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Protein Page:
IkB-zeta (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IkB-zeta Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF- kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis. Interacts with NFKB1/p50. Interacts with RELA. By TNF, IL1/interleukin-1 and bacterial lipopolysaccharides (LPS). Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein
Cellular Component: nucleus
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; inflammatory response
Reference #:  Q9BYH8 (UniProtKB)
Alt. Names/Synonyms: FLJ30225; FLJ34463; I-kappa-B-zeta; Ikappa B-zeta variant 3; IkappaB-zeta; IkappaBzeta; IkB-zeta; IKBZ; IL-1 inducible nuclear ankyrin-repeat protein; INAP; MAIL; Molecule possessing ankyrin repeats induced by lipopolysaccharide; NF-kappa-B inhibitor zeta; NFKBIZ; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
Gene Symbols: NFKBIZ
Molecular weight: 78,061 Da
Basal Isoelectric point: 6.15  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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IkB-zeta

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S170-p GKRKGPDsLsDGPAC
0 1 S172-p RKGPDsLsDGPACKR
0 1 P190 LHSQFLTPPQTPTPG
0 1 T193 QFLTPPQTPTPGESM
0 1 N241 TVQVSWLNPVVVPQS
0 1 S249 PVVVPQSSPAEQCQD
0 1 S264 FHGGQVFSPPQKCQP
0 1 K534 QVLQAIQKGAVGSNQ
0 1 S590 ELLLKNKSLVDTIKC
0 1 T594 KNKSLVDTIKCLIQM
0 1 T664 ASLQYRLTQLDAVRL
  mouse

 
P169 GKRKGPDPLSDGPVC
S171 RKGPDPLSDGPVCKR
S189-p LPSHFVTsPQtPTPG
T192-p HFVTsPQtPTPGESM
S240-p TVQVSWMsPTVPQNs
S247-p sPTVPQNsPRDQCQD
S262-p FHGGQAFsPPQKYQP
K544-ac QVLQAIQkGAVRSNQ
S600-p DLLLRNKsLVDtIKC
T604-p RNKsLVDtIKCLIQM
T674-p ASLQYRVtQLDAVRL
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