T383	QEFLKARTPtLASTP
T385-p	FLKARTPtLASTPIP
T389	RTPtLASTPIPPMSE
Y399-p	PPMSEAPyPKNAEVR
F453	GGEQPDHFPDDPTSL
N465	TSLAPPLNPHHSILE
S469	PPLNPHHSILEAKDR
S478-p	LEAKDREssESRVss
S479-p	EAKDREssESRVssI
S484-p	EssESRVssIFQEEE
S485-p	ssESRVssIFQEEEG
K500	QIWELVKKEAATEVK
K507	KEAATEVKVENSLAQ
E524	QESGLDTEEIQDSQG
A540	LQMETLEALGDEPLM
S565-p	GKENCNSsIEENsGT
S570-p	NSsIEENsGTVKsPE
S575-p	ENsGTVKsPEKEKQT
K585-a	KEKQTPLkSLEEkNV
K590-a	PLkSLEEkNVEAEkT
A594	LEEkNVEAEkTLENG
K596-a	EkNVEAEkTLENGVL
S623-p	MEDQELMsPEHTLET
S688-p	EDQRFPRsPEEDQQA
R697	EEDQQAFRPLEKENQ
P698	EDQQAFRPLEKENQE
S728-p	IEKERQEsLKsPEEE
S731-p	ERQEsLKsPEEEDQQ
S772-p	IEKERQEsLKsPEEE
S775-p	ERQEsLKsPEEEDQQ
S813-p	ERLVEKEsQEsLKsP
S816-p	VEKEsQEsLKsPEEE
S819-p	EsQEsLKsPEEEDQR
S862-p	KNQRPLRsLEVEEEE
-	gap
-	gap
S880-p	VKPLEKVsQVsLEsL
S883-p	LEKVsQVsLEsLEKE
S886-p	VsQVsLEsLEKENVQ
S894-p	LEKENVQsPRYLEED
S919-p	KTHEILGsLEDRNGE
S957-p	VNHLEKEsQEFLRsP
S963-p	EsQEFLRsPEAEEEE
S977-p	EEQVMVRsLEGENHD
S1010-p	ESQDSRKsLEDESQE
S1021-p	ESQETFGsLEKENLE
S1032	ENLESLRSLAGQDQE
T1060	AVEDEQMTVNPPEKV
P1074	VDPELPKPLRNDQEV
G1100	LVSLNEGGMETVKSS
K1105	EGGMETVKSSETENI
S1106	GGMETVKSSETENIE
T1109	ETVKSSETENIEsLE
S1114-p	SETENIEsLEtVGEC
-	gap
T1117-p	ENIEsLEtVGECLGR
R1124	tVGECLGRRKsVDtQ
S1127-p	ECLGRRKsVDtQEPL
T1130-p	GRRKsVDtQEPLWST
S1136	DtQEPLWSTEVTSET
T1166-p	DENQEVLtPLERESQ
-	gap
S1177	RESQELRSLGKWNPE
-	gap
-	gap
S1188-p	WNPETVEsPGGVEDS
-	gap
E1193	VEsPGGVEDSQQCLE
S1195	sPGGVEDSQQCLEVE
R1207	EVEEGPEREQHQEsL
H1210	EGPEREQHQEsLRsL
S1213-p	EREQHQEsLRsLGEV
S1216-p	QHQEsLRsLGEVEWE
S1227-p	VEWELPGsGsQQRWE
S1229-p	WELPGsGsQQRWEDV
A1245	EDGEGQEASLGATGV
S1290	GEAWSLGSSEPKEQR
S1342-p	AQAGEQDsVEVTLGL
S1430	ECKGWEESGEGWGEE
S1481-p	PKLLEPCsPIPILTD
D1518	EALGRVEDEPEFGRG
G1537	GLQDWEEGREDsEAD
S1541-p	WEEGREDsEADELGE
T1554	GETLPDSTPLGLYLK
S1562-p	PLGLYLKsPAsPKWE
S1565-p	LYLKsPAsPKWEQAG
-	gap
S1656	CWDQGGESDGFADEE
S1665	GFADEEESGEEGEEE
P1691	TQWWGPGPSGGGVKV
S1692	QWWGPGPSGGGVKVQ
-	gap
-	gap
-	gap
-	gap
S1738	VTALETVSQDSAEPS
S1741	LETVSQDSAEPSGSE
S1745	SQDSAEPSGSEGSES
S1747	DSAEPSGSEGSESAS
S1750	EPSGSEGSESASLEG
-	gap
-	gap
A1832	QEQGTLKAPLVGsPV
S1837-p	LKAPLVGsPVHLGPS
K1848	LGPSQPLKFTLSGVD
S1858-p	LSGVDGDsWssGED_
S1860-p	GVDGDsWssGED___
S1861-p	VDGDsWssGED____

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