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IkB-zeta (human)

Overview IkB-zeta Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF- kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis. Interacts with NFKB1/p50. Interacts with RELA. By TNF, IL1/interleukin-1 and bacterial lipopolysaccharides (LPS). Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: DNA binding protein Cellular Component: nucleus Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; inflammatory response Reference #:  Q9BYH8 (UniProtKB) Alt. Names/Synonyms: FLJ30225; FLJ34463; I-kappa-B-zeta; Ikappa B-zeta variant 3; IkappaB-zeta; IkappaBzeta; IkB-zeta; IKBZ; IL-1 inducible nuclear ankyrin-repeat protein; INAP; MAIL; Molecule possessing ankyrin repeats induced by lipopolysaccharide; NF-kappa-B inhibitor zeta; NFKBIZ; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta Gene Symbols: NFKBIZ Molecular weight: 78,061 Da Basal Isoelectric point: 6.15  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  T Cell Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below IkB-zeta

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S170-p	GKRKGPDsLsDGPAC
0	1		S172-p	RKGPDsLsDGPACKR
0	1		K534	QVLQAIQKGAVGSNQ
0	1		S590	ELLLKNKSLVDTIKC
0	1		T594	KNKSLVDTIKCLIQM
0	1		T664	ASLQYRLTQLDAVRL

	mouse
P169	GKRKGPDPLSDGPVC
S171	RKGPDPLSDGPVCKR
K544-a	QVLQAIQkGAVRSNQ
S600-p	DLLLRNKsLVDtIKC
T604-p	RNKsLVDtIKCLIQM
T674-p	ASLQYRVtQLDAVRL

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