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Protein Page:
TBKBP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TBKBP1 Adapter protein which constitutively binds TBK1 and IKBKE and may play a role in antiviral innate immunity. Homodimer. May form a heterodimer with NAP1. Interacts with TKB1 and IKBKE. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Molecular Function: protein binding
Biological Process: innate immune response
Reference #:  A7MCY6 (UniProtKB)
Alt. Names/Synonyms: KIAA0775; ProSAPiP2; SINTBAD; TANK-binding kinase 1-binding protein 1; TBK1 binding protein 1; TBK1-binding protein 1; TBKB1; TBKBP1
Gene Symbols: TBKBP1
Molecular weight: 67,702 Da
Basal Isoelectric point: 5.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TBKBP1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S10-p SMFEDDIsILtQEAL
0 1 T13-p EDDIsILtQEALGPS
0 1 Y48-p HFALITAyGDIKERL
0 1 Y76 LKVYEIKYPLISDFG
0 1 S97 LYEIKDGSLLEVEKV
0 1 S105 LLEVEKVSLQQRLNQ
0 1 S184-p DAAFSNLsPPPAPAP
0 1 K262-ub ERLQGELkQLQETRA
0 3 S335-p RSGGQRHsPLSQRHS
0 1 S349-p SPAPQCPsPsPPARA
0 1 S351-p APQCPsPsPPARAAP
0 1 S365-p PPCPPCQsPVPQRRs
0 4 S372-p sPVPQRRsPVPPCPs
0 3 S379-p sPVPPCPsPQQRRsP
0 4 S385-p PsPQQRRsPAsPsCP
0 3 S388-p QQRRsPAsPsCPsPV
0 1 S390-p RRsPAsPsCPsPVPQ
0 2 S393-p PAsPsCPsPVPQRRs
0 3 S400-p sPVPQRRsPVPPsCQ
0 1 S405-p RRsPVPPsCQSPSPQ
0 3 S415-p SPSPQRRsPVPPSCP
0 6 S504-p YGPGRPLsPRRAFEG
0 1 S521-p LRFEKQPsEEDEWAV
0 1 S534-p AVPTSPPsPEVGTIR
0 1 S581 LLMETVGSDIRSCPL
  mouse

 
S10 SMFEDDISILTQEAL
T13 EDDISILTQEALGPS
Y48 HFALITAYGDIKERL
Y76-p LKVYEIKyPLITDFG
S97-p LYELKDGsLLEVEKV
S105-p LLEVEKVsLQQRLNQ
S184 DAAFSSLSPPAVPAS
K263 ERLQGELKQLQETRA
S336-p RNAGQRHsPLSQRHS
S350 SPAPACPSPSPPARP
S352 APACPSPSPPARPPP
S365 PPCAPCQSPAAQRRs
S372-p SPAAQRRsPVPPCPs
S379-p sPVPPCPsPQQRRsP
S385-p PsPQQRRsPASPSCP
S388 QQRRsPASPSCPsPV
S390 RRsPASPSCPsPVPQ
S393-p PASPSCPsPVPQRRs
S400-p sPVPQRRsPVPPSCQ
S405 RRsPVPPSCQSPSPQ
S415-p SPSPQRRsPVPPSCP
S500-p ELYGRPLsPRRAFEG
S517 LRFEKQPSEEEEWAM
S530 AMPASPPSPEAGTIR
S577-p LLMETVGsDIRSCPL
  rat

 
S10 SMFEDDISILTQEAL
T13 EDDISILTQEALGPS
Y48 HFALITAYGDIKERL
Y76 LKVYEIKYPLITDFG
S97 LYEIKDGSLLEVEKV
S105 LLEVEKVSLQQRLNQ
S184 DAAFSSLSPPAVPAT
K263 ERLQGELKQLQETRA
S336 RNAGQRHSPLSQRHS
S350 SPAPACPSPSPPARP
S352 APACPSPSPPARPPP
S365 PPCAPCQSPAAQRRS
S372 SPAAQRRSPVPPCPS
S379 SPVPPCPSPQQRRSP
S385 PSPQQRRSPASPSCP
S388 QQRRSPASPSCPSPV
S390 RRSPASPSCPSPVPQ
S393 PASPSCPSPVPQRRS
S400 SPVPQRRSPVPPSCQ
S405 RRSPVPPSCQSPSPQ
S415 SPSPQRRSPVPPSCP
S502 YGPGRPLSPRRAFEG
S519 LRFEKQPSEEEEWAM
S532 AMPASPPSPEASTIR
S579 LLMETVGSDIRSCPL
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