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Protein Page:
NP (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
NP a metabolic enzyme with purine-nucleoside phosphorylase activity. Defects are the cause of nucleoside phosphorylase deficiency (NP deficiency), with severe T-cell immunodeficiency with neurologic disorder in children. Note: This description may include information from UniProtKB.
Protein type: Transferase; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine; EC 2.4.2.1
Cellular Component: cytoskeleton; cytoplasm; intracellular; cytosol
Molecular Function: purine binding; nucleoside binding; drug binding; phosphate binding; purine-nucleoside phosphorylase activity
Biological Process: response to drug; nucleobase, nucleoside and nucleotide metabolic process; nicotinamide riboside catabolic process; inosine catabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; purine nucleotide catabolic process; immune response; positive regulation of T cell proliferation; purine base metabolic process; positive regulation of alpha-beta T cell differentiation; purine salvage
Reference #:  P00491 (UniProtKB)
Alt. Names/Synonyms: FLJ94043; FLJ97288; FLJ97312; Inosine phosphorylase; MGC117396; MGC125915; MGC125916; NP; nucleoside phosphorylase; PNP; PNPH; PRO1837; PUNP; Purine nucleoside phosphorylase; purine-nucleoside:orthophosphate ribosyltransferase
Gene Symbols: PNP
Molecular weight: 32,118 Da
Basal Isoelectric point: 6.45  Predict pI for various phosphorylation states
Select Structure to View Below

NP

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K22-u EWLLSHTkHRPQVAI
0 1 K95-a YEGYPLWkVTFPVRV
0 66 K95-u YEGYPLWkVTFPVRV
0 4 T169-p MSDAYDRtMRQRALs
0 2 S176-p tMRQRALstWkQMGE
0 2 T177-p MRQRALstWkQMGEQ
0 1 K179-u QRALstWkQMGEQRE
0 2 K211-u AECRVLQkLGADAVG
0 17 Y249-p TNKVIMDyEsLEKAN
0 1 S251-p KVIMDyEsLEKANHE
0 1 K254 MDyEsLEKANHEEVL
0 2 K265-u EEVLAAGkQAAQKLE
0 2 S289 IPLPDKAS_______
  mouse

 
E22 KWLLQHTEYRPQVAV
K95 YEGYSLSKVTFPVRV
K95-u YEGYSLSkVTFPVRV
D169 MSDAYDRDMRQKAFT
T176 DMRQKAFTAWKQMGE
A177 MRQKAFTAWKQMGEQ
K179 QKAFTAWKQMGEQRK
K210-u VAESRLLkMLGADAV
Y249 TNKVVMDYENLEkAN
N251 KVVMDYENLEkANHM
K254-u MDYENLEkANHMEVL
K265-u MEVLDAGkAAAQTLE
S289-p IPLPDRGs_______
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