an ubiquitous protein kinase of the CK2 family. Exists as a tetramer composed of two catalytic subunits, alpha and alpha-prime, and two regulatory beta subunits. The beta subunits undergo autophosphorylation. The isoforms are rarely specified in publications. Two splice variant isoforms have been found. Participates in Wnt signaling. Phosphorylates E2 ubiquitin conjugating enzyme UBC3B inducing its interaction with beta-TRCp and enhancing beta-catenin degradation. May control IkB-alpha and p27Kip1 degradation. component of a CK2-SPT16-SSRP1 complex composed of SSRP1, PT16 CK2-A1, CK2-A2 and CK2-B the complex associating following UV irradiation. Interacts with RNPS1. Mouse transgene causes mammary gland hyperplasia and lymphoma, and activation by bovine parasites leads to fatal lymphoproliferation. Expression and activity are elevated in lung tumors and breast tumors. Antisense drives apoptosis of tumor cell lines and xenografts. Involved in DNA break repair by phosphorylation of scaffold protein XRCC1, phosphorylation of BRCA1, and phosphorylation of p53 in response to UV irradiation. Drosophila CK2 (Timekeeper) is involved in circadian regulation. Phosphorylates and binds to a major component of the inclusion bodies seen in Parkinson?s patients. Inhibitors: 4,5,6,7-tetrabromobenzotriazole (TBB). Note: This description may include information from UniProtKB.
Protein type: EC 220.127.116.11; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; CK2 family
Cellular Component: Sin3 complex; protein kinase CK2 complex; NuRD complex; PcG protein complex; nucleus
Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; protein phosphatase regulator activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; beta-catenin binding; protein N-terminus binding; kinase activity; ATP binding; protein kinase activity
Biological Process: Wnt receptor signaling pathway; transcription, DNA-dependent; apoptosis; protein amino acid autophosphorylation; rhythmic process; negative regulation of caspase activity; cell cycle; protein amino acid phosphorylation; positive regulation of cell growth; regulation of transcription, DNA-dependent; regulation of catalytic activity; positive regulation of cell proliferation; positive regulation of protein catabolic process; phosphorylation; positive regulation of Wnt receptor signaling pathway
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.