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Protein Page:
THAP11 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
THAP11 Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers. Belongs to the THAP11 family. Interacts (via coiled coil domain) with HCFC1. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: intercellular bridge; cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; DNA binding; zinc ion binding
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent
Reference #:  Q96EK4 (UniProtKB)
Alt. Names/Synonyms: CTG-B43a; CTG-B45d; HRIHFB2206; RONIN; THA11; THAP domain containing 11; THAP domain-containing protein 11; THAP11
Gene Symbols: THAP11
Molecular weight: 34,455 Da
Basal Isoelectric point: 9.18  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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THAP11

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T25-p DKALHFYtFPKDAEL
0 4 K38-ub ELRRLWLkNVSRAGV
0 1 T78-p TYTVRVPtIFPLrGV
0 1 R83-m1 VPtIFPLrGVNERKV
0 1 S281-p KMKEMKGsIRHLRLT
  mouse

 
T25 DKALHFYTFPKDAEL
K38-ub ELRRLWLkNVSRAGV
T78 TYTVRVPTIFPLRGV
R83 VPTIFPLRGVNERKV
S272 KMKEMKGSIRHLRLT
  rat

 
T25 DKALHFYTFPKDAEL
K38 ELRRLWLKNVSRAGV
T78 TYTVRVPTIFPLRGV
R83 VPTIFPLRGVNERKV
S275 KMKEMKGSIRHLRLT
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