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Protein Page:
STXBP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
STXBP1 may participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Vesicle protein
Cellular Component: protein complex; mitochondrion; cytoplasm; plasma membrane; cytosol
Molecular Function: identical protein binding; protein domain specific binding; SNARE binding; syntaxin binding; syntaxin-1 binding; protein N-terminus binding; protein kinase binding
Biological Process: positive regulation of calcium ion-dependent exocytosis; synaptic transmission; protein transport; axon target recognition; platelet degranulation; protein stabilization; glutamate secretion; synaptic vesicle maturation; neurotransmitter secretion; energy reserve metabolic process; neuromuscular synaptic transmission; negative regulation of neuron apoptosis; negative regulation of synaptic transmission, GABAergic; regulation of insulin secretion; vesicle docking during exocytosis
Reference #:  P61764 (UniProtKB)
Alt. Names/Synonyms: FLJ37475; MUNC18-1; N-Sec1; neuronal SEC1; NSEC1; p67; Protein unc-18 homolog 1; Protein unc-18 homolog A; RBSEC1; STXB1; STXBP1; syntaxin binding protein 1; Syntaxin-binding protein 1; Unc-18A; UNC18; Unc18-1; UNC18A
Gene Symbols: STXBP1
Molecular weight: 67,569 Da
Basal Isoelectric point: 6.5  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STXBP1

Protein Structure Not Found.


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Sites Implicated In
exocytosis, inhibited: T574‑p
molecular association, regulation: Y145‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K13 LKAVVGEKIMHDVIK
0 2 K20 KIMHDVIKKVKKKGE
0 1 S42 QLSMRMLSSCCKMTD
0 1 S43 LSMRMLSSCCKMTDI
0 1 K92 HSLISDFKDPPTAKY
0 7 K92 HSLISDFKDPPTAKY
0 2 K98 FKDPPTAKYRAAHVF
0 1 T107 RAAHVFFTDSCPDAL
0 2 K120 ALFNELVKSRAAKVI
0 3 K120 ALFNELVKSRAAKVI
0 1 S142 IAFLPYESQVySLDS
1 1 Y145-p LPYESQVySLDSADS
0 1 S146 PYESQVySLDSADSF
0 4 K184 ATLCATLKEYPAVRY
0 1 K196 VRYRGEYKDNALLAQ
0 2 K208-ub LAQLIQDkLDAYKAD
0 1 K225 TMGEGPDKARSQLLI
0 1 S269 DVYKYETSGIGEARV
0 3 K294 LWIALRHKHIAEVSQ
3 0 S306 VSQEVTRSLKDFSSS
0 3 K308 QEVTRSLKDFSSSKR
5 0 S313 SLKDFSSSKRMNTGE
0 12 K321 KRMNTGEKTTMRDLS
0 1 K321-m3 KRMNTGEkTTMRDLS
0 1 S345 QKELSKYSTHLHLAE
0 1 T346 KELSKYSTHLHLAED
0 7 K364 HYQGTVDKLCRVEQD
0 1 K382 GTDAEGEKIKDPMRA
0 5 Y411 KIRIILLYIFLKNGI
0 1 S454-p GVPIVTDstLRRRSK
0 3 T455-p VPIVTDstLRRRSKP
0 207 Y473-p ERISEQTyQLSRWTP
1 0 T479 TyQLSRWTPIIKDIM
0 2 K483 SRWTPIIKDIMEDtI
0 1 T489-p IKDIMEDtIEDKLDT
0 2 K493 MEDtIEDKLDTKHYP
0 1 K497 IEDKLDTKHYPYIST
0 6 K497 IEDKLDTKHYPYIST
0 1 Y501 LDTKHYPYISTRSSA
0 1 S507 PYISTRSSAsFSTTA
0 8 S509-p ISTRSSAsFSTTAVS
0 2 S511 TRSSAsFSTTAVSAR
0 1 T512 RSSAsFSTTAVSARY
0 4 S516 sFSTTAVSARYGHWH
2 0 T574-p IGSTHILtPQKLLDT
0 1 T581 tPQKLLDTLKKLNkT
0 1 K587-ub DTLKKLNkTDEEIss
0 1 T588 TLKKLNkTDEEIss_
0 5 S593-p NkTDEEIss______
0 5 S594-p kTDEEIss_______
0 1 - gap
0 4 - gap
  mouse

► Hide Isoforms
 
K13-ub LKAVVGEkIMHDVIK
K20 kIMHDVIKKVKKKGE
S42-p QLSMRMLssCCKMTD
S43-p LSMRMLssCCKMTDI
K92-ac HSLISDFkDPPTAKY
K92-ub HSLISDFkDPPTAKY
K98 FkDPPTAKYRAAHVF
T107-p RAAHVFFtDSCPDAL
K120 ALFNELVKSRAAKVI
K120-ub ALFNELVkSRAAKVI
S142-p IAFLPYEsQVysLDS
Y145-p LPYEsQVysLDSADS
S146-p PYEsQVysLDSADSF
K184-ub ATLCATLkEYPAVRY
K196-ub VRYRGEYkDNALLAQ
K208-ub LAQLIQDkLDAYKAD
K225-ub TMGEGPDkARSQLLI
S269-p DVYKYETsGIGEARV
K294-ub LWIALRHkHIAEVSQ
S306 VSQEVTRSLkDFSSS
K308-ub QEVTRSLkDFSSSKR
S313 SLkDFSSSKRMNTGE
K321-ub KRMNTGEkTTMRDLS
K321 KRMNTGEKTTMRDLS
S345-p QKELSKYstHLHLAE
T346-p KELSKYstHLHLAED
K364-ub HYQGTVDkLCRVEQD
K382-ub GTDAEGEkIKDPMRA
Y411 KIRIILLYIFLKNGI
S454-p GVPIVTDstLRRRSK
T455-p VPIVTDstLRRRSKP
Y473-p ERISEQTyQLSRWtP
T479-p TyQLSRWtPIIkDIM
K483-ub SRWtPIIkDIMEDTI
T489 IkDIMEDTIEDKLDT
K493 MEDTIEDKLDTkHYP
K497 IEDKLDTKHYPyIST
K497-ub IEDKLDTkHYPyIST
Y501-p LDTkHYPyISTRSsA
S507-p PyISTRSsAsFstTA
S509-p ISTRSsAsFstTAVs
S511-p TRSsAsFstTAVsAR
T512-p RSsAsFstTAVsARY
S516-p sFstTAVsARYGHWH
T574 IGSTHILTPQKLLDt
T581-p TPQKLLDtLKKLNKt
K587 DtLKKLNKtDEEIss
T588-p tLKKLNKtDEEIss_
S593-p NKtDEEIss______
S594-p KtDEEIss_______
- gap
- gap
  STXBP1 iso2  
K13 LKAVVGEKIMHDVIK
K20 KIMHDVIKKVKKKGE
S42 QLSMRMLSSCCKMTD
S43 LSMRMLSSCCKMTDI
K92 HSLISDFKDPPTAKY
K92 HSLISDFKDPPTAKY
K98 FKDPPTAKYRAAHVF
T107 RAAHVFFTDSCPDAL
K120 ALFNELVKSRAAKVI
K120 ALFNELVKSRAAKVI
S142 IAFLPYESQVYSLDS
Y145 LPYESQVYSLDSADS
S146 PYESQVYSLDSADSF
K184 ATLCATLKEYPAVRY
K196 VRYRGEYKDNALLAQ
K208 LAQLIQDKLDAYKAD
K225 TMGEGPDKARSQLLI
S269 DVYKYETSGIGEARV
K294 LWIALRHKHIAEVSQ
S306 VSQEVTRSLKDFSSS
K308 QEVTRSLKDFSSSKR
S313 SLKDFSSSKRMNTGE
K321 KRMNTGEKTTMRDLS
K321 KRMNTGEKTTMRDLS
S345 QKELSKYSTHLHLAE
T346 KELSKYSTHLHLAED
K364 HYQGTVDKLCRVEQD
K382 GTDAEGEKIKDPMRA
Y411 KIRIILLYIFLKNGI
S454 GVPIVTDSTLRRRSK
T455 VPIVTDSTLRRRSKP
Y473-p ERISEQTyQLSRWTP
T479 TyQLSRWTPIIKDIM
K483 SRWTPIIKDIMEDTI
T489 IKDIMEDTIEDKLDT
K493 MEDTIEDKLDTKHYP
K497 IEDKLDTKHYPYIST
K497 IEDKLDTKHYPYIST
Y501 LDTKHYPYISTRSSA
S507 PYISTRSSASFSTTA
S509 ISTRSSASFSTTAVS
S511 TRSSASFSTTAVSAR
T512 RSSASFSTTAVSARY
S516 SFSTTAVSARYGHWH
T574 IGSTHILTPTKFLMD
- gap
- gap
- gap
- gap
- gap
S590-p RHPDFREsSRVsFED
S594-p FREsSRVsFEDQAPT
  rat

► Hide Isoforms
 
K13 LKAVVGEKIMHDVIk
K20-ac KIMHDVIkKVKKKGE
S42 QLSMRMLSSCCKMTD
S43 LSMRMLSSCCKMTDI
K92 HSLISDFKDPPTAkY
K92-ub HSLISDFkDPPTAkY
K98-ac FkDPPTAkYRAAHVF
T107 RAAHVFFTDSCPDAL
K120-ac ALFNELVkSRAAKVI
K120-ub ALFNELVkSRAAKVI
S142 IAFLPYESQVYSLDS
Y145 LPYESQVYSLDSADS
S146 PYESQVYSLDSADSF
K184-ub ATLCATLkEYPAVRY
K196 VRYRGEYKDNALLAQ
K208 LAQLIQDKLDAYKAD
K225 TMGEGPDKARSQLLI
S269 DVYKYETSGIGEARV
K294-ub LWIALRHkHIAEVSQ
S306-p VSQEVTRsLkDFSSs
K308-ub QEVTRsLkDFSSsKR
S313-p sLkDFSSsKRMNTGE
K321-ub KRMNTGEkTTMRDLS
K321 KRMNTGEKTTMRDLS
S345 QKELSKYSTHLHLAE
T346 KELSKYSTHLHLAED
K364-ub HYQGTVDkLCRVEQD
K382 GTDAEGEKIKDPMRA
Y411-p KIRIILLyIFLKNGI
S454 GVPIVTDSTLRRRSK
T455 VPIVTDSTLRRRSKP
Y473-p ERISEQTyQLSRWTP
T479 TyQLSRWTPIIkDIM
K483-ub SRWTPIIkDIMEDTI
T489 IkDIMEDTIEDkLDT
K493-ub MEDTIEDkLDTkHYP
K497-ac IEDkLDTkHYPYIST
K497-ub IEDkLDTkHYPYIST
Y501 LDTkHYPYISTRSSA
S507 PYISTRSSASFSTTA
S509 ISTRSSASFSTTAVS
S511 TRSSASFSTTAVSAR
T512 RSSASFSTTAVSARY
S516 SFSTTAVSARYGHWH
T574-p IGSTHILtPQKLLDT
T581 tPQKLLDTLKKLNKT
K587 DTLKKLNKTDEEISS
T588 TLKKLNKTDEEISS_
S593 NKTDEEISS______
S594 KTDEEISS_______
- gap
- gap
  STXBP1 iso2  
K13 LKAVVGEKIMHDVIK
K20 KIMHDVIKKVKKKGE
S42 QLSMRMLSSCCKMTD
S43 LSMRMLSSCCKMTDI
K92 HSLISDFKDPPTAKY
K92 HSLISDFKDPPTAKY
K98 FKDPPTAKYRAAHVF
T107 RAAHVFFTDSCPDAL
K120 ALFNELVKSRAAKVI
K120 ALFNELVKSRAAKVI
S142 IAFLPYESQVYSLDS
Y145 LPYESQVYSLDSADS
S146 PYESQVYSLDSADSF
K184 ATLCATLKEYPAVRY
K196 VRYRGEYKDNALLAQ
K208 LAQLIQDKLDAYKAD
K225 TMGEGPDKARSQLLI
S269 DVYKYETSGIGEARV
K294 LWIALRHKHIAEVSQ
S306 VSQEVTRSLKDFSSS
K308 QEVTRSLKDFSSSKR
S313 SLKDFSSSKRMNTGE
K321 KRMNTGEKTTMRDLS
K321 KRMNTGEKTTMRDLS
S345 QKELSKYSTHLHLAE
T346 KELSKYSTHLHLAED
K364 HYQGTVDKLCRVEQD
K382 GTDAEGEKIKDPMRA
Y411 KIRIILLYIFLKNGI
S454 GVPIVTDSTLRRRSK
T455 VPIVTDSTLRRRSKP
Y473 ERISEQTYQLSRWTP
T479 TYQLSRWTPIIKDIM
K483 SRWTPIIKDIMEDTI
T489 IKDIMEDTIEDKLDT
K493 MEDTIEDKLDTKHYP
K497 IEDKLDTKHYPYIST
K497 IEDKLDTKHYPYIST
Y501 LDTKHYPYISTRSSA
S507 PYISTRSSASFSTTA
S509 ISTRSSASFSTTAVS
S511 TRSSASFSTTAVSAR
T512 RSSASFSTTAVSARY
S516 SFSTTAVSARYGHWH
T574 IGSTHILTPTKFLMD
- gap
- gap
- gap
- gap
- gap
S590 RHPDFRESSRVSFED
S594 FRESSRVSFEDQAPT
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