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ANGPT4 (human)

Overview ANGPT4 Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis. Note: This description may include information from UniProtKB. Protein type: Secreted; Secreted, signal peptide Cellular Component: extracellular space; extracellular region Molecular Function: transmembrane receptor protein tyrosine kinase activator activity; receptor tyrosine kinase binding Biological Process: positive regulation of angiogenesis; negative regulation of angiogenesis; positive regulation of peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase activation (dimerization); endothelial cell proliferation; positive regulation of blood vessel endothelial cell migration; angiogenesis; negative regulation of blood vessel endothelial cell migration; blood coagulation; leukocyte migration; negative regulation of apoptosis Reference #:  Q9Y264 (UniProtKB) Alt. Names/Synonyms: AGP4; ANG-3; ANG-4; ANG3; ANG4; angiopoietin 4; Angiopoietin-3; Angiopoietin-4; ANGP4; ANGPT4; dJ824F16.2 (angiopoietin 4); MGC138181; MGC138183 Gene Symbols: ANGPT4 Molecular weight: 56,849 Da Basal Isoelectric point: 9.1  Predict pI for various phosphorylation states

Select Structure to View Below ANGPT4

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S72-p	SNTLQREsLANPLHL
0	1		T150-p	TAQIRKLtDMEAQLL
0	1		T226-p	KKAKLLNtLsRQSAA
0	1		S228-p	AKLLNtLsRQSAALT
0	1		S248-p	LRGVRHNssLLQDQQ
0	1		S249-p	RGVRHNssLLQDQQH
0	1		L250	GVRHNssLLQDQQHS

	mouse
L75	SNSLQRDLPASRLHL
T159	KAQTHKLTAVEAQVL
-	gap
-	gap
S257	LHALSSNSSsLQQQQ
S258	HALSSNSSsLQQQQQ
S259-p	ALSSNSSsLQQQQQQ

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